SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4r8x URICASE
(Bacillus
fastidiosus) 		4 / 7 LEU A 106
TYR A 103
HIS A 105
TYR A   7
 None
 1.27A 1afsA-4r8xA:
undetectable		 1afsA-4r8xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4r8x URICASE
(Bacillus
fastidiosus) 		4 / 7 LEU A 106
TYR A 103
HIS A 105
TYR A   7
 None
 1.27A 1afsB-4r8xA:
undetectable		 1afsB-4r8xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4r8x URICASE
(Bacillus
fastidiosus) 		6 / 12 VAL A 265
LEU A 262
LYS A  26
ALA A 232
ILE A 231
ILE A  28
 None
 1.36A 1epbA-4r8xA:
undetectable		 1epbA-4r8xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 12 GLY A 268
ILE A 166
ALA A 232
ARG A 229
ILE A 244
 None
 1.09A 1ve3B-4r8xA:
undetectable		 1ve3B-4r8xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 4r8x URICASE
(Bacillus
fastidiosus) 		4 / 7 THR A 145
ASN A 266
TRP A 206
LEU A 262
 None
 1.07A 2hzqA-4r8xA:
undetectable		 2hzqA-4r8xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 12 ALA A 224
LEU A  22
GLU A 226
VAL A 144
TYR A 208
 None
 0.93A 3datA-4r8xA:
undetectable		 3datA-4r8xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 10 ALA A 224
LEU A  22
GLU A 226
VAL A 144
TYR A 208
 None
 0.78A 3fl9A-4r8xA:
undetectable		 3fl9A-4r8xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 12 ALA A 224
LEU A  22
GLU A 226
VAL A 144
TYR A 208
 None
 0.79A 3fl9B-4r8xA:
undetectable		 3fl9B-4r8xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 9 ALA A 224
LEU A  22
GLU A 226
VAL A 144
TYR A 208
 None
 0.82A 3fl9D-4r8xA:
undetectable		 3fl9D-4r8xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 12 ALA A 224
LEU A  22
GLU A 226
VAL A 144
TYR A 208
 None
 0.79A 3fl9G-4r8xA:
undetectable		 3fl9G-4r8xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 9 ALA A 224
LEU A  22
GLU A 226
VAL A 144
TYR A 208
 None
 0.92A 3jw3B-4r8xA:
undetectable		 3jw3B-4r8xA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_1
(16S RRNA METHYLASE)		 4r8x URICASE
(Bacillus
fastidiosus) 		4 / 4 ASN A 241
ASP A 195
GLU A 279
THR A 276
 None
 1.48A 3p2kD-4r8xA:
0.0		 3p2kD-4r8xA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4r8x URICASE
(Bacillus
fastidiosus) 		5 / 9 GLY A 205
TYR A 208
VAL A 265
GLU A 264
GLY A 165
 None
 1.26A 5zniA-4r8xA:
undetectable		 5zniA-4r8xA:
13.21