SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 221
HIS A 220
HIS A 281
HIS A 180
 NI  A 402 ( 2.7A)
NI  A 401 (-3.2A)
NI  A 402 (-3.2A)
NI  A 401 (-3.3A)
 0.81A 1ei6D-4r8zA:
undetectable		 1ei6D-4r8zA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 183
SER A 317
TYR A 187
 None
 0.87A 2q2hA-4r8zA:
undetectable
2q2hB-4r8zA:
undetectable		 2q2hA-4r8zA:
19.63
2q2hB-4r8zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 278
GLY A 223
GLY A 253
ASP A 171
GLY A 248
 None
None
None
NI  A 401 ( 4.5A)
None
 0.89A 2qe6A-4r8zA:
undetectable		 2qe6A-4r8zA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 250
GLY A 253
ARG A 173
ILE A 222
 None
 1.13A 4ac9C-4r8zA:
undetectable		 4ac9C-4r8zA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 250
GLY A 253
ARG A 173
ILE A 222
 None
 1.14A 4acaC-4r8zA:
undetectable		 4acaC-4r8zA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 313
HIS A 249
HIS A 282
HIS A 220
HIS A 180
 None
NI  A 402 (-3.2A)
NI  A 402 (-3.2A)
NI  A 401 (-3.2A)
NI  A 401 (-3.3A)
 1.46A 4bz6A-4r8zA:
undetectable
4bz6B-4r8zA:
undetectable		 4bz6A-4r8zA:
20.22
4bz6B-4r8zA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 304
GLU A 204
ARG A 345
 None
 0.87A 4mwvA-4r8zA:
undetectable		 4mwvA-4r8zA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 310
GLU A 185
VAL A 360
ALA A 361
 NI  A 401 ( 4.5A)
None
CL  A 403 ( 4.1A)
None
 0.95A 4nkxA-4r8zA:
undetectable		 4nkxA-4r8zA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 333
ILE A 334
LEU A 315
GLU A 314
 None
 0.65A 4w5nA-4r8zA:
undetectable		 4w5nA-4r8zA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 282
HIS A 281
HIS A 249
 NI  A 402 (-3.2A)
NI  A 402 (-3.2A)
NI  A 402 (-3.2A)
 0.48A 5zrdA-4r8zA:
undetectable		 5zrdA-4r8zA:
18.54