SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		6 / 11 PHE H  29
ASN H  74
GLY H  55
THR H  58
ILE H  70
LEU H  79
 None
 1.44A 1z11A-4r90H:
undetectable		 1z11A-4r90H:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		4 / 6 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.53A 3huoA-4r90H:
undetectable		 3huoA-4r90H:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		3 / 3 ASP H  99
ASN H  35
SER H 103
 CA  H 301 (-3.7A)
CA  H 301 (-2.9A)
None
 0.91A 3lslA-4r90H:
undetectable
3lslD-4r90H:
undetectable		 3lslA-4r90H:
22.18
3lslD-4r90H:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		3 / 3 SER H 103
ASP H  99
ASN H  35
 None
CA  H 301 (-3.7A)
CA  H 301 (-2.9A)
 0.96A 3lslA-4r90H:
undetectable
3lslD-4r90H:
undetectable		 3lslA-4r90H:
22.18
3lslD-4r90H:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		3 / 3 THR H  80
SER H  21
ARG H  19
 None
 0.82A 3phnA-4r90H:
undetectable		 3phnA-4r90H:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		5 / 10 VAL H 172
VAL H 191
SER H 189
ASN H 206
ASN H 164
 None
 1.48A 4ldoA-4r90H:
undetectable		 4ldoA-4r90H:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		5 / 10 LEU H 179
LEU H 187
ILE H 119
THR H 160
HIS H 209
 None
 1.12A 4mk4A-4r90H:
undetectable		 4mk4A-4r90H:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		3 / 3 TYR H  60
GLY H  66
THR H  69
 None
 0.11A 6cjkB-4r90H:
19.4		 6cjkB-4r90H:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN
(Lama
glama) 		5 / 12 VAL H 172
VAL H 191
SER H 189
ASN H 206
ASN H 164
 None
 1.44A 6h7mB-4r90H:
undetectable		 6h7mB-4r90H:
17.87