SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET L
CHAIN
(Lama
glama) 		6 / 12 TYR A  42
GLN A  95
PHE A 104
VAL B  37
ALA B  97
TRP B 109
 None
 0.61A 1h8sA-4r96A:
21.2		 1h8sA-4r96A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
(Lama
glama) 		4 / 4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 0.99A 1lqtB-4r96B:
undetectable		 1lqtB-4r96B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
(Lama
glama) 		4 / 4 ALA B  40
ARG B  38
GLN B  43
GLU B  46
 None
 1.01A 1lquB-4r96B:
undetectable		 1lquB-4r96B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET L
CHAIN
(Lama
glama) 		4 / 5 LEU A 185
GLY A 134
PRO A 126
VAL A 138
 None
 0.88A 2aojA-4r96A:
undetectable		 2aojA-4r96A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
(Lama
glama) 		4 / 6 LEU B 195
GLY B 196
ALA B 131
PRO B 132
 None
 0.43A 3huoA-4r96B:
undetectable		 3huoA-4r96B:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET L
CHAIN
(Lama
glama) 		4 / 6 LEU A 185
VAL A 138
PHE A 215
VAL A 156
 None
 1.14A 3soaA-4r96A:
undetectable		 3soaA-4r96A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
(Lama
glama) 		5 / 10 PHE B 128
GLY B 124
THR B 211
VAL B 204
VAL B 213
 None
 1.18A 4jx1B-4r96B:
undetectable		 4jx1B-4r96B:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
(Lama
glama) 		4 / 5 VAL B   2
TYR B  27
ARG B  98
TYR B 108
 None
 0.42A 4m7kH-4r96B:
27.8		 4m7kH-4r96B:
78.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET L
CHAIN
(Lama
glama) 		4 / 6 ASP A 176
THR A 178
TYR A 146
THR A 115
 None
 1.38A 5b6iB-4r96A:
undetectable		 5b6iB-4r96A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
(Lama
glama) 		3 / 3 TYR B  60
GLY B  66
THR B  69
 None
 0.19A 6cjkB-4r96B:
24.1		 6cjkB-4r96B:
53.81