SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 5 PHE A 246
TYR A 202
VAL A 295
VAL A 377
 None
BME  A 403 (-4.8A)
BME  A 403 ( 4.6A)
None
 1.41A 1dz6B-4r9iA:
undetectable		 1dz6B-4r9iA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 4r9i SERPIN-18
(Bombyx
mori) 		5 / 11 PRO A 384
LEU A 279
VAL A 243
GLY A 257
LEU A 283
 None
 1.30A 1fkpA-4r9iA:
undetectable		 1fkpA-4r9iA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4r9i SERPIN-18
(Bombyx
mori) 		5 / 9 ALA A 234
ILE A 282
VAL A 255
GLY A 257
ILE A 236
 None
 0.95A 1hshB-4r9iA:
undetectable		 1hshB-4r9iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4r9i SERPIN-18
(Bombyx
mori) 		5 / 11 PRO A 384
LEU A 279
VAL A 243
GLY A 257
LEU A 283
 None
 1.38A 1lwcA-4r9iA:
undetectable		 1lwcA-4r9iA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4r9i SERPIN-18
(Bombyx
mori) 		3 / 3 ASP A 306
LEU A 185
LEU A 343
 None
 0.79A 1np1B-4r9iA:
undetectable		 1np1B-4r9iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4r9i SERPIN-18
(Bombyx
mori) 		3 / 3 ASP A  33
ASP A 275
ASN A 382
 None
 0.78A 2bm9D-4r9iA:
undetectable		 2bm9D-4r9iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 4 ASP A 329
ASP A 326
ASP A 333
GLY A 337
 None
 1.41A 2igtC-4r9iA:
undetectable		 2igtC-4r9iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 5 LEU A 172
ASP A 306
ALA A 171
ILE A 184
 None
 1.12A 2qhfA-4r9iA:
undetectable		 2qhfA-4r9iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4r9i SERPIN-18
(Bombyx
mori) 		5 / 12 SER A 344
ALA A 187
LEU A  62
VAL A 311
ILE A 308
 None
 1.33A 3adsB-4r9iA:
undetectable		 3adsB-4r9iA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 7 GLU A 287
LEU A 239
LYS A 272
ASN A 238
 FLC  A 402 (-3.8A)
None
None
None
 1.26A 3k8mA-4r9iA:
undetectable		 3k8mA-4r9iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 7 GLU A 287
LEU A 239
LYS A 272
ASN A 238
 FLC  A 402 (-3.8A)
None
None
None
 1.31A 3k8mB-4r9iA:
undetectable		 3k8mB-4r9iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4r9i SERPIN-18
(Bombyx
mori) 		3 / 3 GLN A  98
THR A  21
ASN A  95
 None
 0.87A 3v4tE-4r9iA:
undetectable		 3v4tE-4r9iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 7 GLY A 141
ILE A 116
ASN A 105
GLN A 133
 None
 0.98A 4g0vA-4r9iA:
undetectable		 4g0vA-4r9iA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 6 LEU A  66
LEU A  69
SER A  73
THR A  77
 None
 0.98A 4ikiB-4r9iA:
undetectable		 4ikiB-4r9iA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 6 LEU A  85
THR A  77
LEU A  87
SER A  89
 None
 1.03A 4pwjA-4r9iA:
undetectable		 4pwjA-4r9iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4r9i SERPIN-18
(Bombyx
mori) 		4 / 5 LEU A 378
ASP A 379
LEU A 283
THR A  36
 None
 1.25A 4wozF-4r9iA:
undetectable
4wozH-4r9iA:
undetectable		 4wozF-4r9iA:
23.82
4wozH-4r9iA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4r9i SERPIN-18
(Bombyx
mori) 		5 / 12 ILE A 183
PHE A 131
LEU A  71
PHE A 139
ASN A  72
 None
 1.29A 5xxiA-4r9iA:
undetectable		 5xxiA-4r9iA:
21.36