SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 6 ARG G 123
GLY G 238
TYR G 242
TRP G 240
 None
 1.35A 1kf6M-4r9jG:
undetectable
1kf6N-4r9jG:
undetectable		 1kf6M-4r9jG:
16.07
1kf6N-4r9jG:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 6 LEU G 170
VAL G 171
TRP G 268
TYR G 182
 None
 0.88A 1s9qA-4r9jG:
undetectable		 1s9qA-4r9jG:
21.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0H_B_ACHB1289_0
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.25A 2j0hB-4r9jG:
41.4		 2j0hB-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0H_C_ACHC1289_0
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.31A 2j0hC-4r9jG:
40.5		 2j0hC-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0H_E_ACHE1289_0
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.47A 2j0hE-4r9jG:
41.4		 2j0hE-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J0H_F_ACHF1289_0
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.32A 2j0hF-4r9jG:
40.3		 2j0hF-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		8 / 10 SER G  91
LEU G 107
ASP G 109
ASP G 111
THR G 112
ARG G 122
GLU G 282
LYS G 284
 None
 0.29A 2j1gE-4r9jG:
41.7
2j1gF-4r9jG:
41.3		 2j1gE-4r9jG:
99.08
2j1gF-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 5 ASP G 125
SER G 127
LEU G 145
GLY G 146
 None
 0.45A 2j2pA-4r9jG:
39.9
2j2pB-4r9jG:
41.0		 2j2pA-4r9jG:
99.08
2j2pB-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1289_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.24A 2j2pB-4r9jG:
41.0		 2j2pB-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		6 / 8 SER G  91
LEU G 107
ASP G 109
ASP G 111
ARG G 122
GLU G 282
 None
 0.29A 2j2pA-4r9jG:
39.9
2j2pB-4r9jG:
41.0		 2j2pA-4r9jG:
99.08
2j2pB-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		5 / 9 SER G  91
LEU G 107
ASP G 109
ASP G 111
GLU G 282
 None
 0.32A 2j2pB-4r9jG:
41.0
2j2pC-4r9jG:
40.2		 2j2pB-4r9jG:
99.08
2j2pC-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		5 / 6 ASP G 125
SER G 127
SER G 143
LEU G 145
GLY G 146
 None
 0.41A 2j2pA-4r9jG:
39.9
2j2pC-4r9jG:
40.2		 2j2pA-4r9jG:
99.08
2j2pC-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_C_SC2C1290_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.32A 2j2pC-4r9jG:
40.2		 2j2pC-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		5 / 6 ASP G 129
ARG G 132
ASP G 133
THR G 136
LYS G 221
 None
SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.25A 2j2pE-4r9jG:
41.1
2j2pF-4r9jG:
40.0		 2j2pE-4r9jG:
99.08
2j2pF-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		5 / 9 SER G  91
LEU G 107
ASP G 109
ARG G 122
GLU G 282
 None
 0.23A 2j2pD-4r9jG:
40.1
2j2pE-4r9jG:
41.1		 2j2pD-4r9jG:
99.08
2j2pE-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		5 / 6 ASP G 125
SER G 127
SER G 143
LEU G 145
GLY G 146
 None
 0.37A 2j2pD-4r9jG:
40.1
2j2pF-4r9jG:
40.0		 2j2pD-4r9jG:
99.08
2j2pF-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1290_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
ASP G 133
THR G 136
LYS G 221
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
 0.30A 2j2pF-4r9jG:
40.0		 2j2pF-4r9jG:
99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 6 SER G  91
ASP G 109
ASP G 111
GLU G 282
 None
 0.39A 2j2pE-4r9jG:
41.1
2j2pF-4r9jG:
40.0		 2j2pE-4r9jG:
99.08
2j2pF-4r9jG:
99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 7 PHE G 130
GLY G 252
GLY G 126
PHE G 218
 None
 0.91A 3ko0M-4r9jG:
undetectable
3ko0P-4r9jG:
undetectable		 3ko0M-4r9jG:
16.59
3ko0P-4r9jG:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4r9j FICOLIN-2
(Homo
sapiens) 		3 / 3 ASP G 208
TRP G 117
SER G 248
 ACT  G 304 (-3.8A)
None
None
 1.05A 4lrhA-4r9jG:
undetectable		 4lrhA-4r9jG:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4r9j FICOLIN-2
(Homo
sapiens) 		5 / 12 GLY G 126
GLU G 147
ASN G 264
SER G 277
ILE G 266
 None
 1.22A 4pb1A-4r9jG:
undetectable		 4pb1A-4r9jG:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA304_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4r9j FICOLIN-2
(Homo
sapiens) 		4 / 4 ARG G 132
THR G 136
GLY G 142
PHE G 141
 SO4  G 305 (-4.8A)
SO4  G 305 (-3.5A)
None
None
 1.33A 5uunA-4r9jG:
0.0		 5uunA-4r9jG:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 4r9j FICOLIN-2
(Homo
sapiens) 		5 / 12 TRP G 241
PHE G 185
VAL G 168
SER G 281
TYR G 137
 None
 1.42A 6cm4A-4r9jG:
undetectable		 6cm4A-4r9jG:
19.67