SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r9m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE
(Escherichia
coli) 		4 / 7 GLU A  85
GLU A  76
GLU A  57
GLU A  73
 None
MG  A 201 (-2.9A)
None
None
 1.21A 1knyA-4r9mA:
undetectable
1knyB-4r9mA:
undetectable		 1knyA-4r9mA:
20.00
1knyB-4r9mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE
(Escherichia
coli) 		4 / 7 ASP A  16
LEU A  12
GLN A  22
ARG A  10
 None
 1.05A 2qqcG-4r9mA:
undetectable
2qqcJ-4r9mA:
undetectable		 2qqcG-4r9mA:
13.94
2qqcJ-4r9mA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE
(Escherichia
coli) 		4 / 5 ARG A  10
ASP A  16
GLU A  63
LYS A  68
 None
 1.44A 2xrzA-4r9mA:
undetectable
2xrzB-4r9mA:
undetectable		 2xrzA-4r9mA:
18.76
2xrzB-4r9mA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE
(Escherichia
coli) 		5 / 12 PHE A  86
GLY A 111
ILE A 164
ASP A 109
THR A 113
 None
 1.37A 3a25A-4r9mA:
undetectable		 3a25A-4r9mA:
25.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE
(Escherichia
coli) 		5 / 8 GLU A  76
GLU A  85
GLN A  87
ILE A  88
LEU A 122
 MG  A 201 (-2.9A)
None
None
None
None
 0.88A 4mj8A-4r9mA:
23.0		 4mj8A-4r9mA:
54.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE
(Escherichia
coli) 		4 / 6 VAL A  62
LYS A  68
ILE A  90
TYR A  19
 None
 1.21A 5q1sA-4r9mA:
undetectable		 5q1sA-4r9mA:
20.90