SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		6 / 12 ILE A 260
MET A 124
VAL A  81
LEU A 126
ILE A   7
ILE A 204
 None
 1.28A 1epbA-4r9oA:
undetectable		 1epbA-4r9oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		4 / 7 TYR A  21
MET A  19
ASP A  50
HIS A 128
 None
 1.21A 1t03A-4r9oA:
undetectable		 1t03A-4r9oA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		3 / 3 MET A 134
ASN A 179
GLN A 198
 None
 0.86A 1xoqB-4r9oA:
undetectable		 1xoqB-4r9oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		4 / 7 ALA A  52
TYR A  55
MET A 207
HIS A 128
 None
 1.04A 2pncA-4r9oA:
undetectable		 2pncA-4r9oA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A 217
PHE A 218
LEU A 230
ARG A 268
LEU A 280
 None
 1.37A 2qd4B-4r9oA:
undetectable		 2qd4B-4r9oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 11 ALA A  71
LEU A  42
ILE A  38
ILE A  80
PHE A  64
 None
 1.01A 2w9sB-4r9oA:
undetectable		 2w9sB-4r9oA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 10 VAL A  49
ILE A  80
LEU A 117
GLY A  65
ALA A  63
 None
 1.09A 2xf3A-4r9oA:
undetectable		 2xf3A-4r9oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A  24
ARG A  23
GLU A  66
ALA A  63
PHE A  37
 None
 1.18A 3axtA-4r9oA:
undetectable		 3axtA-4r9oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A  24
ILE A 260
GLU A  66
ALA A  63
PHE A  37
 None
 1.10A 3axtA-4r9oA:
undetectable		 3axtA-4r9oA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 TRP A 209
GLN A 180
THR A  82
VAL A  81
ILE A  86
 None
 1.24A 3elzA-4r9oA:
undetectable		 3elzA-4r9oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 11 TRP A 209
GLN A 180
THR A  82
VAL A  81
ILE A  86
 None
 1.26A 3elzB-4r9oA:
undetectable		 3elzB-4r9oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 TRP A 209
GLN A 180
THR A  82
VAL A  81
ILE A  86
 None
 1.18A 3em0A-4r9oA:
undetectable		 3em0A-4r9oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		3 / 3 GLU A  39
LEU A  42
ASP A  43
 None
 0.28A 3ko0A-4r9oA:
undetectable		 3ko0A-4r9oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		3 / 3 GLU A  39
LEU A  42
ASP A  43
 None
 0.21A 3ko0T-4r9oA:
undetectable		 3ko0T-4r9oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		4 / 6 ILE A 266
VAL A 269
ARG A 270
LEU A 273
 None
 0.85A 3kp6A-4r9oA:
undetectable
3kp6B-4r9oA:
2.7		 3kp6A-4r9oA:
21.16
3kp6B-4r9oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		3 / 3 GLN A 198
THR A 195
LEU A 126
 None
 0.62A 3ondB-4r9oA:
undetectable		 3ondB-4r9oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		3 / 3 GLU A 141
ASP A 137
ASP A 102
 None
 0.67A 4gc9A-4r9oA:
undetectable		 4gc9A-4r9oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 ILE A  80
ALA A 110
SER A 113
LEU A 114
LEU A 117
 None
 0.86A 4m11B-4r9oA:
undetectable		 4m11B-4r9oA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		4 / 6 MET A 124
ILE A   7
ARG A 205
VAL A 181
 None
 1.41A 4mk4B-4r9oA:
undetectable		 4mk4B-4r9oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 LEU A 273
LEU A  42
LEU A  74
ALA A  67
PHE A  64
 None
 1.15A 4rtbA-4r9oA:
8.3		 4rtbA-4r9oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 GLU A 267
LEU A  42
LEU A  74
ARG A  75
ALA A  67
 None
 1.23A 4wcxC-4r9oA:
6.2		 4wcxC-4r9oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 GLY A 264
LEU A  42
LEU A  74
ARG A  75
ALA A  67
 None
 1.07A 4wcxC-4r9oA:
6.2		 4wcxC-4r9oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		4 / 8 PHE A  64
ALA A  71
LEU A  68
GLY A  65
 None
 0.79A 4xk8a-4r9oA:
undetectable		 4xk8a-4r9oA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		4 / 4 LEU A  34
LEU A  68
GLY A  65
GLU A  66
 None
 0.91A 5hhjA-4r9oA:
undetectable		 5hhjA-4r9oA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 11 ARG A   4
PHE A  14
VAL A  81
ILE A  80
LEU A  42
 None
 1.43A 5huaA-4r9oA:
undetectable		 5huaA-4r9oA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		4 / 5 LEU A 176
PHE A 155
LEU A 168
PHE A 160
 None
 1.24A 5xdxC-4r9oA:
undetectable
5xdxJ-4r9oA:
undetectable		 5xdxC-4r9oA:
22.70
5xdxJ-4r9oA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 4r9o PUTATIVE ALDO/KETO
REDUCTASE
(Salmonella
enterica) 		5 / 12 ILE A 250
LEU A 217
VAL A 186
LEU A 253
LEU A 196
 None
 1.26A 6b54A-4r9oA:
undetectable		 6b54A-4r9oA:
22.09