SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4r9p RE28239P
(Drosophila
melanogaster) 		5 / 10 PHE A  98
VAL A  62
VAL A  60
ILE A  56
LEU A  79
 None
 1.24A 1fe2A-4r9pA:
undetectable		 1fe2A-4r9pA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4r9p RE28239P
(Drosophila
melanogaster) 		5 / 11 GLY A 117
ILE A  93
ALA A  72
VAL A 221
ILE A 223
 None
 1.10A 2nnhA-4r9pA:
undetectable		 2nnhA-4r9pA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4r9p RE28239P
(Drosophila
melanogaster) 		4 / 6 ILE A  81
ARG A  92
LEU A  95
LEU A  79
 None
 1.00A 2rlfA-4r9pA:
undetectable
2rlfD-4r9pA:
undetectable		 2rlfA-4r9pA:
11.16
2rlfD-4r9pA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4r9p RE28239P
(Drosophila
melanogaster) 		4 / 7 PHE A  98
ALA A  70
ALA A  72
LEU A  79
 None
 0.96A 2wx2A-4r9pA:
undetectable		 2wx2A-4r9pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4r9p RE28239P
(Drosophila
melanogaster) 		5 / 9 ILE A 153
LEU A 232
VAL A 224
LEU A 202
ILE A  42
 None
 1.18A 4r38C-4r9pA:
undetectable		 4r38C-4r9pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4r9p RE28239P
(Drosophila
melanogaster) 		4 / 7 PHE A  88
ILE A  93
ASP A  85
GLY A  97
 None
 0.90A 5h3aA-4r9pA:
undetectable		 5h3aA-4r9pA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4r9p RE28239P
(Drosophila
melanogaster) 		4 / 6 VAL A 138
TYR A 133
VAL A 118
SER A 136
 None
 0.98A 5jwaH-4r9pA:
undetectable		 5jwaH-4r9pA:
19.19