SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4r9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 6 THR A  64
LEU A  93
GLY A  91
LYS A 103
 None
 1.27A 1gtiC-4r9xA:
undetectable		 1gtiC-4r9xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 6 ILE A   5
GLY A 199
ALA A 201
HIS A 197
 None
 0.88A 1wmqA-4r9xA:
undetectable		 1wmqA-4r9xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 6 ILE A   5
GLY A 199
ALA A 201
HIS A 197
 None
 0.87A 1wmqB-4r9xA:
undetectable		 1wmqB-4r9xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 6 ILE A   5
GLY A 199
ALA A 201
HIS A 197
 None
 0.86A 1wpuA-4r9xA:
undetectable		 1wpuA-4r9xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 6 ILE A   5
GLY A 199
ALA A 201
HIS A 197
 None
 0.86A 1wpuB-4r9xA:
undetectable		 1wpuB-4r9xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 6 ILE A   5
GLY A 199
ALA A 201
HIS A 197
 None
 0.84A 1wrqA-4r9xA:
undetectable		 1wrqA-4r9xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 6 ILE A   5
GLY A 199
ALA A 201
HIS A 197
 None
 0.85A 1wrqB-4r9xA:
undetectable		 1wrqB-4r9xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		3 / 3 ASP A 123
GLU A   3
TYR A  29
 None
 0.76A 1wsvA-4r9xA:
undetectable		 1wsvA-4r9xA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 12 PRO A 128
ILE A 122
VAL A 144
ILE A 166
LEU A 173
 None
 1.22A 1z9hD-4r9xA:
undetectable		 1z9hD-4r9xA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 10 ILE A  50
ALA A  47
LEU A   9
LEU A  25
ILE A  23
 None
 1.19A 2w9sD-4r9xA:
undetectable		 2w9sD-4r9xA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 10 ILE A  50
ALA A  47
LEU A   9
LEU A  25
ILE A  23
 None
 1.18A 2w9sF-4r9xA:
undetectable		 2w9sF-4r9xA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 12 ILE A   5
VAL A 174
LEU A 145
GLU A  24
TYR A  29
 None
 1.38A 2ziaB-4r9xA:
undetectable		 2ziaB-4r9xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		3 / 3 HIS A 119
GLU A  24
HIS A 197
 PGE  A 301 (-3.3A)
None
None
 0.90A 3ba0A-4r9xA:
undetectable		 3ba0A-4r9xA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 5 PRO A 158
THR A 180
VAL A 179
GLY A 178
 None
 1.16A 3elzA-4r9xA:
undetectable		 3elzA-4r9xA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 11 GLN A 172
MET A 132
LEU A 160
GLN A 164
THR A 191
 None
 1.50A 3elzB-4r9xA:
undetectable		 3elzB-4r9xA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		3 / 3 ASP A 106
LEU A 107
GLN A  81
 CA  A 303 (-2.9A)
None
None
 0.81A 3g4lA-4r9xA:
undetectable		 3g4lA-4r9xA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 8 VAL A 116
ILE A 125
VAL A  99
GLY A  91
 None
 0.84A 3hjoB-4r9xA:
undetectable		 3hjoB-4r9xA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 9 LEU A  93
PHE A  63
THR A 134
LEU A 173
GLY A  91
 None
PGE  A 301 (-4.3A)
None
None
None
 1.23A 3nxuB-4r9xA:
undetectable		 3nxuB-4r9xA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 7 VAL A  54
VAL A  89
LEU A  90
VAL A 141
 None
 1.09A 4e1gB-4r9xA:
undetectable		 4e1gB-4r9xA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 12 GLY A  32
GLY A  33
MET A  55
ILE A   5
PHE A  63
 PGE  A 301 (-3.6A)
None
PGE  A 301 ( 4.4A)
None
PGE  A 301 (-4.3A)
 1.15A 4fglA-4r9xA:
undetectable
4fglB-4r9xA:
undetectable		 4fglA-4r9xA:
21.51
4fglB-4r9xA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 11 ILE A  23
ILE A 212
ILE A  50
ALA A  18
VAL A  48
 None
 1.00A 4h1nA-4r9xA:
undetectable		 4h1nA-4r9xA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		5 / 11 PHE A  63
GLY A  32
GLY A  33
MET A  55
ILE A   5
 PGE  A 301 (-4.3A)
PGE  A 301 (-3.6A)
None
PGE  A 301 ( 4.4A)
None
 1.23A 4zvmA-4r9xA:
undetectable
4zvmB-4r9xA:
undetectable		 4zvmA-4r9xA:
21.20
4zvmB-4r9xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		3 / 3 VAL A 179
GLU A  24
GLU A   3
 None
 0.95A 5jsdB-4r9xA:
undetectable
5jsdC-4r9xA:
undetectable		 5jsdB-4r9xA:
15.19
5jsdC-4r9xA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4r9x COPPER HOMEOSTASIS
PROTEIN CUTC
(Bacillus
anthracis) 		4 / 8 ALA A  44
VAL A  48
ILE A 212
VAL A   4
 None
 0.86A 5nujA-4r9xA:
undetectable		 5nujA-4r9xA:
15.38