SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ra6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.97A 1hrkA-4ra6B:
3.1		 1hrkA-4ra6B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.97A 1hrkB-4ra6B:
3.1		 1hrkB-4ra6B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 SER A 118
GLY A  10
ASP A  84
LYS A 154
ILE A  12
 None
 1.27A 1lhuA-4ra6A:
undetectable		 1lhuA-4ra6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.89A 2pxcA-4ra6B:
undetectable		 2pxcA-4ra6B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		6 / 12 LEU B 324
ILE B 302
MET B 290
VAL B 228
VAL B 202
PRO B 256
 None
 1.33A 2ygpA-4ra6B:
undetectable		 2ygpA-4ra6B:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 9 THR A  80
VAL A 140
SER A 165
ILE A  12
GLY A  82
 None
 1.16A 3cv9A-4ra6A:
undetectable		 3cv9A-4ra6A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.81A 3elwA-4ra6B:
undetectable		 3elwA-4ra6B:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 6 GLY A  10
THR A 107
GLU A  22
GLU A  29
 None
None
None
GOL  A 201 (-3.5A)
 1.04A 3fpjA-4ra6A:
undetectable		 3fpjA-4ra6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.89A 3p97A-4ra6B:
undetectable		 3p97A-4ra6B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.89A 3p97C-4ra6B:
undetectable		 3p97C-4ra6B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.88A 4ctjC-4ra6B:
undetectable		 4ctjC-4ra6B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.87A 4ctkA-4ra6B:
undetectable		 4ctkA-4ra6B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.85A 4ctkC-4ra6B:
undetectable		 4ctkC-4ra6B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 10 PHE B 216
GLY B 231
VAL B 204
ILE B 227
VAL B 228
 None
 1.16A 4jx1B-4ra6B:
undetectable		 4jx1B-4ra6B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.87A 5e9qC-4ra6B:
undetectable		 5e9qC-4ra6B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.88A 5ehgA-4ra6B:
undetectable		 5ehgA-4ra6B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.90A 5ehgC-4ra6B:
undetectable		 5ehgC-4ra6B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.90A 5eifA-4ra6B:
undetectable		 5eifA-4ra6B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.86A 5eifC-4ra6B:
undetectable		 5eifC-4ra6B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 8 HIS A  81
LEU A  63
TRP A  60
THR B 297
 None
 1.17A 5hs6A-4ra6A:
2.4		 5hs6A-4ra6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.93A 5ikmA-4ra6B:
undetectable		 5ikmA-4ra6B:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 148
GLU A 164
LYS A 145
VAL A 146
 None
 0.80A 5jh7C-4ra6A:
undetectable		 5jh7C-4ra6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.85A 5kqrA-4ra6B:
undetectable		 5kqrA-4ra6B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.88A 5kqsA-4ra6B:
undetectable		 5kqsA-4ra6B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 ILE B 229
PRO B 238
LEU B 244
GLY B 235
GLY B 231
 None
 0.99A 5l6eA-4ra6B:
undetectable		 5l6eA-4ra6B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.87A 5m5bA-4ra6B:
undetectable		 5m5bA-4ra6B:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.86A 5njvA-4ra6B:
undetectable		 5njvA-4ra6B:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.83A 5njvB-4ra6B:
undetectable		 5njvB-4ra6B:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.92A 5njvC-4ra6B:
undetectable		 5njvC-4ra6B:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.90A 5vimA-4ra6B:
undetectable		 5vimA-4ra6B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.89A 5vimB-4ra6B:
undetectable		 5vimB-4ra6B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.83A 5wz1B-4ra6B:
undetectable		 5wz1B-4ra6B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.89A 5wz2A-4ra6B:
undetectable		 5wz2A-4ra6B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.88A 5wz2B-4ra6B:
undetectable		 5wz2B-4ra6B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 GLY B 288
GLY B 231
GLY B 235
GLY B 267
ILE B 229
 None
 0.90A 5wz2C-4ra6B:
undetectable		 5wz2C-4ra6B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 162
SER A 109
ILE A  78
THR A  80
ILE A 128
 None
 1.23A 5y80A-4ra6A:
undetectable		 5y80A-4ra6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4ra6 L-ASPARAGINASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
PHE A 163
HIS A  81
THR A  85
LEU A  25
 None
 1.39A 6djzB-4ra6A:
undetectable		 6djzB-4ra6A:
21.16