SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4raa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 6 ASP A 126
GLU A 145
ARG A 146
LYS A 131
 None
None
PO4  A 400 (-3.7A)
None
 1.37A 1yc2A-4raaA:
undetectable
1yc2B-4raaA:
undetectable
1yc2E-4raaA:
undetectable		 1yc2A-4raaA:
18.90
1yc2B-4raaA:
18.90
1yc2E-4raaA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 4 LEU A 110
ILE A  97
ILE A 122
ALA A 123
 None
 0.83A 2i30A-4raaA:
undetectable		 2i30A-4raaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ARG A 146
SER A 185
TYR A 144
 PO4  A 400 (-3.7A)
None
None
 0.98A 2q2hA-4raaA:
undetectable
2q2hB-4raaA:
undetectable		 2q2hA-4raaA:
15.57
2q2hB-4raaA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		5 / 12 PHE A 241
VAL A 289
ALA A 238
PHE A 218
TYR A 211
 None
 1.30A 3apxA-4raaA:
undetectable		 3apxA-4raaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		5 / 11 HIS A 239
ILE A 227
ILE A 235
PHE A 218
VAL A 230
 None
 1.31A 3rf4B-4raaA:
undetectable
3rf4C-4raaA:
undetectable		 3rf4B-4raaA:
15.15
3rf4C-4raaA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		5 / 11 PRO A 249
THR A 204
GLY A 205
PRO A 206
PRO A 222
 None
 1.24A 3t8nD-4raaA:
undetectable
3t8nF-4raaA:
0.7		 3t8nD-4raaA:
15.43
3t8nF-4raaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		5 / 11 THR A 204
GLY A 205
PRO A 206
PRO A 222
PRO A 249
 None
 1.24A 3t8nD-4raaA:
undetectable
3t8nF-4raaA:
0.7		 3t8nD-4raaA:
15.43
3t8nF-4raaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASP A 177
THR A 221
PRO A 222
 None
 0.62A 3tkgD-4raaA:
undetectable		 3tkgD-4raaA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 8 VAL A 182
LEU A 164
LEU A 158
ILE A 235
 None
 0.86A 3u5kA-4raaA:
undetectable		 3u5kA-4raaA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 8 VAL A 182
LEU A 164
LEU A 158
ILE A 235
 None
 0.89A 3u5kC-4raaA:
undetectable		 3u5kC-4raaA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		3 / 3 THR A 215
ASN A 216
GLU A 159
 None
 0.64A 3v4tA-4raaA:
undetectable
3v4tC-4raaA:
undetectable		 3v4tA-4raaA:
21.98
3v4tC-4raaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 5 VAL A 182
LEU A 164
LEU A 158
ILE A 235
 None
 0.90A 4a9jC-4raaA:
undetectable		 4a9jC-4raaA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		3 / 3 GLU A 145
ILE A 108
ALA A 124
 None
 0.51A 4wnwB-4raaA:
undetectable		 4wnwB-4raaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 8 PHE A 253
PRO A 249
LEU A 251
LEU A 254
 None
 1.13A 5dzkF-4raaA:
undetectable
5dzkT-4raaA:
undetectable		 5dzkF-4raaA:
22.79
5dzkT-4raaA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 5 PHE A  34
GLY A 300
ILE A  32
LEU A 301
 None
 0.85A 5dzkB-4raaA:
undetectable
5dzkI-4raaA:
undetectable
5dzkW-4raaA:
undetectable		 5dzkB-4raaA:
22.79
5dzkI-4raaA:
19.55
5dzkW-4raaA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 5 PHE A  34
GLY A 300
ILE A  32
LEU A 301
 None
 0.85A 5dzkd-4raaA:
undetectable
5dzkk-4raaA:
undetectable
5dzky-4raaA:
undetectable		 5dzkd-4raaA:
22.79
5dzkk-4raaA:
19.55
5dzky-4raaA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4raa PUTATIVE EXPORTED
PROTEIN
(Bacteroides
fragilis) 		4 / 6 PHE A 113
ARG A  68
GLU A 281
VAL A 339
 None
 1.31A 5h4dA-4raaA:
undetectable		 5h4dA-4raaA:
24.19