SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 122
PHE A 170
ASP A 201
TYR A 127
 None
 0.89A 2aouA-4raeA:
4.9		 2aouA-4raeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 122
PHE A 170
ASP A 201
TYR A 127
 None
 0.86A 2aouB-4raeA:
undetectable		 2aouB-4raeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 336
ARG A 292
THR A 296
LEU A 299
 None
 0.95A 2einN-4raeA:
undetectable
2einW-4raeA:
undetectable		 2einN-4raeA:
20.89
2einW-4raeA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 198
ILE A 171
VAL A 161
ALA A 160
ILE A 142
 None
 1.13A 2h42B-4raeA:
undetectable		 2h42B-4raeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 176
GLY A 179
GLN A 180
VAL A 182
ARG A 146
 None
 1.35A 2q7lA-4raeA:
undetectable		 2q7lA-4raeA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 359
GLU A 353
LEU A 351
TYR A 329
 None
 1.21A 2w8yA-4raeA:
undetectable		 2w8yA-4raeA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 365
PHE A 358
VAL A 306
LEU A 299
 None
 0.87A 2w98B-4raeA:
2.6		 2w98B-4raeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A 278
TYR A  82
PHE A 234
VAL A 285
 None
 1.48A 2x7hA-4raeA:
2.4		 2x7hA-4raeA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A 278
TYR A  82
PHE A 234
VAL A 285
 None
 1.46A 2x7hB-4raeA:
4.2		 2x7hB-4raeA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 297
PHE A 316
ASN A 355
ARG A 294
LEU A  36
 None
 1.27A 3aobC-4raeA:
2.0		 3aobC-4raeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 174
SER A 309
ASN A 176
 None
 0.66A 3lslG-4raeA:
undetectable		 3lslG-4raeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 171
ALA A 144
ILE A 121
VAL A 161
VAL A 169
 None
 1.09A 3me6A-4raeA:
undetectable		 3me6A-4raeA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 ASN A 175
ALA A 172
TYR A 204
ALA A 311
 None
 1.15A 3twpD-4raeA:
undetectable		 3twpD-4raeA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 365
LEU A 345
GLY A 343
ASP A 368
VAL A 370
 None
 0.80A 4c9lA-4raeA:
undetectable		 4c9lA-4raeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 365
LEU A 345
GLY A 343
ASP A 368
VAL A 370
 None
 0.86A 4c9lB-4raeA:
undetectable		 4c9lB-4raeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 365
LEU A 345
GLY A 343
ASP A 368
VAL A 370
 None
 0.78A 4c9oA-4raeA:
undetectable		 4c9oA-4raeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 365
LEU A 345
GLY A 343
ASP A 368
VAL A 370
 None
 0.78A 4c9oB-4raeA:
undetectable		 4c9oB-4raeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 PRO A 177
LEU A 315
ILE A 307
ARG A 305
 None
 1.10A 4f4dA-4raeA:
1.3		 4f4dA-4raeA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLW_A_TESA1001_1
(ANDROGEN RECEPTOR)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 176
GLY A 179
GLN A 180
VAL A 182
ARG A 146
 None
 1.37A 4hlwA-4raeA:
undetectable		 4hlwA-4raeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  96
ASN A  95
ILE A  89
VAL A 214
 None
 1.26A 4uy87-4raeA:
undetectable		 4uy87-4raeA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 267
ALA A 269
SER A 231
GLY A 239
ALA A 237
 None
 1.08A 5lf7H-4raeA:
undetectable
5lf7N-4raeA:
undetectable		 5lf7H-4raeA:
21.78
5lf7N-4raeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 108
ALA A 112
ILE A 133
ASP A 201
PHE A 170
 None
 1.33A 5vlmA-4raeA:
undetectable		 5vlmA-4raeA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 108
ALA A 112
ILE A 133
ASP A 201
PHE A 170
 None
 1.22A 5vlmG-4raeA:
undetectable		 5vlmG-4raeA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 228
MET A 230
THR A 229
LEU A 241
 None
 1.16A 5z86J-4raeA:
undetectable		 5z86J-4raeA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 306
VAL A 314
ASP A 368
PHE A 358
TYR A 329
 None
 1.49A 6mxtA-4raeA:
undetectable		 6mxtA-4raeA:
22.27