SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4raf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
 None
 1.10A 1s14A-4rafA:
undetectable		 1s14A-4rafA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
 None
 1.11A 1s14B-4rafA:
undetectable		 1s14B-4rafA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		4 / 6 TRP A  53
TYR A 140
GLY A  90
SER A  88
 None
 1.30A 2a3cA-4rafA:
undetectable		 2a3cA-4rafA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		4 / 6 TRP A  53
TYR A 140
GLY A  90
SER A  88
 None
 1.29A 2a3cB-4rafA:
undetectable		 2a3cB-4rafA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		4 / 6 PHE A 291
ILE A 134
VAL A 132
PHE A 141
 None
 0.92A 2cizA-4rafA:
undetectable		 2cizA-4rafA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		4 / 6 LEU A  46
LEU A 133
PRO A  92
VAL A  97
 None
 1.06A 2dqyC-4rafA:
undetectable		 2dqyC-4rafA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 1.01A 3g2oA-4rafA:
undetectable		 3g2oA-4rafA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 0.88A 3g2oB-4rafA:
undetectable		 3g2oB-4rafA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 GLU A  35
ASN A 283
ASP A  60
VAL A 193
PHE A   4
 None
None
MN  A 401 (-2.5A)
None
None
 1.29A 3k13A-4rafA:
undetectable		 3k13A-4rafA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
 None
 1.10A 3lpsA-4rafA:
undetectable		 3lpsA-4rafA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 11 SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
 None
 1.23A 4urnB-4rafA:
undetectable		 4urnB-4rafA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 PRO A 343
LEU A 345
VAL A 357
TYR A 311
LEU A 351
 None
 1.43A 5cyqA-4rafA:
undetectable		 5cyqA-4rafA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		4 / 6 ARG A  33
ASP A 239
GLY A 240
ASP A 243
 None
MN  A 401 (-2.6A)
MN  A 401 ( 4.8A)
None
 1.27A 5hp1A-4rafA:
undetectable		 5hp1A-4rafA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens) 		5 / 12 PRO A 343
LEU A 345
VAL A 357
TYR A 311
LEU A 351
 None
 1.44A 6eliA-4rafA:
0.9		 6eliA-4rafA:
12.11