SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4raj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A  90
ALA A 149
LEU A 184
SER A 180
 None
 1.16A 1tt6B-4rajA:
undetectable		 1tt6B-4rajA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A  21
ALA A 139
LEU A 208
SER A 209
 None
 1.34A 1tyrA-4rajA:
undetectable		 1tyrA-4rajA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A  90
ALA A 149
LEU A 184
SER A 180
 None
 1.14A 1tyrA-4rajA:
undetectable		 1tyrA-4rajA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		5 / 12 ILE A 162
PHE A 163
ASP A  99
GLY A 170
TYR A 103
 None
 1.22A 1zz1B-4rajA:
undetectable
1zz1C-4rajA:
undetectable		 1zz1B-4rajA:
23.97
1zz1C-4rajA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 GLY A 152
GLN A 144
PHE A  61
PHE A  96
 None
PG6  A 301 (-4.1A)
None
None
 0.95A 2qx6A-4rajA:
undetectable
2qx6B-4rajA:
undetectable		 2qx6A-4rajA:
22.43
2qx6B-4rajA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 HIS A 125
ASP A 205
HIS A 217
LEU A  17
 None
 1.05A 3ablA-4rajA:
1.4
3ablC-4rajA:
undetectable
3ablP-4rajA:
undetectable		 3ablA-4rajA:
18.59
3ablC-4rajA:
19.34
3ablP-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A  90
ALA A 149
LEU A 184
SER A 180
 None
 1.12A 4d7bB-4rajA:
undetectable		 4d7bB-4rajA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 GLN A 144
PHE A  61
PHE A  96
GLY A 152
 PG6  A 301 (-4.1A)
None
None
None
 0.90A 4fgjA-4rajA:
undetectable
4fgjB-4rajA:
undetectable		 4fgjA-4rajA:
22.22
4fgjB-4rajA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A  90
ALA A 149
LEU A 184
SER A 180
 None
 1.10A 5a6iA-4rajA:
undetectable		 5a6iA-4rajA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 LEU A  17
HIS A 125
ASP A 205
HIS A 217
 None
 1.03A 5iy5C-4rajA:
undetectable
5iy5N-4rajA:
undetectable
5iy5P-4rajA:
undetectable		 5iy5C-4rajA:
19.71
5iy5N-4rajA:
18.59
5iy5P-4rajA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 HIS A 125
ASP A 205
HIS A 217
LEU A  17
 None
 1.08A 5w97A-4rajA:
undetectable
5w97C-4rajA:
2.5
5w97c-4rajA:
2.5		 5w97A-4rajA:
18.59
5w97C-4rajA:
19.34
5w97c-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 7 LEU A  17
HIS A 125
ASP A 205
HIS A 217
 None
 1.04A 5w97C-4rajA:
2.5
5w97a-4rajA:
undetectable
5w97c-4rajA:
2.5		 5w97C-4rajA:
19.34
5w97a-4rajA:
18.59
5w97c-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 HIS A 125
ASP A 205
HIS A 217
LEU A  17
 None
 1.02A 5wauA-4rajA:
undetectable
5wauC-4rajA:
undetectable
5wauc-4rajA:
undetectable		 5wauA-4rajA:
18.59
5wauC-4rajA:
19.34
5wauc-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 7 LEU A  17
HIS A 125
ASP A 205
HIS A 217
 None
 1.00A 5wauC-4rajA:
undetectable
5waua-4rajA:
undetectable
5wauc-4rajA:
undetectable		 5wauC-4rajA:
19.34
5waua-4rajA:
18.59
5wauc-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 HIS A 125
ASP A 205
HIS A 217
LEU A  17
 None
 1.06A 5x19A-4rajA:
undetectable
5x19C-4rajA:
2.5
5x19P-4rajA:
undetectable		 5x19A-4rajA:
18.59
5x19C-4rajA:
19.34
5x19P-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 7 HIS A 125
ASP A 205
HIS A 217
LEU A  17
 None
 1.06A 5x1bA-4rajA:
undetectable
5x1bC-4rajA:
2.5
5x1bP-4rajA:
2.5		 5x1bA-4rajA:
18.59
5x1bC-4rajA:
19.34
5x1bP-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 7 HIS A 125
ASP A 205
HIS A 217
LEU A  17
 None
 1.07A 5x1fA-4rajA:
2.6
5x1fC-4rajA:
2.6
5x1fP-4rajA:
1.8		 5x1fA-4rajA:
18.59
5x1fC-4rajA:
19.34
5x1fP-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 LEU A  17
HIS A 125
ASP A 205
HIS A 217
 None
 1.06A 5xdxC-4rajA:
undetectable
5xdxN-4rajA:
undetectable
5xdxP-4rajA:
undetectable		 5xdxC-4rajA:
19.71
5xdxN-4rajA:
18.59
5xdxP-4rajA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		5 / 10 ALA A 172
LEU A  54
TYR A  50
ASP A  99
GLY A 152
 None
 1.16A 5zbdA-4rajA:
undetectable		 5zbdA-4rajA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		5 / 10 ALA A 172
LEU A  54
TYR A  50
ASP A  99
GLY A 152
 None
 1.13A 5zbdB-4rajA:
undetectable		 5zbdB-4rajA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 8 LEU A  17
HIS A 125
ASP A 205
HIS A 217
 None
 1.06A 6nknC-4rajA:
undetectable
6nknN-4rajA:
undetectable
6nknP-4rajA:
undetectable		 6nknC-4rajA:
19.34
6nknN-4rajA:
18.59
6nknP-4rajA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4raj HEME OXYGENASE
(Chlamydomonas
reinhardtii) 		4 / 7 HIS A 125
ASP A 205
HIS A 217
LEU A  17
 None
 1.09A 6nmfA-4rajA:
1.1
6nmfC-4rajA:
undetectable
6nmfP-4rajA:
undetectable		 6nmfA-4rajA:
18.59
6nmfC-4rajA:
19.34
6nmfP-4rajA:
19.34