SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		5 / 12 ASP A 276
ASP A 256
ILE A 221
ILE A 242
THR A 223
 None
 1.46A 1kijA-4rapA:
undetectable		 1kijA-4rapA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 7 LEU A 112
LEU A 111
ILE A 101
TYR A 145
 None
 1.13A 2hc4A-4rapA:
undetectable		 2hc4A-4rapA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 8 VAL A  99
ARG A  33
GLY A  31
ALA A  32
 None
 0.93A 2xfsA-4rapA:
undetectable		 2xfsA-4rapA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 8 VAL A  99
ARG A  33
GLY A  31
ALA A  32
 None
 0.93A 2xh9A-4rapA:
undetectable		 2xh9A-4rapA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		5 / 12 GLU A 326
PHE A 187
HIS A 188
ALA A 118
LEU A 141
 None
 1.21A 2xkwB-4rapA:
undetectable		 2xkwB-4rapA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 7 GLY A  20
ASP A  89
TYR A  26
ARG A  75
 None
 0.96A 3arrA-4rapA:
3.0		 3arrA-4rapA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 7 GLY A  20
ASP A  89
TYR A  26
ARG A  75
 None
 1.03A 3aruA-4rapA:
4.1		 3aruA-4rapA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		5 / 12 ILE A 317
GLY A 298
ILE A 221
ILE A 255
VAL A 379
 None
 1.02A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		5 / 12 PHE A 296
ILE A 297
GLY A 298
VAL A 315
ALA A 222
 None
 0.76A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		5 / 12 PHE A 296
ILE A 297
GLY A 298
VAL A 315
VAL A 241
 None
 1.02A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 6 VAL A 333
ILE A 383
ILE A 317
LEU A 316
 None
 0.81A 3hegA-4rapA:
undetectable		 3hegA-4rapA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 8 VAL A 197
ILE A 101
VAL A 167
GLY A 192
 None
 0.85A 3hjoB-4rapA:
undetectable		 3hjoB-4rapA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		5 / 8 PHE A 187
GLY A 186
PHE A 182
PHE A 350
PHE A 171
 None
 1.46A 3ko0O-4rapA:
undetectable
3ko0Q-4rapA:
undetectable		 3ko0O-4rapA:
14.36
3ko0Q-4rapA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		3 / 3 THR A 236
ASN A 234
GLU A 240
 None
 0.75A 3v4tA-4rapA:
undetectable
3v4tC-4rapA:
undetectable		 3v4tA-4rapA:
23.83
3v4tC-4rapA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVV_A_CPFA1081_1
(APOLIPOPROTEIN(A))		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		5 / 9 SER A  67
ASP A  47
ASP A  49
TYR A  70
PHE A  71
 None
 1.35A 4bvvA-4rapA:
undetectable		 4bvvA-4rapA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 5 GLU A 326
SER A 304
ARG A 332
SER A 301
 None
 1.45A 4k17B-4rapA:
undetectable		 4k17B-4rapA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 6 LEU A 248
LEU A 245
ASN A 380
ILE A 383
 None
 0.87A 4ww7A-4rapA:
undetectable		 4ww7A-4rapA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		4 / 5 ILE A 317
LEU A 386
HIS A 244
VAL A 241
 None
 1.18A 5jmnB-4rapA:
undetectable		 5jmnB-4rapA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4rap GLYCOSYLTRANSFERASE
TIBC
(Escherichia
coli) 		3 / 3 TYR A  26
ASP A  27
GLN A  18
 None
 0.94A 6g1pA-4rapA:
undetectable		 6g1pA-4rapA:
22.65