SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ras'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.47A 1d1vA-4rasA:
undetectable
1d1vB-4rasA:
undetectable		 1d1vA-4rasA:
20.63
1d1vB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_B_H4BB601_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.47A 1d1wA-4rasA:
undetectable
1d1wB-4rasA:
undetectable		 1d1wA-4rasA:
20.63
1d1wB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_B_H4BB2600_1
(NITRIC-OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.45A 1fopA-4rasA:
undetectable
1fopB-4rasA:
undetectable		 1fopA-4rasA:
20.63
1fopB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 10 GLY A 158
VAL A 160
LEU A  83
LEU A 117
ALA A 167
 None
 1.42A 1pbcA-4rasA:
undetectable		 1pbcA-4rasA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.50A 1q2oA-4rasA:
undetectable
1q2oB-4rasA:
0.7		 1q2oA-4rasA:
20.81
1q2oB-4rasA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 GLU A 679
ARG A 293
ASP A 298
THR A 663
 None
 1.08A 1rr8C-4rasA:
undetectable		 1rr8C-4rasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 1rs8A-4rasA:
undetectable
1rs8B-4rasA:
undetectable		 1rs8A-4rasA:
20.66
1rs8B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 1rs9A-4rasA:
0.6
1rs9B-4rasA:
undetectable		 1rs9A-4rasA:
20.66
1rs9B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 9 ALA A 120
LEU A 201
GLY A 204
PHE A 123
GLY A 124
 None
 1.31A 1ru9H-4rasA:
undetectable
1ru9L-4rasA:
undetectable		 1ru9H-4rasA:
16.29
1ru9L-4rasA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 10 ALA A 120
LEU A 201
GLY A 204
PHE A 123
GLY A 124
 None
 1.28A 1ruaH-4rasA:
undetectable
1ruaL-4rasA:
undetectable		 1ruaH-4rasA:
16.29
1ruaL-4rasA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		3 / 3 ASP A 505
GLU A 539
ARG A 278
 None
 0.76A 1wopA-4rasA:
undetectable		 1wopA-4rasA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 8 LEU A 363
GLY A 360
LEU A  46
PRO A 127
 None
 0.92A 1ya4A-4rasA:
0.0		 1ya4A-4rasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 LEU A 363
GLY A 360
LEU A  46
PRO A 127
 None
 0.90A 1ya4B-4rasA:
undetectable		 1ya4B-4rasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 11 GLN A  30
ALA A  32
ALA A 186
GLY A 187
ALA A 189
 None
 1.17A 2f16H-4rasA:
undetectable
2f16I-4rasA:
undetectable		 2f16H-4rasA:
15.67
2f16I-4rasA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 11 GLN A  30
ALA A  32
ALA A 186
GLY A 187
ALA A 189
 None
 1.17A 2f16V-4rasA:
undetectable
2f16W-4rasA:
undetectable		 2f16V-4rasA:
15.67
2f16W-4rasA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.09A 2h77A-4rasA:
undetectable		 2h77A-4rasA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.08A 2h79A-4rasA:
undetectable		 2h79A-4rasA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 2hx2A-4rasA:
undetectable
2hx2B-4rasA:
undetectable		 2hx2A-4rasA:
20.66
2hx2B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 2nseA-4rasA:
undetectable
2nseB-4rasA:
undetectable		 2nseA-4rasA:
20.63
2nseB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 GLN A 122
ALA A 120
TYR A  88
GLY A  14
LEU A  13
 None
 1.28A 2nv4A-4rasA:
undetectable		 2nv4A-4rasA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ILE A 432
ARG A 428
PRO A 127
GLY A 124
 None
 0.75A 2pnjB-4rasA:
undetectable		 2pnjB-4rasA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 HIS A 450
ARG A 448
GLU A 456
TYR A 379
 None
None
None
B12  A 803 (-4.3A)
 1.34A 2q6uA-4rasA:
undetectable		 2q6uA-4rasA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		3 / 3 ARG A 287
GLN A 658
PRO A 659
 None
 0.85A 2qhfA-4rasA:
undetectable		 2qhfA-4rasA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		3 / 3 ARG A   9
ARG A   2
PRO A  15
 None
 1.13A 2wljA-4rasA:
0.7		 2wljA-4rasA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 1.11A 3ablP-4rasA:
undetectable
3ablW-4rasA:
undetectable		 3ablP-4rasA:
15.49
3ablW-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 MET A 263
ALA A 582
PHE A 367
GLY A 507
LEU A 479
 None
 1.22A 3aodC-4rasA:
3.6		 3aodC-4rasA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 10 LEU A 359
GLY A 364
ALA A 365
ASP A 366
GLY A 429
 None
 0.88A 3ekvA-4rasA:
undetectable		 3ekvA-4rasA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.09A 3gwsX-4rasA:
undetectable		 3gwsX-4rasA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 THR A 494
SER A 489
ASP A 366
ALA A 365
ILE A 432
 None
B12  A 803 (-3.1A)
None
None
None
 1.17A 3id6C-4rasA:
undetectable		 3id6C-4rasA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 3jt4A-4rasA:
undetectable
3jt4B-4rasA:
undetectable		 3jt4A-4rasA:
19.02
3jt4B-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 3jt5A-4rasA:
undetectable
3jt5B-4rasA:
undetectable		 3jt5A-4rasA:
19.02
3jt5B-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 3jt7A-4rasA:
undetectable
3jt7B-4rasA:
undetectable		 3jt7A-4rasA:
19.02
3jt7B-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 3jwxA-4rasA:
undetectable
3jwxB-4rasA:
0.7		 3jwxA-4rasA:
20.63
3jwxB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 3jwzA-4rasA:
undetectable
3jwzB-4rasA:
undetectable		 3jwzA-4rasA:
20.63
3jwzB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.48A 3jwzA-4rasA:
undetectable
3jwzB-4rasA:
undetectable		 3jwzA-4rasA:
20.63
3jwzB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 3jx1A-4rasA:
undetectable
3jx1B-4rasA:
undetectable		 3jx1A-4rasA:
19.02
3jx1B-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ARG A 206
GLY A 208
GLN A  34
LEU A 182
ALA A 175
 None
 1.01A 3kkzA-4rasA:
undetectable		 3kkzA-4rasA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 11 GLN A  30
ALA A  32
ALA A 186
GLY A 187
ALA A 189
 None
 1.15A 3mg0V-4rasA:
undetectable
3mg0W-4rasA:
undetectable		 3mg0V-4rasA:
15.67
3mg0W-4rasA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 3n5rA-4rasA:
undetectable
3n5rB-4rasA:
undetectable		 3n5rA-4rasA:
20.63
3n5rB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.47A 3n5rA-4rasA:
undetectable
3n5rB-4rasA:
undetectable		 3n5rA-4rasA:
20.63
3n5rB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.46A 3n5sA-4rasA:
undetectable
3n5sB-4rasA:
0.6		 3n5sA-4rasA:
20.63
3n5sB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.41A 3n5tA-4rasA:
undetectable
3n5tB-4rasA:
undetectable		 3n5tA-4rasA:
20.63
3n5tB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.48A 3n5tA-4rasA:
undetectable
3n5tB-4rasA:
undetectable		 3n5tA-4rasA:
20.63
3n5tB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.40A 3n5vA-4rasA:
undetectable
3n5vB-4rasA:
undetectable		 3n5vA-4rasA:
19.02
3n5vB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.45A 3n5yA-4rasA:
undetectable
3n5yB-4rasA:
undetectable		 3n5yA-4rasA:
19.02
3n5yB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.43A 3n5zA-4rasA:
undetectable
3n5zB-4rasA:
undetectable		 3n5zA-4rasA:
19.02
3n5zB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N68_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.44A 3n68A-4rasA:
0.0
3n68B-4rasA:
0.0		 3n68A-4rasA:
20.63
3n68B-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N68_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.45A 3n68A-4rasA:
0.0
3n68B-4rasA:
0.0		 3n68A-4rasA:
20.63
3n68B-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.47A 3n6aA-4rasA:
0.0
3n6aB-4rasA:
0.0		 3n6aA-4rasA:
20.63
3n6aB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.48A 3n6eA-4rasA:
undetectable
3n6eB-4rasA:
undetectable		 3n6eA-4rasA:
20.78
3n6eB-4rasA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 3nlgA-4rasA:
undetectable
3nlgB-4rasA:
undetectable		 3nlgA-4rasA:
20.63
3nlgB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.47A 3nlgA-4rasA:
undetectable
3nlgB-4rasA:
0.5		 3nlgA-4rasA:
20.63
3nlgB-4rasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.45A 3q9aA-4rasA:
undetectable
3q9aB-4rasA:
undetectable		 3q9aA-4rasA:
19.02
3q9aB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 11 ASP A 394
ASP A 495
LYS A 336
TYR A 392
ALA A 373
 None
 1.45A 3r2jD-4rasA:
undetectable		 3r2jD-4rasA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 3rqoA-4rasA:
undetectable
3rqoB-4rasA:
undetectable		 3rqoA-4rasA:
20.66
3rqoB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 PHE A 367
ILE A 356
LEU A 359
LYS A 357
 None
 1.34A 3sueC-4rasA:
undetectable		 3sueC-4rasA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 10 ASP A 178
ALA A 180
VAL A 184
GLY A 194
ALA A  29
 None
 1.04A 3t3cB-4rasA:
undetectable		 3t3cB-4rasA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 SER A 422
GLY A 413
GLY A 558
ALA A 560
GLY A 562
 B12  A 803 (-3.4A)
None
None
None
B12  A 803 (-3.5A)
 1.05A 3tegA-4rasA:
undetectable		 3tegA-4rasA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 ASP A 415
SER A 418
TRP A 614
ASP A 616
 None
B12  A 803 ( 4.6A)
None
None
 1.44A 3w9tB-4rasA:
undetectable		 3w9tB-4rasA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 ASP A 415
SER A 418
TRP A 614
ASP A 616
 None
B12  A 803 ( 4.6A)
None
None
 1.45A 3w9tC-4rasA:
undetectable		 3w9tC-4rasA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 ASP A 415
SER A 418
TRP A 614
ASP A 616
 None
B12  A 803 ( 4.6A)
None
None
 1.45A 3w9tD-4rasA:
undetectable		 3w9tD-4rasA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4c3aA-4rasA:
undetectable
4c3aB-4rasA:
undetectable		 4c3aA-4rasA:
20.66
4c3aB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4carA-4rasA:
undetectable
4carB-4rasA:
undetectable		 4carA-4rasA:
20.66
4carB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.50A 4cftA-4rasA:
undetectable
4cftB-4rasA:
undetectable		 4cftA-4rasA:
20.66
4cftB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 4ctyA-4rasA:
undetectable
4ctyB-4rasA:
undetectable		 4ctyA-4rasA:
20.66
4ctyB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 4cwvA-4rasA:
undetectable
4cwvB-4rasA:
0.8		 4cwvA-4rasA:
20.66
4cwvB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 4cwwA-4rasA:
undetectable
4cwwB-4rasA:
undetectable		 4cwwA-4rasA:
20.66
4cwwB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4cwwA-4rasA:
undetectable
4cwwB-4rasA:
undetectable		 4cwwA-4rasA:
20.66
4cwwB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.50A 4cwxA-4rasA:
undetectable
4cwxB-4rasA:
undetectable		 4cwxA-4rasA:
20.66
4cwxB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.45A 4d1nA-4rasA:
undetectable
4d1nB-4rasA:
undetectable		 4d1nA-4rasA:
19.44
4d1nB-4rasA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4d1nA-4rasA:
undetectable
4d1nB-4rasA:
undetectable		 4d1nA-4rasA:
19.44
4d1nB-4rasA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.48A 4d1nC-4rasA:
undetectable
4d1nD-4rasA:
undetectable		 4d1nC-4rasA:
19.44
4d1nD-4rasA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4d1oA-4rasA:
undetectable
4d1oB-4rasA:
undetectable		 4d1oA-4rasA:
20.90
4d1oB-4rasA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.48A 4d33A-4rasA:
undetectable
4d33B-4rasA:
undetectable		 4d33A-4rasA:
20.66
4d33B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 4d34A-4rasA:
undetectable
4d34B-4rasA:
undetectable		 4d34A-4rasA:
20.66
4d34B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.50A 4d36A-4rasA:
undetectable
4d36B-4rasA:
0.3		 4d36A-4rasA:
20.66
4d36B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.50A 4d37A-4rasA:
undetectable
4d37B-4rasA:
0.0		 4d37A-4rasA:
20.66
4d37B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4d39A-4rasA:
undetectable
4d39B-4rasA:
undetectable		 4d39A-4rasA:
20.66
4d39B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 4d3bA-4rasA:
undetectable
4d3bB-4rasA:
undetectable		 4d3bA-4rasA:
19.02
4d3bB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 4 ALA A 438
VAL A 435
ASP A  49
LEU A 359
 None
 1.18A 4e7gA-4rasA:
undetectable		 4e7gA-4rasA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 11 HIS A 459
SER A 489
ILE A 463
ASP A 501
GLY A 369
 B12  A 803 (-4.0A)
B12  A 803 (-3.1A)
B12  A 803 (-4.5A)
None
None
 1.39A 4fogA-4rasA:
undetectable		 4fogA-4rasA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 11 HIS A 459
SER A 489
ILE A 463
ASP A 501
GLY A 369
 B12  A 803 (-4.0A)
B12  A 803 (-3.1A)
B12  A 803 (-4.5A)
None
None
 1.41A 4foxH-4rasA:
undetectable		 4foxH-4rasA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 8 ASP A 574
ASP A  91
ARG A 424
GLU A 251
 None
 1.16A 4gkhF-4rasA:
undetectable		 4gkhF-4rasA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.50A 4imxA-4rasA:
undetectable
4imxB-4rasA:
undetectable		 4imxA-4rasA:
20.24
4imxB-4rasA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 4jsmA-4rasA:
undetectable
4jsmB-4rasA:
undetectable		 4jsmA-4rasA:
20.66
4jsmB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.47A 4k5hA-4rasA:
undetectable
4k5hB-4rasA:
0.5		 4k5hA-4rasA:
20.66
4k5hB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4k5iA-4rasA:
undetectable
4k5iB-4rasA:
undetectable		 4k5iA-4rasA:
20.66
4k5iB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 4k5kA-4rasA:
undetectable
4k5kB-4rasA:
undetectable		 4k5kA-4rasA:
20.66
4k5kB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 4kcqA-4rasA:
undetectable
4kcqB-4rasA:
undetectable		 4kcqA-4rasA:
20.66
4kcqB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4kcrA-4rasA:
0.3
4kcrB-4rasA:
undetectable		 4kcrA-4rasA:
20.66
4kcrB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.50A 4kcsA-4rasA:
undetectable
4kcsB-4rasA:
undetectable		 4kcsA-4rasA:
20.66
4kcsB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.07A 4lnwA-4rasA:
undetectable		 4lnwA-4rasA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ILE A 432
ALA A 365
ALA A 358
LEU A  46
ILE A 137
 None
 1.08A 4lnxA-4rasA:
undetectable		 4lnxA-4rasA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.46A 4luwA-4rasA:
undetectable
4luwB-4rasA:
undetectable		 4luwA-4rasA:
20.06
4luwB-4rasA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		3 / 3 ILE A 432
ASP A 366
ARG A 144
 None
 0.83A 4pstA-4rasA:
undetectable		 4pstA-4rasA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 4uh5A-4rasA:
undetectable
4uh5B-4rasA:
undetectable		 4uh5A-4rasA:
19.44
4uh5B-4rasA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 4upqA-4rasA:
undetectable
4upqB-4rasA:
undetectable		 4upqA-4rasA:
20.66
4upqB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 4upqA-4rasA:
undetectable
4upqB-4rasA:
undetectable		 4upqA-4rasA:
20.66
4upqB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ASP A 402
GLY A 404
ASP A 366
PHE A 367
ILE A 483
 None
 1.14A 4wh5A-4rasA:
1.4		 4wh5A-4rasA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 1.18A 5b1bC-4rasA:
undetectable
5b1bJ-4rasA:
undetectable		 5b1bC-4rasA:
15.49
5b1bJ-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.49A 5fj2A-4rasA:
undetectable
5fj2B-4rasA:
undetectable		 5fj2A-4rasA:
20.66
5fj2B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 5fvqA-4rasA:
undetectable
5fvqB-4rasA:
undetectable		 5fvqA-4rasA:
19.02
5fvqB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.46A 5fvrA-4rasA:
undetectable
5fvrB-4rasA:
undetectable		 5fvrA-4rasA:
19.02
5fvrB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.48A 5fvsA-4rasA:
undetectable
5fvsB-4rasA:
undetectable		 5fvsA-4rasA:
19.02
5fvsB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.47A 5fvtA-4rasA:
undetectable
5fvtB-4rasA:
undetectable		 5fvtA-4rasA:
19.02
5fvtB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.46A 5fvuA-4rasA:
undetectable
5fvuB-4rasA:
undetectable		 5fvuA-4rasA:
19.44
5fvuB-4rasA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.46A 5fvvA-4rasA:
undetectable
5fvvB-4rasA:
undetectable		 5fvvA-4rasA:
19.44
5fvvB-4rasA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 148
GLU A 151
PHE A  57
VAL A 435
 None
 1.31A 5h4dA-4rasA:
undetectable		 5h4dA-4rasA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 VAL A 209
CYH A  98
HIS A 113
LEU A 100
 None
 1.19A 5hrqH-4rasA:
undetectable
5hrqK-4rasA:
undetectable
5hrqL-4rasA:
undetectable		 5hrqH-4rasA:
3.62
5hrqK-4rasA:
3.00
5hrqL-4rasA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 12 ILE A 137
ALA A 438
VAL A 435
GLY A 444
THR A 340
 None
 1.44A 5igpA-4rasA:
undetectable		 5igpA-4rasA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 351
LEU A 496
GLU A 354
ALA A 355
 None
 0.67A 5jq7A-4rasA:
undetectable		 5jq7A-4rasA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A  79
ARG A  78
ALA A  77
PRO A  76
 None
 1.23A 5odqA-4rasA:
undetectable		 5odqA-4rasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 GLY A 475
ARG A 473
ASP A 476
GLN A 658
 B12  A 803 ( 4.3A)
None
B12  A 803 (-3.3A)
None
 1.11A 5ubbA-4rasA:
undetectable		 5ubbA-4rasA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 VAL A 457
ARG A 334
TYR A 392
GLU A 456
 None
 0.96A 5umwB-4rasA:
0.7
5umwE-4rasA:
1.3		 5umwB-4rasA:
7.50
5umwE-4rasA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.37A 5unvA-4rasA:
undetectable
5unvB-4rasA:
undetectable		 5unvA-4rasA:
19.02
5unvB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 5uo8A-4rasA:
undetectable
5uo8B-4rasA:
0.0		 5uo8A-4rasA:
20.90
5uo8B-4rasA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.45A 5uo8C-4rasA:
0.3
5uo8D-4rasA:
0.0		 5uo8C-4rasA:
20.90
5uo8D-4rasA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.49A 5uodA-4rasA:
undetectable
5uodB-4rasA:
undetectable		 5uodA-4rasA:
20.66
5uodB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.46A 5uodA-4rasA:
undetectable
5uodB-4rasA:
undetectable		 5uodA-4rasA:
20.66
5uodB-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 LEU A  83
LYS A  84
ALA A  87
LEU A  90
 None
 0.82A 5vkqA-4rasA:
undetectable
5vkqD-4rasA:
undetectable		 5vkqA-4rasA:
18.77
5vkqD-4rasA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 LEU A  83
LYS A  84
ALA A  87
LEU A  90
 None
 0.83A 5vkqA-4rasA:
undetectable
5vkqB-4rasA:
undetectable		 5vkqA-4rasA:
18.77
5vkqB-4rasA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 LEU A  83
LYS A  84
ALA A  87
LEU A  90
 None
 0.83A 5vkqB-4rasA:
undetectable
5vkqC-4rasA:
undetectable		 5vkqB-4rasA:
18.77
5vkqC-4rasA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 5 LEU A  83
LYS A  84
ALA A  87
LEU A  90
 None
 0.83A 5vkqC-4rasA:
undetectable
5vkqD-4rasA:
undetectable		 5vkqC-4rasA:
18.77
5vkqD-4rasA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.39A 5vujA-4rasA:
undetectable
5vujB-4rasA:
undetectable		 5vujA-4rasA:
19.02
5vujB-4rasA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.44A 5vv6A-4rasA:
undetectable
5vv6B-4rasA:
undetectable		 5vv6A-4rasA:
20.66
5vv6B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.46A 5vv8A-4rasA:
undetectable
5vv8B-4rasA:
undetectable		 5vv8A-4rasA:
20.66
5vv8B-4rasA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 7 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.48A 5vvdA-4rasA:
undetectable
5vvdB-4rasA:
0.0		 5vvdA-4rasA:
20.90
5vvdB-4rasA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 0.97A 5z84P-4rasA:
undetectable
5z84W-4rasA:
undetectable		 5z84P-4rasA:
15.49
5z84W-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 1.00A 5z85P-4rasA:
undetectable
5z85W-4rasA:
undetectable		 5z85P-4rasA:
15.49
5z85W-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 1.01A 5z86C-4rasA:
undetectable
5z86J-4rasA:
undetectable		 5z86C-4rasA:
15.49
5z86J-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 0.97A 5z86P-4rasA:
undetectable
5z86W-4rasA:
undetectable		 5z86P-4rasA:
15.49
5z86W-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 0.96A 5zcoP-4rasA:
undetectable
5zcoW-4rasA:
undetectable		 5zcoP-4rasA:
15.49
5zcoW-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 0.97A 5zcpP-4rasA:
undetectable
5zcpW-4rasA:
undetectable		 5zcpP-4rasA:
15.49
5zcpW-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 ARG A 424
TRP A 613
PHE A  89
GLU A 406
 None
 1.42A 6av6C-4rasA:
0.0
6av6D-4rasA:
0.0		 6av6C-4rasA:
8.63
6av6D-4rasA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		3 / 3 ARG A 260
ARG A 486
ARG A 579
 None
 0.90A 6bplA-4rasA:
undetectable
6bplB-4rasA:
undetectable		 6bplA-4rasA:
8.75
6bplB-4rasA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		5 / 11 GLN A  30
ALA A  32
ALA A 186
GLY A 187
ALA A 189
 None
 1.10A 6hwdV-4rasA:
undetectable		 6hwdV-4rasA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN
(Nitratireductor
pacificus) 		4 / 6 TRP A 613
PHE A  89
GLU A 406
ARG A 424
 None
 1.45A 8nseA-4rasA:
undetectable
8nseB-4rasA:
undetectable		 8nseA-4rasA:
20.63
8nseB-4rasA:
20.63