SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4rav SINGLE-CHAIN FV, VL
(Homo
sapiens) 		3 / 3 LEU B 176
SER B 192
ASN B 189
 None
 0.69A 1bx4A-4ravB:
undetectable		 1bx4A-4ravB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  95
TYR B 165
PRO B 173
TYR B 216
 None
 0.56A 2oldA-4ravA:
13.8
2oldB-4ravA:
13.8		 2oldA-4ravA:
23.50
2oldB-4ravA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B 165
PRO B 173
TYR B 216
TYR A  95
 None
 0.50A 2oldA-4ravB:
22.3
2oldB-4ravB:
21.9		 2oldA-4ravB:
41.74
2oldB-4ravB:
41.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PHE B 220
ASP B 179
ARG A 100
 None
 0.87A 4eahF-4ravB:
undetectable		 4eahF-4ravB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PHE B 220
ASP B 179
ARG A 100
 None
 0.87A 4eahG-4ravB:
undetectable		 4eahG-4ravB:
12.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL
(Homo
sapiens) 		4 / 7 TYR B 161
SER B 163
TYR B 165
TYR A 101
 None
 0.85A 5aclA-4ravB:
22.1		 5aclA-4ravB:
75.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4rav SINGLE-CHAIN FV, VL
(Homo
sapiens) 		5 / 7 TYR B 161
SER B 163
TYR B 165
TYR B 178
PRO B 184
 None
 0.48A 5aclA-4ravB:
22.1		 5aclA-4ravB:
75.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL
(Homo
sapiens) 		4 / 5 TYR B 216
GLY B 230
THR B 231
GLY A 118
 None
 0.88A 5jlcA-4ravB:
undetectable		 5jlcA-4ravB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4rav SINGLE-CHAIN FV, VL
(Homo
sapiens) 		3 / 3 ARG B 183
ILE B 187
SER B 188
 None
None
SO4  B 301 (-2.8A)
 0.68A 5zw2A-4ravB:
undetectable		 5zw2A-4ravB:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4rav SINGLE-CHAIN FV, VH
(Homo
sapiens) 		3 / 3 TYR A  60
GLY A  66
THR A  69
 None
 0.16A 6cjkB-4ravA:
20.2		 6cjkB-4ravA:
46.41