SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.37A 1hrkB-4raxA:
undetectable		 1hrkB-4raxA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 ILE A2403
ARG A2318
THR A2316
LEU A2344
 None
 0.99A 2einN-4raxA:
undetectable
2einW-4raxA:
undetectable		 2einN-4raxA:
17.03
2einW-4raxA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.35A 2hrcB-4raxA:
undetectable		 2hrcB-4raxA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.40A 2pnjB-4raxA:
undetectable		 2pnjB-4raxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 8 GLY A2360
ARG A2301
LEU A2357
LEU A2405
 None
 0.90A 3nbqB-4raxA:
undetectable		 3nbqB-4raxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 8 GLY A2360
ARG A2301
LEU A2357
LEU A2405
 None
 0.92A 3nbqC-4raxA:
undetectable		 3nbqC-4raxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 7 ASP A2264
TYR A2266
PRO A2267
GLN A2271
 None
 1.27A 3s3oA-4raxA:
undetectable		 3s3oA-4raxA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		5 / 11 ILE A2403
LEU A2232
LEU A2357
ALA A2355
LEU A2371
 None
 1.23A 5ji0A-4raxA:
undetectable		 5ji0A-4raxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1
(Mus
musculus) 		4 / 6 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.12A 5z85P-4raxA:
undetectable
5z85W-4raxA:
undetectable		 5z85P-4raxA:
19.93
5z85W-4raxA:
14.54