SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		5 / 11 GLU B 115
LEU B  56
GLU B  60
ILE B 119
GLU B 144
 FE2  B 301 (-2.0A)
None
FE2  B 301 ( 2.3A)
None
FE2  B 302 ( 2.4A)
 1.42A 1rnrA-4rc6B:
15.9		 1rnrA-4rc6B:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		4 / 7 GLU B  60
GLU B 144
TYR B  39
GLU B 115
 FE2  B 301 ( 2.3A)
FE2  B 302 ( 2.4A)
None
FE2  B 301 (-2.0A)
 1.10A 2zt7A-4rc6B:
undetectable		 2zt7A-4rc6B:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		5 / 10 TYR B  21
ILE B  27
LYS B  72
GLY B  71
LEU B 191
 None
 1.30A 3em0A-4rc6B:
undetectable		 3em0A-4rc6B:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		5 / 12 TYR B  17
LEU B 191
VAL B  28
ALA B 133
PHE B  67
 None
 1.39A 3nhxA-4rc6B:
undetectable		 3nhxA-4rc6B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		4 / 5 ALA B 118
GLU B  60
GLU B  32
ALA B  35
 None
FE2  B 301 ( 2.3A)
FE2  B 302 (-2.2A)
FE2  B 301 ( 4.3A)
 1.20A 3r9tC-4rc6B:
undetectable		 3r9tC-4rc6B:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		4 / 8 TYR B  39
LEU B  42
PHE B 150
PHE B  94
 None
 1.11A 3rqwF-4rc6B:
undetectable
3rqwJ-4rc6B:
undetectable		 3rqwF-4rc6B:
23.00
3rqwJ-4rc6B:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		4 / 8 PHE B  87
ALA B  35
PHE B 117
ALA B 118
 None
FE2  B 301 ( 4.3A)
None
None
 0.91A 3t3sD-4rc6B:
undetectable		 3t3sD-4rc6B:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		4 / 8 PHE B  87
ALA B  35
PHE B 117
ALA B 118
 None
FE2  B 301 ( 4.3A)
None
None
 0.90A 3t3sE-4rc6B:
undetectable		 3t3sE-4rc6B:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		4 / 8 GLU B  60
ILE B 114
GLN B 110
LEU B 107
 FE2  B 301 ( 2.3A)
None
None
None
 0.84A 4mj8A-4rc6B:
undetectable		 4mj8A-4rc6B:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4rc6 ALDEHYDE
DECARBONYLASE
(Synechococcus
elongatus) 		4 / 8 LEU B 108
MET B 180
LEU B  90
HIS B  91
 None
 1.05A 4ok1A-4rc6B:
undetectable		 4ok1A-4rc6B:
24.91