SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 111
LEU B 129
VAL B 108
HIS B  88
LEU B  65
 None
 1.20A 1ie9A-4rcaB:
undetectable		 1ie9A-4rcaB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 111
PHE B 102
ILE B 113
PHE B 121
 None
 0.94A 2opxA-4rcaB:
undetectable		 2opxA-4rcaB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU B 161
LEU B 184
LEU B 209
ILE B 145
VAL B 197
 None
 1.29A 2qd3A-4rcaB:
undetectable		 2qd3A-4rcaB:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 184
LEU B 208
ILE B 230
ILE B 204
LEU B 198
 None
 1.30A 4j24C-4rcaB:
undetectable		 4j24C-4rcaB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE B 118
GLU B  90
ASN B  68
ASN B 116
HIS B  95
 None
 1.34A 4jlgB-4rcaB:
undetectable		 4jlgB-4rcaB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU B 252
VAL B 239
ILE B 207
VAL B 197
LEU B 169
 None
SO4  B 301 (-3.6A)
None
None
None
 1.20A 4y0pA-4rcaB:
undetectable		 4y0pA-4rcaB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL B 239
ILE B 207
ILE B 230
VAL B 197
LEU B 169
 SO4  B 301 (-3.6A)
None
None
None
None
 1.10A 4y0pA-4rcaB:
undetectable		 4y0pA-4rcaB:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4rca SLIT AND NTRK-LIKE
PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU B 198
TYR B 176
PRO B 202
ILE B 204
 None
 1.37A 5esgA-4rcaB:
undetectable		 5esgA-4rcaB:
19.69