SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 LEU A 121
LEU A  30
MET A  18
 None
3LL  A 501 (-4.2A)
None
 0.53A 1ya3B-4rcdA:
undetectable		 1ya3B-4rcdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A  30
ASP A  32
GLY A  34
ASN A  37
ILE A 118
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
3LL  A 501 (-4.6A)
 0.79A 2f80B-4rcdA:
6.5		 2f80B-4rcdA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 213
LEU A 236
PHE A 241
SER A 325
ILE A 248
 None
 1.10A 2oipD-4rcdA:
undetectable		 2oipD-4rcdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 287
ILE A 352
LEU A 236
PRO A 237
VAL A 240
 None
 1.05A 2po5A-4rcdA:
undetectable		 2po5A-4rcdA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A  30
ASP A  32
GLY A  34
ASN A  37
ILE A 118
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
3LL  A 501 (-4.6A)
 0.75A 2q64A-4rcdA:
6.7		 2q64A-4rcdA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A  30
ASP A  32
GLY A  34
ASN A  37
ILE A 118
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
3LL  A 501 (-4.6A)
 0.86A 2qakB-4rcdA:
6.7		 2qakB-4rcdA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A  30
ASP A  32
GLY A  34
VAL A  69
ILE A 118
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
3LL  A 501 (-4.6A)
 0.66A 2rkgB-4rcdA:
6.9		 2rkgB-4rcdA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A  32
GLY A  34
SER A  35
ASP A 228
GLY A 230
 3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
3LL  A 501 ( 4.3A)
3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
 0.32A 2v0zC-4rcdA:
34.5		 2v0zC-4rcdA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		6 / 12 ASP A 228
GLY A 230
VAL A 332
ASP A  32
GLY A  34
SER A  36
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
None
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
 1.04A 2v0zC-4rcdA:
34.5		 2v0zC-4rcdA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		6 / 12 ASP A 228
GLY A 230
VAL A 332
ASP A  32
GLY A  34
SER A  36
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
None
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
 1.03A 2v0zO-4rcdA:
34.6		 2v0zO-4rcdA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 11 ILE A 208
ALA A 243
LEU A 236
ILE A 203
LEU A 285
 None
 1.32A 2zzaB-4rcdA:
undetectable		 2zzaB-4rcdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		4 / 8 GLY A 177
VAL A 146
LEU A 140
PRO A  91
 None
 1.15A 3bgdB-4rcdA:
undetectable		 3bgdB-4rcdA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 5 LEU A  30
ASP A  32
ILE A 110
ILE A 118
GLY A 230
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
None
3LL  A 501 (-4.6A)
3LL  A 501 (-3.0A)
 0.12A 3bufA-4rcdA:
60.0		 3bufA-4rcdA:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 GLY A 120
ILE A 176
MET A  18
LEU A   6
LEU A 152
 None
 1.14A 3cs8A-4rcdA:
undetectable		 3cs8A-4rcdA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 228
GLY A 230
LEU A  30
ASP A  32
SER A  36
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
None
 0.73A 3d91A-4rcdA:
34.7		 3d91A-4rcdA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 228
GLY A 230
THR A  72
LEU A  30
ASP A  32
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
None
3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
 1.08A 3d91A-4rcdA:
34.7		 3d91A-4rcdA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 228
GLY A 230
LEU A  30
ASP A  32
SER A  36
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
None
 0.72A 3d91B-4rcdA:
34.3		 3d91B-4rcdA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		6 / 12 ASP A 228
GLY A 230
THR A  72
VAL A 332
LEU A  30
ASP A  32
 3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
None
None
3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
 1.06A 3d91B-4rcdA:
34.3		 3d91B-4rcdA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TYR A  15
GLY A  41
VAL A  40
GLY A 117
HIS A  49
 None
 1.07A 3f8wB-4rcdA:
undetectable		 3f8wB-4rcdA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 121
ASP A  32
VAL A  31
GLY A  34
TYR A 199
 None
3LL  A 501 (-2.8A)
None
3LL  A 501 ( 3.9A)
None
 1.36A 3hgiA-4rcdA:
undetectable		 3hgiA-4rcdA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 213
LEU A 236
PHE A 241
SER A 325
ILE A 248
 None
 1.17A 3hj3A-4rcdA:
undetectable		 3hj3A-4rcdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 213
LEU A 236
PHE A 241
SER A 325
ILE A 248
 None
 1.16A 3hj3B-4rcdA:
undetectable		 3hj3B-4rcdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TYR A 190
ASN A   5
ILE A  87
GLY A 177
LEU A 152
 None
 0.98A 3hs6B-4rcdA:
undetectable		 3hs6B-4rcdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 11 MET A 215
LEU A 285
LEU A 236
VAL A 240
ILE A 208
 None
 1.33A 3jw5A-4rcdA:
undetectable		 3jw5A-4rcdA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		4 / 8 GLY A  34
SER A  35
ASP A 228
THR A 232
 3LL  A 501 ( 3.9A)
3LL  A 501 ( 4.3A)
3LL  A 501 (-2.6A)
GOL  A 506 ( 4.3A)
 0.24A 3pwwA-4rcdA:
32.4		 3pwwA-4rcdA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 226
ASP A 228
GLY A 230
ASP A  32
ILE A 118
 None
3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
3LL  A 501 (-2.8A)
3LL  A 501 (-4.6A)
 0.65A 3q70A-4rcdA:
8.9		 3q70A-4rcdA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 10 LEU A  30
ASP A  32
GLY A  34
VAL A  69
ILE A 118
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
3LL  A 501 (-4.6A)
 0.80A 3s43B-4rcdA:
6.3		 3s43B-4rcdA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 226
ASP A 228
GLY A 230
ASP A  32
ILE A 118
 None
3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
3LL  A 501 (-2.8A)
3LL  A 501 (-4.6A)
 0.67A 3tneA-4rcdA:
32.6		 3tneA-4rcdA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 226
ASP A 228
GLY A 230
ASP A  32
ILE A 118
 None
3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
3LL  A 501 (-2.8A)
3LL  A 501 (-4.6A)
 0.67A 3tneB-4rcdA:
32.5		 3tneB-4rcdA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TRP A 262
VAL A 245
ILE A 283
VAL A 206
LEU A 285
 None
 1.03A 3w68A-4rcdA:
undetectable		 3w68A-4rcdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TRP A 262
VAL A 245
ILE A 283
VAL A 206
LEU A 285
 None
 0.92A 3w68D-4rcdA:
undetectable		 3w68D-4rcdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 118
GLN A  73
THR A 231
TYR A 198
ILE A 226
 3LL  A 501 (-4.6A)
None
None
None
None
 1.08A 4g1bD-4rcdA:
undetectable		 4g1bD-4rcdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 298
LEU A 236
PRO A 237
VAL A 240
THR A 191
 None
 1.03A 4m2xG-4rcdA:
undetectable		 4m2xG-4rcdA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 9 VAL A  95
ILE A 118
VAL A  40
ALA A  39
ALA A  97
 None
3LL  A 501 (-4.6A)
None
None
None
 1.29A 4oqrA-4rcdA:
undetectable		 4oqrA-4rcdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 ASP A  32
ASP A 228
ASN A 233
 3LL  A 501 (-2.8A)
3LL  A 501 (-2.6A)
None
 0.57A 4q5mA-4rcdA:
9.3		 4q5mA-4rcdA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 ASP A 228
ASP A  32
ASN A  37
 3LL  A 501 (-2.6A)
3LL  A 501 (-2.8A)
None
 0.62A 4q5mA-4rcdA:
9.3		 4q5mA-4rcdA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 11 LEU A 133
GLY A 120
LEU A 121
PHE A  38
ALA A  97
 None
 1.21A 4wnuA-4rcdA:
undetectable		 4wnuA-4rcdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 GLY A 120
PRO A 135
ALA A 127
LEU A  30
LEU A 121
 None
None
None
3LL  A 501 (-4.2A)
None
 1.19A 5bw4B-4rcdA:
undetectable		 5bw4B-4rcdA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A  30
ASP A  32
GLY A  34
VAL A  69
ILE A 118
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
3LL  A 501 (-4.6A)
 0.80A 5e5jA-4rcdA:
6.5		 5e5jA-4rcdA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4rcd BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A  30
ASP A  32
GLY A  34
VAL A  69
ILE A 118
 3LL  A 501 (-4.2A)
3LL  A 501 (-2.8A)
3LL  A 501 ( 3.9A)
None
3LL  A 501 (-4.6A)
 0.85A 5t8hA-4rcdA:
6.4		 5t8hA-4rcdA:
15.43