SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens) 		4 / 7 SER A 398
ASP A 400
SER A 396
TRP A 411
 None
 1.15A 2cmlA-4rcjA:
undetectable		 2cmlA-4rcjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 398
ASP A 400
SER A 396
TRP A 411
 None
 1.12A 2cmlB-4rcjA:
undetectable		 2cmlB-4rcjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 398
ASP A 400
SER A 396
TRP A 411
 None
 1.14A 2cmlD-4rcjA:
undetectable		 2cmlD-4rcjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 536
ILE A 406
TRP A 478
ASP A 483
PHE A 533
 None
 1.13A 4eb4A-4rcjA:
undetectable		 4eb4A-4rcjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 536
ILE A 406
TRP A 478
ASP A 483
PHE A 533
 None
 1.11A 4eb4B-4rcjA:
undetectable		 4eb4B-4rcjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 421
PHE A 425
LEU A 436
PHE A 438
 None
 1.18A 5iy5P-4rcjA:
undetectable
5iy5W-4rcjA:
undetectable		 5iy5P-4rcjA:
21.05
5iy5W-4rcjA:
15.64