SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		3 / 3 ASP A  70
PHE A  68
ASN A  95
 None
 0.79A 1sg9B-4rckA:
undetectable		 1sg9B-4rckA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 10 GLU A 105
GLY A 108
LEU A 107
HIS A  71
TYR A  73
 None
 1.20A 2h21A-4rckA:
undetectable		 2h21A-4rckA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 11 LEU A  63
LEU A  20
VAL A  22
ILE A  55
ASP A  90
 None
 0.96A 2q6hA-4rckA:
undetectable		 2q6hA-4rckA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 11 LEU A  63
LEU A  20
VAL A  22
ILE A  55
ASP A  90
 None
 1.02A 2q72A-4rckA:
undetectable		 2q72A-4rckA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 12 LEU A  63
LEU A  20
VAL A  22
ILE A  55
ASP A  90
 None
 1.04A 2qb4A-4rckA:
undetectable		 2qb4A-4rckA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 11 LEU A  63
LEU A  20
VAL A  22
ILE A  55
ASP A  90
 None
 1.04A 2qeiA-4rckA:
undetectable		 2qeiA-4rckA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		4 / 8 PRO A 139
ALA A 143
ALA A 146
ILE A 188
 None
 0.59A 3dtuC-4rckA:
undetectable
3dtuD-4rckA:
undetectable		 3dtuC-4rckA:
17.99
3dtuD-4rckA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 12 LEU A  63
GLY A  64
LEU A  20
GLN A  75
ILE A  55
 None
 0.92A 3gwvA-4rckA:
undetectable		 3gwvA-4rckA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 12 LEU A  63
GLY A  64
LEU A  20
ILE A  55
ASP A  90
 None
 0.76A 3gwvA-4rckA:
undetectable		 3gwvA-4rckA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 12 LEU A  63
GLY A  64
LEU A  20
ILE A  55
ASP A  90
 None
 0.78A 3gwwA-4rckA:
undetectable		 3gwwA-4rckA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		4 / 7 LEU A  63
VAL A  66
GLN A  88
GLU A  87
 None
 1.08A 5tudA-4rckA:
undetectable		 5tudA-4rckA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Aliivibrio
fischeri) 		5 / 10 ARG A  43
ILE A 103
ASP A  70
GLY A  69
PHE A  68
 None
 1.23A 5x66D-4rckA:
undetectable		 5x66D-4rckA:
20.62