SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 168
VAL A 243
GLY A 175
TRP A 245
 None
None
UNX  A 405 ( 4.2A)
None
 1.11A 2p2fA-4rcmA:
undetectable		 2p2fA-4rcmA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 175
CYH A 213
PHE A 212
PHE A 290
 UNX  A 405 ( 4.2A)
None
None
None
 1.06A 3ko0D-4rcmA:
undetectable
3ko0E-4rcmA:
undetectable		 3ko0D-4rcmA:
22.02
3ko0E-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 289
ILE A 251
PHE A 204
PHE A 203
PHE A 157
 None
 1.37A 3ko0G-4rcmA:
undetectable
3ko0H-4rcmA:
undetectable
3ko0I-4rcmA:
undetectable
3ko0J-4rcmA:
undetectable		 3ko0G-4rcmA:
22.02
3ko0H-4rcmA:
22.02
3ko0I-4rcmA:
22.02
3ko0J-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 175
CYH A 213
PHE A 212
PHE A 290
 UNX  A 405 ( 4.2A)
None
None
None
 1.10A 3ko0B-4rcmA:
undetectable
3ko0J-4rcmA:
undetectable		 3ko0B-4rcmA:
22.02
3ko0J-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 175
CYH A 213
PHE A 212
PHE A 290
 UNX  A 405 ( 4.2A)
None
None
None
 1.02A 3ko0K-4rcmA:
undetectable
3ko0S-4rcmA:
undetectable		 3ko0K-4rcmA:
22.02
3ko0S-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 175
CYH A 213
PHE A 212
PHE A 290
 UNX  A 405 ( 4.2A)
None
None
None
 1.07A 3ko0L-4rcmA:
undetectable
3ko0N-4rcmA:
undetectable		 3ko0L-4rcmA:
22.02
3ko0N-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 175
CYH A 213
PHE A 212
PHE A 290
 UNX  A 405 ( 4.2A)
None
None
None
 1.13A 3ko0K-4rcmA:
undetectable
3ko0S-4rcmA:
undetectable		 3ko0K-4rcmA:
22.02
3ko0S-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 175
CYH A 213
PHE A 212
PHE A 290
 UNX  A 405 ( 4.2A)
None
None
None
 1.11A 3ko0R-4rcmA:
undetectable
3ko0T-4rcmA:
undetectable		 3ko0R-4rcmA:
22.02
3ko0T-4rcmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 274
CYH A 213
PHE A 212
LEU A 165
 None
None
None
UNX  A 401 ( 4.7A)
 1.02A 3m0wE-4rcmA:
undetectable
3m0wF-4rcmA:
undetectable
3m0wG-4rcmA:
undetectable
3m0wH-4rcmA:
undetectable		 3m0wE-4rcmA:
22.29
3m0wF-4rcmA:
22.29
3m0wG-4rcmA:
22.29
3m0wH-4rcmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 203
ILE A 247
PHE A 201
PHE A 157
 None
 1.21A 4fgkA-4rcmA:
undetectable		 4fgkA-4rcmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4rcm METHYLATED
RNA-BINDING PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 149
GLU A 217
SER A 155
VAL A 215
 None
 0.87A 4wnvD-4rcmA:
undetectable		 4wnvD-4rcmA:
17.06