SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 5 ARG A 688
LYS A 692
ALA A 691
GLY A 686
 None
 1.02A 1e7bA-4rcnA:
undetectable		 1e7bA-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 ARG A 853
ALA A1041
ALA A1012
GLU A1010
 None
 1.18A 1e7bA-4rcnA:
undetectable		 1e7bA-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 ARG A 853
ALA A1041
ALA A1012
GLU A1010
 None
 1.12A 1e7bB-4rcnA:
undetectable		 1e7bB-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 5 ARG A 853
ALA A1041
ALA A1012
GLU A1010
 None
 1.17A 1e7cA-4rcnA:
undetectable		 1e7cA-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ARG A 389
VAL A 430
LEU A 402
ALA A 403
PHE A 428
 None
 1.00A 1gseB-4rcnA:
undetectable		 1gseB-4rcnA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 6 PHE A 286
GLU A 288
LEU A 112
VAL A 267
 None
 0.92A 1hk1A-4rcnA:
undetectable		 1hk1A-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 7 PHE A 286
GLU A 288
LEU A 112
VAL A 267
 None
 0.88A 1hk3A-4rcnA:
undetectable		 1hk3A-4rcnA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 LEU A 112
PRO A 291
LEU A 109
ARG A 107
 None
 1.40A 1hrkB-4rcnA:
2.2		 1hrkB-4rcnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 7 LEU A 306
ILE A 347
THR A 303
GLN A 246
 None
 1.30A 1kglA-4rcnA:
undetectable		 1kglA-4rcnA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ASP A 936
GLU A 874
TRP A 999
TYR A 857
HIS A 860
 None
 1.20A 1maaA-4rcnA:
undetectable		 1maaA-4rcnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		3 / 3 PHE A 927
TYR A 826
PRO A 745
 None
 1.18A 1mcnA-4rcnA:
undetectable
1mcnB-4rcnA:
undetectable
1mcnP-4rcnA:
undetectable		 1mcnA-4rcnA:
12.66
1mcnB-4rcnA:
12.66
1mcnP-4rcnA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 10 ASN A 900
ILE A 909
GLY A 981
GLU A1003
GLY A1008
 None
 1.20A 1mehA-4rcnA:
undetectable		 1mehA-4rcnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ALA A1012
ARG A1014
PHE A1034
LEU A 854
TYR A 978
 None
 1.47A 1u70A-4rcnA:
undetectable		 1u70A-4rcnA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 HIS A 690
THR A 684
LYS A 717
ASP A 720
GLY A 728
 None
 1.42A 1v8bA-4rcnA:
3.1		 1v8bA-4rcnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 HIS A 690
THR A 684
LYS A 717
ASP A 720
GLY A 728
 None
 1.41A 1v8bB-4rcnA:
3.0		 1v8bB-4rcnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 HIS A 690
THR A 684
LYS A 717
ASP A 720
GLY A 728
 None
 1.43A 1v8bD-4rcnA:
3.2		 1v8bD-4rcnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 6 ARG A 254
ILE A 330
GLY A 329
ALA A 328
 None
 1.00A 1wpuA-4rcnA:
undetectable		 1wpuA-4rcnA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 6 ARG A 254
ILE A 330
GLY A 329
ALA A 328
 None
 0.99A 1wrqA-4rcnA:
undetectable		 1wrqA-4rcnA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 LEU A 112
PRO A 291
LEU A 109
ARG A 107
 None
 1.39A 2hrcB-4rcnA:
undetectable		 2hrcB-4rcnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ILE A  18
LEU A  15
GLY A  11
SER A  39
ALA A  44
 None
 0.96A 2oc8A-4rcnA:
undetectable		 2oc8A-4rcnA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 LEU A 112
PRO A 291
LEU A 109
ARG A 107
 None
 1.41A 2pnjB-4rcnA:
2.3		 2pnjB-4rcnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		3 / 3 GLU A 241
GLN A 237
ARG A 234
 None
 0.97A 2w3bB-4rcnA:
undetectable		 2w3bB-4rcnA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 8 LYS A 238
ASN A 290
ARG A 292
GLU A 296
 None
 0.96A 2ys6A-4rcnA:
27.4		 2ys6A-4rcnA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 GLY A1002
ALA A1051
LEU A1048
ASP A 936
VAL A 849
 None
 1.04A 2zulA-4rcnA:
undetectable		 2zulA-4rcnA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 8 LEU A 746
ARG A 743
ALA A 700
ALA A 701
 None
 0.83A 3ax9B-4rcnA:
3.9		 3ax9B-4rcnA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 VAL A 459
ARG A 352
ILE A 349
THR A 456
 None
 1.09A 3cl9A-4rcnA:
undetectable		 3cl9A-4rcnA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 GLY A1002
ALA A1051
LEU A1048
ASP A 936
VAL A 849
 None
 1.01A 3dmhA-4rcnA:
undetectable		 3dmhA-4rcnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ILE A1004
ALA A1050
LEU A1056
ALA A1051
LEU A1009
 None
 1.03A 3dzyA-4rcnA:
undetectable		 3dzyA-4rcnA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 LEU A 761
ASP A 694
LEU A 652
GLY A 686
PHE A 734
 None
 1.30A 3g1uC-4rcnA:
5.6		 3g1uC-4rcnA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 LEU A 761
ASP A 694
LEU A 652
GLY A 686
PHE A 734
 None
 1.25A 3g1uD-4rcnA:
2.9		 3g1uD-4rcnA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 LEU A 761
ASP A 694
LEU A 652
GLY A 686
PHE A 734
 None
 1.36A 3glqA-4rcnA:
3.1		 3glqA-4rcnA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		3 / 3 PRO A 377
PHE A 374
ALA A 403
 None
 0.67A 3itaD-4rcnA:
undetectable		 3itaD-4rcnA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 LEU A 761
ASP A 694
LEU A 652
GLY A 686
PHE A 734
 None
 1.30A 3n58A-4rcnA:
5.7		 3n58A-4rcnA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 VAL A 747
ALA A 762
ILE A 776
THR A 771
ILE A 769
 None
 1.19A 3qfxA-4rcnA:
undetectable		 3qfxA-4rcnA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 VAL A 747
ALA A 762
ILE A 776
THR A 771
ILE A 769
 None
 1.17A 3qfxB-4rcnA:
undetectable		 3qfxB-4rcnA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 8 GLN A 524
VAL A 517
VAL A 500
GLN A 514
 None
 1.12A 3uy4A-4rcnA:
4.9		 3uy4A-4rcnA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		3 / 3 ASP A 915
LYS A 916
ASP A 919
 None
 0.83A 4a7tA-4rcnA:
undetectable		 4a7tA-4rcnA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ILE A 330
ALA A 331
ALA A 265
GLY A 268
ALA A 260
 None
 1.08A 4enhA-4rcnA:
undetectable		 4enhA-4rcnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		3 / 4 SER A 933
GLY A 939
GLU A1010
 None
 0.63A 4juoA-4rcnA:
1.9
4juoC-4rcnA:
undetectable		 4juoA-4rcnA:
19.09
4juoC-4rcnA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ALA A  45
ALA A  44
LEU A  15
ALA A  30
VAL A 309
 None
 0.97A 4k6iA-4rcnA:
undetectable		 4k6iA-4rcnA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 6 GLU A 296
ARG A 352
GLU A 208
GLU A 276
 None
 1.40A 4kr3A-4rcnA:
3.5		 4kr3A-4rcnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		6 / 12 LEU A 444
ILE A 240
ASN A 354
PHE A 439
GLY A 438
LEU A 425
 None
 1.38A 4lmnA-4rcnA:
2.3		 4lmnA-4rcnA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		6 / 7 LYS A 238
ASN A 290
ARG A 292
VAL A 295
GLU A 296
ARG A 352
 None
 0.67A 4mv7A-4rcnA:
52.9		 4mv7A-4rcnA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		6 / 7 LYS A 238
ASN A 290
GLN A 294
VAL A 295
GLU A 296
ARG A 352
 None
 0.78A 4mv7A-4rcnA:
52.9		 4mv7A-4rcnA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 5 ILE A 293
ARG A 352
ASP A 399
VAL A   7
 None
 1.24A 4nkxC-4rcnA:
undetectable		 4nkxC-4rcnA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 5 ILE A 293
ARG A 352
ASP A 399
VAL A   7
 None
 1.22A 4nkxD-4rcnA:
undetectable		 4nkxD-4rcnA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ASN A 613
GLY A 752
ALA A 774
ALA A 819
VAL A 820
 None
 1.04A 4ryaA-4rcnA:
undetectable		 4ryaA-4rcnA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ASN A   9
ARG A  19
ILE A  17
ASP A 307
ILE A 293
 None
 1.35A 4uroA-4rcnA:
undetectable		 4uroA-4rcnA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 ASN A   9
ARG A  19
ILE A  17
ASP A 307
ILE A 293
 None
 1.32A 4uroB-4rcnA:
undetectable		 4uroB-4rcnA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 11 LEU A 533
TYR A 509
GLU A 488
LEU A 553
LEU A 515
 None
 1.14A 4wg0K-4rcnA:
undetectable
4wg0L-4rcnA:
undetectable
4wg0M-4rcnA:
undetectable		 4wg0K-4rcnA:
1.74
4wg0L-4rcnA:
1.74
4wg0M-4rcnA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 GLY A 981
LEU A 921
PHE A 920
ILE A 898
 None
 0.82A 4xv2A-4rcnA:
undetectable		 4xv2A-4rcnA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 5 ALA A1041
ARG A 853
ALA A1012
GLU A1010
 None
 1.43A 5a06C-4rcnA:
3.3
5a06D-4rcnA:
3.2		 5a06C-4rcnA:
15.13
5a06D-4rcnA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 7 SER A1065
ASP A 936
ARG A 975
GLY A1002
 None
 0.82A 5btaA-4rcnA:
1.7
5btaC-4rcnA:
1.7
5btaD-4rcnA:
undetectable		 5btaA-4rcnA:
19.53
5btaC-4rcnA:
19.53
5btaD-4rcnA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 7 SER A1065
ASP A 936
ARG A 975
GLY A1002
 None
 0.84A 5btfA-4rcnA:
undetectable
5btfB-4rcnA:
undetectable
5btfC-4rcnA:
undetectable		 5btfA-4rcnA:
19.53
5btfB-4rcnA:
13.26
5btfC-4rcnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 4 ASP A 227
ILE A 207
ARG A 205
ARG A 253
 None
 1.37A 5m67C-4rcnA:
0.5		 5m67C-4rcnA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 12 HIS A 690
THR A 684
LYS A 717
ASP A 720
GLY A 728
 None
 1.32A 5utuF-4rcnA:
4.2		 5utuF-4rcnA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		5 / 9 ALA A 125
VAL A 261
ALA A 265
VAL A 337
SER A 332
 None
 1.24A 6bklA-4rcnA:
undetectable
6bklB-4rcnA:
undetectable
6bklC-4rcnA:
undetectable
6bklD-4rcnA:
undetectable		 6bklA-4rcnA:
3.98
6bklB-4rcnA:
3.98
6bklC-4rcnA:
3.98
6bklD-4rcnA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 6 GLN A 825
VAL A 767
LEU A 834
PRO A 894
 None
 1.05A 6brdB-4rcnA:
undetectable		 6brdB-4rcnA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 7 ARG A 586
HIS A 587
GLU A 582
GLU A 640
 None
 1.01A 6mn4F-4rcnA:
undetectable		 6mn4F-4rcnA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 6 ASP A 385
GLU A 301
ASP A 307
GLU A  23
 None
 1.41A 6mn5A-4rcnA:
undetectable		 6mn5A-4rcnA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		4 / 7 ALA A 917
GLY A 918
LEU A 961
GLY A 896
 None
 0.67A 6nm4A-4rcnA:
undetectable		 6nm4A-4rcnA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE
(Mycobacterium
avium) 		3 / 3 ASP A 642
LEU A 643
ARG A 717
 None
 0.89A 7dfrA-4rcnA:
undetectable		 7dfrA-4rcnA:
10.28