SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4rco PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 7 GLY A 139
ASP A 168
TYR A 172
THR A 202
 None
 1.17A 2aouB-4rcoA:
undetectable		 2aouB-4rcoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4rco PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 GLU A 187
TYR A 127
VAL A 185
PHE A 247
ASP A 246
 None
 1.42A 2qeoA-4rcoA:
undetectable		 2qeoA-4rcoA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rco PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A 300
LEU A 242
ILE A 268
ARG A 250
ILE A 303
 None
SIA  A 404 (-4.9A)
None
None
None
 1.05A 4x5jA-4rcoA:
undetectable		 4x5jA-4rcoA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4rco PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 VAL A 209
GLU A 133
GLU A 244
 None
 0.94A 5jsdB-4rcoA:
undetectable
5jsdC-4rcoA:
undetectable		 5jsdB-4rcoA:
19.01
5jsdC-4rcoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4rco PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LYS A 271
ASP A 301
ARG A 216
 None
 1.04A 5jwaA-4rcoA:
undetectable
5jwaH-4rcoA:
undetectable		 5jwaA-4rcoA:
20.11
5jwaH-4rcoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4rco PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 253
LEU A 282
ARG A 250
 None
 0.66A 6fgcA-4rcoA:
undetectable		 6fgcA-4rcoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4rco PUTATIVE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 LEU A 253
LEU A 282
ARG A 250
 None
 0.68A 6fgdA-4rcoA:
undetectable		 6fgdA-4rcoA:
22.22