SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 9 MET A  23
LEU A 125
ILE A  60
LEU A  51
PHE A  26
 None
 1.18A 3fl9D-4rctA:
undetectable		 3fl9D-4rctA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 10 MET A  23
LEU A 125
ILE A  60
LEU A  51
PHE A  26
 None
 1.13A 3fl9E-4rctA:
undetectable		 3fl9E-4rctA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 150
ALA A 152
GLY A 144
ILE A 154
SER A 109
 None
 0.93A 3gyqA-4rctA:
undetectable
3gyqB-4rctA:
undetectable		 3gyqA-4rctA:
23.42
3gyqB-4rctA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 150
ALA A 152
ILE A 154
LEU A  33
SER A 109
 None
 1.21A 3gyqA-4rctA:
undetectable
3gyqB-4rctA:
undetectable		 3gyqA-4rctA:
23.42
3gyqB-4rctA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 11 LEU A 150
ALA A 152
GLY A 144
ILE A 154
SER A 109
 None
 0.92A 3gyqB-4rctA:
undetectable		 3gyqB-4rctA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 11 LEU A 150
ALA A 152
ILE A 154
LEU A  33
SER A 109
 None
 1.23A 3gyqB-4rctA:
undetectable		 3gyqB-4rctA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 10 MET A  23
LEU A 125
ILE A  60
LEU A  51
PHE A  26
 None
 1.17A 3jw5B-4rctA:
undetectable		 3jw5B-4rctA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		4 / 4 LEU A 244
ALA A 211
PHE A 341
ASN A 220
 None
 1.35A 3vaqA-4rctA:
undetectable		 3vaqA-4rctA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		4 / 4 LEU A 244
ALA A 211
PHE A 341
ASN A 220
 None
 1.37A 3vasA-4rctA:
undetectable		 3vasA-4rctA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		4 / 7 PHE A  26
HIS A  56
ILE A  57
ARG A  92
 None
 1.39A 4o7gA-4rctA:
undetectable
4o7gB-4rctA:
undetectable		 4o7gA-4rctA:
20.81
4o7gB-4rctA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		4 / 8 LEU A  47
VAL A  32
TYR A 108
LEU A  62
 None
 1.17A 4q0bA-4rctA:
undetectable		 4q0bA-4rctA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4rct RESTRICTION
ENDONUCLEASE
R.NGOVII
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 297
ASP A 268
SER A 179
LEU A 318
THR A 317
 None
 1.30A 5tiwB-4rctA:
undetectable		 5tiwB-4rctA:
20.92