SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
5 / 12 ARG A 383
ASN A 385
ILE A 387
ASP A 431
LEU A 428
None
1.08A 1r9oA-4rcwA:
undetectable
1r9oA-4rcwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
5 / 11 LEU A 476
LEU A 452
VAL A 490
GLY A 465
ARG A 440
None
1.50A 1y4lB-4rcwA:
undetectable
1y4lB-4rcwA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
4 / 5 LEU A 552
ILE A 524
LEU A 501
SER A 500
None
0.98A 2byoA-4rcwA:
undetectable
2byoA-4rcwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
5 / 12 LEU A 428
PHE A 419
LEU A 449
ILE A 411
VAL A 494
None
1.22A 2pnjB-4rcwA:
undetectable
2pnjB-4rcwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
5 / 11 LEU A 478
LEU A 501
LEU A 526
ILE A 462
VAL A 514
None
1.32A 2qd3A-4rcwA:
undetectable
2qd3A-4rcwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
4 / 8 ILE A 350
GLY A 354
LEU A 401
PHE A 381
None
0.86A 2vctB-4rcwA:
undetectable
2vctB-4rcwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
4 / 7 ILE A 350
GLY A 354
LEU A 401
PHE A 381
None
0.89A 2vctD-4rcwA:
undetectable
2vctD-4rcwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
5 / 10 LEU A 435
ILE A 390
LEU A 406
PHE A 419
THR A 466
None
1.20A 3jw5B-4rcwA:
undetectable
3jw5B-4rcwA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo
sapiens)
4 / 8 PHE A 419
LEU A 446
ASN A 416
VAL A 414
None
0.82A 5nujA-4rcwA:
undetectable
5nujA-4rcwA:
17.37