SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 HIS A 199
ASN A  43
ILE A 207
ASP A 205
 None
 1.03A 2v57A-4rd8A:
undetectable		 2v57A-4rd8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 HIS A 199
ASN A  43
ILE A 207
ASP A 205
 None
 1.03A 2v57C-4rd8A:
undetectable		 2v57C-4rd8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 9 LEU A  99
ILE A 131
ILE A 182
MET A  90
MET A 105
 None
 1.26A 3zosB-4rd8A:
undetectable		 3zosB-4rd8A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 11 ILE A  77
LEU A 135
SER A 197
ILE A 200
LEU A 211
 None
 1.08A 4qleB-4rd8A:
undetectable		 4qleB-4rd8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.21A 4tzcB-4rd8A:
undetectable
4tzcD-4rd8A:
undetectable		 4tzcB-4rd8A:
16.30
4tzcD-4rd8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.23A 4tzuB-4rd8A:
undetectable
4tzuC-4rd8A:
undetectable		 4tzuB-4rd8A:
19.21
4tzuC-4rd8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.23A 4tzuB-4rd8A:
undetectable
4tzuC-4rd8A:
undetectable		 4tzuB-4rd8A:
19.21
4tzuC-4rd8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 CYH A 134
LEU A 138
LEU A  81
LEU A  76
ALA A 130
 None
 1.25A 4x1kA-4rd8A:
undetectable
4x1kB-4rd8A:
undetectable		 4x1kA-4rd8A:
20.68
4x1kB-4rd8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A  77
LEU A 135
SER A 197
ILE A 200
LEU A 211
 None
 1.03A 5hi6A-4rd8A:
undetectable		 5hi6A-4rd8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 PHE A  25
PRO A  24
THR A  30
ILE A  26
 None
 1.25A 5ih0A-4rd8A:
undetectable		 5ih0A-4rd8A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.22A 5yizG-4rd8A:
undetectable
5yizY-4rd8A:
undetectable		 5yizG-4rd8A:
16.18
5yizY-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.18A 5yizk-4rd8A:
undetectable
5yizt-4rd8A:
undetectable		 5yizk-4rd8A:
16.18
5yizt-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.21A 5yizk-4rd8A:
undetectable
5yizt-4rd8A:
undetectable		 5yizk-4rd8A:
16.18
5yizt-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.17A 5yizG-4rd8A:
undetectable
5yizY-4rd8A:
undetectable		 5yizG-4rd8A:
16.18
5yizY-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.22A 5yj0G-4rd8A:
undetectable
5yj0Y-4rd8A:
undetectable		 5yj0G-4rd8A:
16.18
5yj0Y-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.19A 5yj0k-4rd8A:
undetectable
5yj0t-4rd8A:
undetectable		 5yj0k-4rd8A:
16.18
5yj0t-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.22A 5yj0k-4rd8A:
undetectable
5yj0t-4rd8A:
undetectable		 5yj0k-4rd8A:
16.18
5yj0t-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.18A 5yj0G-4rd8A:
undetectable
5yj0Y-4rd8A:
undetectable		 5yj0G-4rd8A:
16.18
5yj0Y-4rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.22A 5yj1G-4rd8A:
undetectable
5yj1Y-4rd8A:
undetectable		 5yj1G-4rd8A:
19.34
5yj1Y-4rd8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.19A 5yj1k-4rd8A:
undetectable
5yj1t-4rd8A:
undetectable		 5yj1k-4rd8A:
19.34
5yj1t-4rd8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.22A 5yj1k-4rd8A:
undetectable
5yj1t-4rd8A:
undetectable		 5yj1k-4rd8A:
19.34
5yj1t-4rd8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.18A 5yj1G-4rd8A:
undetectable
5yj1Y-4rd8A:
undetectable		 5yj1G-4rd8A:
19.34
5yj1Y-4rd8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 HIS A 124
HIS A 199
LEU A  36
VAL A  42
 None
 1.16A 6bc9A-4rd8A:
undetectable		 6bc9A-4rd8A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4rd8 UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A  73
ILE A 200
HIS A 199
THR A  39
VAL A  42
 None
 1.29A 6djzB-4rd8A:
undetectable		 6djzB-4rd8A:
21.03