SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rdc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 VAL A 169
LEU A 380
GLY A 151
PRO A 152
SER A 332
 None
None
None
None
GOL  A 503 ( 3.9A)
 1.30A 1fdsA-4rdcA:
5.2		 1fdsA-4rdcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 7 SER A 137
GLY A 128
THR A 110
ILE A 126
 None
 0.95A 1gtnF-4rdcA:
undetectable
1gtnG-4rdcA:
undetectable		 1gtnF-4rdcA:
12.15
1gtnG-4rdcA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 10 GLY A 125
PHE A 114
VAL A 123
GLY A  58
VAL A 147
 None
 1.24A 1pwyE-4rdcA:
3.7		 1pwyE-4rdcA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 5 GLY A 158
ILE A 159
VAL A 173
SER A 132
 None
None
None
PRO  A 501 (-2.6A)
 1.16A 1rs7A-4rdcA:
undetectable		 1rs7A-4rdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 10 GLY A 125
PHE A 114
VAL A 123
GLY A  58
VAL A 147
 None
 1.14A 1v3qE-4rdcA:
undetectable		 1v3qE-4rdcA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 7 THR A 103
PRO A 129
SER A 137
LEU A 256
 None
 0.98A 2hdnE-4rdcA:
undetectable
2hdnF-4rdcA:
2.7
2hdnH-4rdcA:
2.9		 2hdnE-4rdcA:
7.94
2hdnF-4rdcA:
21.48
2hdnH-4rdcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 7 SER A 137
LEU A 256
THR A 103
PRO A 129
 None
 0.92A 2hdnF-4rdcA:
2.7
2hdnG-4rdcA:
undetectable
2hdnH-4rdcA:
2.9		 2hdnF-4rdcA:
21.48
2hdnG-4rdcA:
7.94
2hdnH-4rdcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 9 PHE A 316
ALA A 319
TYR A 320
ALA A  76
GLY A  77
 None
None
GOL  A 503 (-4.8A)
GOL  A 503 (-3.5A)
None
 1.32A 2v7bA-4rdcA:
2.8		 2v7bA-4rdcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 9 PHE A 316
ALA A 319
TYR A 320
ALA A  76
GLY A  77
 None
None
GOL  A 503 (-4.8A)
GOL  A 503 (-3.5A)
None
 1.34A 2v7bB-4rdcA:
undetectable		 2v7bB-4rdcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 ASN A 201
ILE A 162
THR A 155
ASN A 139
PHE A 114
 None
None
PRO  A 501 (-3.2A)
None
None
 1.50A 3a25A-4rdcA:
2.6		 3a25A-4rdcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 GLY A 255
ASP A 202
ILE A 252
LEU A 282
THR A 215
 None
PRO  A 501 ( 4.8A)
None
None
None
 1.15A 3eeyC-4rdcA:
4.2		 3eeyC-4rdcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 GLY A 255
ASP A 202
ILE A 252
LEU A 282
THR A 215
 None
PRO  A 501 ( 4.8A)
None
None
None
 1.17A 3eeyE-4rdcA:
undetectable		 3eeyE-4rdcA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 8 ALA A 135
ASN A 154
PHE A 204
ALA A 156
 None
None
PRO  A 501 (-3.4A)
PRO  A 501 ( 4.9A)
 1.03A 3t3sE-4rdcA:
undetectable		 3t3sE-4rdcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 9 LEU A 267
ASP A 296
ILE A 401
ILE A 277
LEU A 263
 None
 0.92A 3u7sA-4rdcA:
undetectable		 3u7sA-4rdcA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 5 GLY A 158
ILE A 159
VAL A 173
SER A 132
 None
None
None
PRO  A 501 (-2.6A)
 1.26A 4d33A-4rdcA:
undetectable		 4d33A-4rdcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 5 GLY A 158
ILE A 159
VAL A 173
SER A 132
 None
None
None
PRO  A 501 (-2.6A)
 1.23A 4d33B-4rdcA:
undetectable		 4d33B-4rdcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 ALA A 167
GLY A 389
ILE A 159
ASN A 154
GLY A 151
 None
MG  A 502 ( 4.4A)
None
None
None
 1.05A 4obwD-4rdcA:
undetectable		 4obwD-4rdcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 VAL A 287
SER A 332
PHE A 331
GLY A 281
ASP A 280
 None
GOL  A 503 ( 3.9A)
PRO  A 501 (-4.3A)
PRO  A 501 ( 4.6A)
PRO  A 501 (-3.7A)
 1.20A 4pevB-4rdcA:
10.5		 4pevB-4rdcA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 8 SER A 205
ALA A 257
LEU A 282
GLY A 279
 None
 0.97A 4xk8a-4rdcA:
undetectable		 4xk8a-4rdcA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 6 LEU A 380
SER A 170
PRO A 172
GLU A 208
 None
 1.27A 5b8iA-4rdcA:
undetectable		 5b8iA-4rdcA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 10 GLY A 279
LEU A 282
GLN A 200
PHE A 229
LEU A  70
 None
 1.31A 5fhzC-4rdcA:
2.1		 5fhzC-4rdcA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 ILE A  59
GLY A  58
VAL A 124
VAL A 147
ALA A  78
 None
 1.18A 5n0oA-4rdcA:
3.6		 5n0oA-4rdcA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		5 / 12 ILE A  59
GLY A  58
VAL A 124
VAL A 147
ALA A  78
 None
 1.15A 5n0rA-4rdcA:
3.5		 5n0rA-4rdcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 4 GLN A 302
GLN A 330
PRO A 328
ALA A 333
 None
 1.42A 5odcA-4rdcA:
7.3
5odcG-4rdcA:
5.2		 5odcA-4rdcA:
19.67
5odcG-4rdcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 5 PRO A 328
ALA A 333
GLN A 302
GLN A 330
 None
 1.41A 5odcA-4rdcA:
7.4
5odcG-4rdcA:
5.2		 5odcA-4rdcA:
19.67
5odcG-4rdcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 5 ALA A  78
VAL A 339
PHE A 100
ILE A  96
 None
 0.98A 5of1A-4rdcA:
undetectable		 5of1A-4rdcA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4rdc AMINO ACID/AMIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, HAAT FAMILY
(Trichormus
variabilis) 		4 / 4 LEU A 282
GLY A 279
SER A 254
SER A 205
 None
 1.39A 5uunA-4rdcA:
1.8		 5uunA-4rdcA:
22.25