SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 5 HIS A  23
HIS A 171
HIS A 200
ASP A 257
 CO  A 401 (-3.3A)
CO  A 402 ( 3.1A)
CO  A 402 (-3.3A)
CO  A 401 ( 2.5A)
 0.80A 1e9yB-4rdyA:
13.6		 1e9yB-4rdyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 12 VAL A 201
GLY A 202
LEU A 222
GLY A 199
VAL A 303
 None
 1.02A 1fduA-4rdyA:
undetectable		 1fduA-4rdyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 12 VAL A 201
GLY A 202
LEU A 222
GLY A 199
VAL A 303
 None
 1.03A 1fduC-4rdyA:
2.0		 1fduC-4rdyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 6 HIS A  23
HIS A  25
HIS A 171
HIS A 200
ASP A 257
 CO  A 401 (-3.3A)
CO  A 401 ( 3.3A)
CO  A 402 ( 3.1A)
CO  A 402 (-3.3A)
CO  A 401 ( 2.5A)
 0.81A 1fweC-4rdyA:
13.6		 1fweC-4rdyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ASP A 122
PHE A 136
VAL A  70
 None
None
KCX  A 138 ( 4.8A)
 0.78A 1kijB-4rdyA:
undetectable		 1kijB-4rdyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ASP A 257
HIS A 200
HIS A  23
 CO  A 401 ( 2.5A)
CO  A 402 (-3.3A)
CO  A 401 (-3.3A)
 0.67A 1oe1A-4rdyA:
undetectable		 1oe1A-4rdyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ASP A 257
HIS A 200
HIS A  23
 CO  A 401 ( 2.5A)
CO  A 402 (-3.3A)
CO  A 401 (-3.3A)
 0.68A 1oe3A-4rdyA:
undetectable		 1oe3A-4rdyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 7 LEU A 182
ILE A 185
ALA A 139
ILE A 103
 None
None
KCX  A 138 ( 3.4A)
None
 0.93A 1oniB-4rdyA:
undetectable
1oniC-4rdyA:
undetectable		 1oniB-4rdyA:
18.04
1oniC-4rdyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 6 ASN A 176
GLN A 212
ILE A 183
PHE A 186
 None
None
GOL  A 407 ( 4.2A)
None
 1.22A 2jn3A-4rdyA:
undetectable		 2jn3A-4rdyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 11 LEU A 311
ILE A 169
PHE A 136
LEU A  68
ASP A  67
 None
None
None
KCX  A 138 ( 4.2A)
None
 1.25A 2qeiA-4rdyA:
undetectable		 2qeiA-4rdyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 8 SER A 172
ILE A 141
ASP A 181
ARG A 184
 None
None
GOL  A 405 (-4.0A)
GOL  A 407 ( 4.3A)
 0.94A 2v57A-4rdyA:
undetectable		 2v57A-4rdyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 8 SER A 172
ILE A 141
ASP A 181
ARG A 184
 None
None
GOL  A 405 (-4.0A)
GOL  A 407 ( 4.3A)
 0.94A 2v57C-4rdyA:
undetectable		 2v57C-4rdyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ASP A 257
HIS A 200
HIS A  23
 CO  A 401 ( 2.5A)
CO  A 402 (-3.3A)
CO  A 401 (-3.3A)
 0.69A 2xxgA-4rdyA:
undetectable		 2xxgA-4rdyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ASP A 257
HIS A 200
HIS A  23
 CO  A 401 ( 2.5A)
CO  A 402 (-3.3A)
CO  A 401 (-3.3A)
 0.69A 2xxgC-4rdyA:
undetectable		 2xxgC-4rdyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 8 GLY A  94
ASP A 122
ILE A 123
VAL A 166
 None
 0.81A 3fi0B-4rdyA:
undetectable		 3fi0B-4rdyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 7 GLY A  94
ASP A 122
ILE A 123
VAL A 166
 None
 0.80A 3fi0E-4rdyA:
undetectable		 3fi0E-4rdyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 8 GLY A  94
ASP A 122
ILE A 123
VAL A 166
 None
 0.79A 3fi0Q-4rdyA:
undetectable		 3fi0Q-4rdyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ILE A 198
PHE A 186
HIS A 171
 None
None
CO  A 402 ( 3.1A)
 0.73A 3h0aA-4rdyA:
undetectable		 3h0aA-4rdyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ARG A 224
HIS A 200
TYR A 230
 3M5  A 403 ( 4.1A)
CO  A 402 (-3.3A)
None
 1.01A 4fu8A-4rdyA:
undetectable		 4fu8A-4rdyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		3 / 3 ARG A 224
HIS A 200
TYR A 230
 3M5  A 403 ( 4.1A)
CO  A 402 (-3.3A)
None
 1.01A 4fu9A-4rdyA:
undetectable		 4fu9A-4rdyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 5 HIS A  23
HIS A 171
HIS A 200
ASP A 257
 CO  A 401 (-3.3A)
CO  A 402 ( 3.1A)
CO  A 402 (-3.3A)
CO  A 401 ( 2.5A)
 0.77A 4h9mA-4rdyA:
5.5		 4h9mA-4rdyA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 4 ALA A 153
ALA A 156
ALA A 157
ALA A 160
 None
None
KCX  A 138 ( 3.7A)
None
 0.13A 4oadA-4rdyA:
undetectable		 4oadA-4rdyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		4 / 4 ALA A 153
ALA A 156
ALA A 157
ALA A 160
 None
None
KCX  A 138 ( 3.7A)
None
 0.10A 4oaeA-4rdyA:
undetectable		 4oaeA-4rdyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 6 HIS A  23
HIS A  25
HIS A 171
HIS A 200
ASP A 257
 CO  A 401 (-3.3A)
CO  A 401 ( 3.3A)
CO  A 402 ( 3.1A)
CO  A 402 (-3.3A)
CO  A 401 ( 2.5A)
 0.66A 4ubpC-4rdyA:
13.3		 4ubpC-4rdyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 12 VAL A 174
SER A 172
PHE A 173
HIS A 256
VAL A 274
 None
 1.19A 5ergB-4rdyA:
undetectable		 5ergB-4rdyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 12 ILE A  73
GLY A  72
ASP A 257
HIS A  25
TYR A 100
 None
None
CO  A 401 ( 2.5A)
CO  A 401 ( 3.3A)
GOL  A 406 (-3.8A)
 1.12A 5igvA-4rdyA:
undetectable		 5igvA-4rdyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4rdy PARATHION HYDROLASE
(Vulcanisaeta
moutnovskia) 		5 / 12 GLY A  72
ASP A 257
HIS A  25
SER A 172
TYR A 100
 None
CO  A 401 ( 2.5A)
CO  A 401 ( 3.3A)
None
GOL  A 406 (-3.8A)
 1.31A 5igwA-4rdyA:
undetectable		 5igwA-4rdyA:
22.41