SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4re2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 11 THR A  26
VAL A 455
GLY A 453
VAL A  33
VAL A  67
 None
 1.15A 1akdA-4re2A:
undetectable		 1akdA-4re2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 ILE A 219
GLY A 242
SER A 309
LEU A 275
LEU A 245
 None
 1.03A 1rjdA-4re2A:
undetectable		 1rjdA-4re2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 ILE A 219
GLY A 242
SER A 309
LEU A 275
LEU A 245
 None
 1.01A 1rjdB-4re2A:
2.1		 1rjdB-4re2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 ILE A 219
GLY A 242
SER A 309
LEU A 275
LEU A 245
 None
 1.05A 1rjdC-4re2A:
undetectable		 1rjdC-4re2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 7 GLY A 354
ILE A 364
VAL A 365
PRO A 366
 None
 1.06A 1rxcF-4re2A:
undetectable		 1rxcF-4re2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 7 GLY A 354
ILE A 364
VAL A 365
PRO A 366
 None
 1.07A 1rxcL-4re2A:
undetectable		 1rxcL-4re2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 9 LEU A 438
ILE A 410
PRO A 466
VAL A 455
ILE A 454
 None
 1.09A 2avoA-4re2A:
undetectable		 2avoA-4re2A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 10 THR A  26
VAL A 455
GLY A 453
VAL A  33
VAL A  67
 None
 1.09A 2cp4A-4re2A:
undetectable		 2cp4A-4re2A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 6 ALA A 357
TYR A 412
TRP A 361
ILE A 364
 None
None
EPE  A 503 ( 3.5A)
None
 1.22A 2dcfA-4re2A:
undetectable		 2dcfA-4re2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 11 LEU A 145
GLY A 204
ALA A 203
ASP A 202
GLY A 191
 None
 0.96A 2fxdA-4re2A:
undetectable		 2fxdA-4re2A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 5 LEU A 136
PRO A 137
LEU A 140
ILE A 152
 None
 0.79A 2qd4A-4re2A:
undetectable		 2qd4A-4re2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 11 ASN A 178
GLU A 179
TYR A 318
GLU A 389
TRP A 436
 MVL  A 501 (-2.9A)
MVL  A 501 (-2.6A)
MVL  A 501 (-3.8A)
MVL  A 501 (-2.8A)
MVL  A 501 (-3.7A)
 0.82A 2v3dB-4re2A:
3.8		 2v3dB-4re2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 6 THR A  26
VAL A 455
VAL A  33
VAL A  67
 None
 0.97A 2z97A-4re2A:
undetectable		 2z97A-4re2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 7 ALA A 357
TYR A 412
TRP A 361
ILE A 364
 None
None
EPE  A 503 ( 3.5A)
None
 1.16A 2zm7A-4re2A:
undetectable		 2zm7A-4re2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 LEU A 477
ARG A  15
GLY A 432
ILE A 315
VAL A 373
 None
 1.20A 2zznA-4re2A:
undetectable		 2zznA-4re2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 11 ILE A 424
LEU A  13
LEU A 420
ILE A 417
PRO A  19
 None
 1.22A 3a50B-4re2A:
undetectable		 3a50B-4re2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 9 LEU A 438
ILE A 410
PRO A 466
VAL A 455
ILE A 454
 None
 1.10A 3d1yB-4re2A:
undetectable		 3d1yB-4re2A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 ILE A 386
LEU A 275
GLU A 389
PRO A 180
ARG A  89
 None
None
MVL  A 501 (-2.8A)
None
None
 1.27A 3eigA-4re2A:
undetectable		 3eigA-4re2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 7 PHE A  18
PHE A  24
TYR A 433
GLY A 314
 None
 1.12A 3em0B-4re2A:
undetectable		 3em0B-4re2A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 5 ALA A 224
ALA A 157
ARG A 228
LYS A 232
 None
 1.45A 3kp2B-4re2A:
undetectable		 3kp2B-4re2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ALA A 224
ARG A 228
LYS A 232
 None
 0.76A 3kp3B-4re2A:
undetectable		 3kp3B-4re2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ALA A 224
ARG A 228
LYS A 232
 None
 0.90A 3kp5B-4re2A:
undetectable		 3kp5B-4re2A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 LEU A 145
GLY A 204
ALA A 203
ASP A 202
GLY A 191
 None
 1.05A 3oxxA-4re2A:
undetectable		 3oxxA-4re2A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 LEU A 145
GLY A 204
ALA A 203
ASP A 202
GLY A 191
 None
 1.06A 3oxxC-4re2A:
undetectable		 3oxxC-4re2A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 GLU A 389
TYR A 134
TYR A 318
TYR A 250
VAL A 248
 MVL  A 501 (-2.8A)
MVL  A 501 (-4.7A)
MVL  A 501 (-3.8A)
None
None
 1.43A 3rlbB-4re2A:
undetectable		 3rlbB-4re2A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 8 TYR A 188
TYR A 132
LEU A 140
TRP A  94
 None
 1.43A 3uzzB-4re2A:
7.9		 3uzzB-4re2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 10 ILE A  46
GLY A 187
TYR A 188
GLU A 210
GLY A 191
 None
 1.25A 4bwlC-4re2A:
10.9		 4bwlC-4re2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 4 LEU A 136
PRO A 137
LEU A 140
ILE A 152
 None
 0.88A 4f4dB-4re2A:
undetectable		 4f4dB-4re2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ASP A 135
TRP A 436
SER A  91
 None
MVL  A 501 (-3.7A)
None
 0.96A 4lrhB-4re2A:
undetectable		 4lrhB-4re2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ASP A 135
TRP A 436
SER A  91
 None
MVL  A 501 (-3.7A)
None
 1.05A 4lrhF-4re2A:
undetectable		 4lrhF-4re2A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 5 TYR A 113
ARG A  96
GLU A  69
VAL A 457
 None
 1.27A 4nkvB-4re2A:
undetectable		 4nkvB-4re2A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 6 GLY A 391
PHE A 473
ILE A 454
PHE A  85
 None
 1.09A 4qogA-4re2A:
undetectable
4qogB-4re2A:
undetectable		 4qogA-4re2A:
18.91
4qogB-4re2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ASN A 178
PHE A 434
TYR A  88
 MVL  A 501 (-2.9A)
None
None
 0.67A 4u15A-4re2A:
undetectable		 4u15A-4re2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 7 ILE A 369
HIS A 317
LEU A 387
GLY A 391
 None
 1.05A 4z69A-4re2A:
undetectable		 4z69A-4re2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 TYR A 134
TYR A  88
SER A 437
 MVL  A 501 (-4.7A)
None
None
 0.73A 5iktB-4re2A:
0.0		 5iktB-4re2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		4 / 5 LEU A 420
TYR A 416
LEU A 387
TYR A 433
 None
 1.49A 5ki6A-4re2A:
undetectable		 5ki6A-4re2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 ARG A 265
ILE A 290
SER A 286
 None
 0.84A 5zw2A-4re2A:
undetectable		 5zw2A-4re2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 12 TYR A 318
ALA A 435
ALA A  27
LEU A 244
ILE A 243
 MVL  A 501 (-3.8A)
None
None
None
None
 1.17A 6aybA-4re2A:
undetectable		 6aybA-4re2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		3 / 3 TYR A 336
ASP A 338
GLN A 337
 None
 0.94A 6g1pA-4re2A:
undetectable		 6g1pA-4re2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE
(Oryza
sativa) 		5 / 10 ASP A  48
SER A  45
SER A 437
ALA A 435
VAL A  33
 None
 1.46A 6hu9L-4re2A:
undetectable
6hu9P-4re2A:
undetectable
6hu9T-4re2A:
undetectable		 6hu9L-4re2A:
23.29
6hu9P-4re2A:
18.47
6hu9T-4re2A:
9.52