SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4red'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
 None
 0.69A 2fumB-4redA:
21.8		 2fumB-4redA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
 None
 0.81A 2fumC-4redA:
21.6		 2fumC-4redA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  24
GLY A  25
GLY A  27
VAL A  32
ALA A  45
MET A  95
 None
 0.50A 2fumD-4redA:
21.6		 2fumD-4redA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 LEU A 209
LEU A 206
ILE A 199
ARG A 258
 None
 1.18A 2hc4A-4redA:
undetectable		 2hc4A-4redA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 6 PRO A 144
ASP A 218
ASP A 217
TYR A 181
 None
 1.31A 2lh8A-4redA:
undetectable		 2lh8A-4redA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 TYR A 131
HIS A  77
PRO A  76
TYR A 277
 None
 1.13A 2ombC-4redA:
undetectable
2ombD-4redA:
undetectable		 2ombC-4redA:
19.72
2ombD-4redA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 113
LEU A 209
LEU A 206
LEU A 149
TYR A 106
 None
 1.49A 2w8yB-4redA:
undetectable		 2w8yB-4redA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 TYR A 238
TYR A 234
LEU A 239
ASN A 240
 None
 1.47A 2w98A-4redA:
undetectable
2w98B-4redA:
undetectable		 2w98A-4redA:
19.59
2w98B-4redA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 LEU A 162
VAL A 137
ARG A 140
 None
 0.86A 3b0wB-4redA:
undetectable		 3b0wB-4redA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 VAL A  32
LEU A  20
VAL A  46
ILE A  15
THR A  87
 None
 1.18A 3frqA-4redA:
undetectable		 3frqA-4redA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  24
GLY A  25
GLY A  27
GLY A  30
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
 None
 0.80A 3fupA-4redA:
16.9		 3fupA-4redA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  25
GLY A  27
VAL A  32
ALA A  45
MET A  95
TYR A  97
 None
 0.55A 3fupB-4redA:
17.1		 3fupB-4redA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
 None
 0.79A 3lxkA-4redA:
16.9		 3lxkA-4redA:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 ILE A  78
ILE A  79
MET A  93
TYR A  97
ILE A 157
 None
 0.65A 3zosA-4redA:
13.8		 3zosA-4redA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 LEU A  24
ILE A  78
MET A  93
TYR A  97
ILE A 157
 None
 0.73A 3zosB-4redA:
13.9		 3zosB-4redA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 5 VAL A  32
ILE A  78
TYR A  97
ILE A 157
 None
 0.67A 4c8bA-4redA:
18.3		 4c8bA-4redA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 11 LEU A 142
ILE A 157
PHE A 279
LEU A 206
ILE A 199
 None
 1.19A 4dm8A-4redA:
undetectable		 4dm8A-4redA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 ARG A 265
GLU A 281
ARG A 134
 None
 0.93A 4mwvA-4redA:
undetectable		 4mwvA-4redA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 None
 0.60A 5lw1B-4redA:
19.2		 5lw1B-4redA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 10 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 None
 0.65A 5lw1E-4redA:
19.1		 5lw1E-4redA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  24
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
 None
 0.48A 5n3hA-4redA:
22.0		 5n3hA-4redA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
ALA A 158
 None
 0.70A 5xv7A-4redA:
18.5		 5xv7A-4redA:
13.65