SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4reg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4reg UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ILE A   9
MET A 245
LEU A 266
GLY A   7
 None
 0.86A 2qqdB-4regA:
0.9
2qqdC-4regA:
undetectable		 2qqdB-4regA:
14.03
2qqdC-4regA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4reg UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 226
GLY A 206
LEU A 202
PHE A  67
 None
 1.00A 2vctD-4regA:
undetectable		 2vctD-4regA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4reg UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ILE A   5
SER A 247
ILE A 243
VAL A 325
VAL A 329
 None
 1.35A 3rf4A-4regA:
undetectable
3rf4B-4regA:
undetectable		 3rf4A-4regA:
14.93
3rf4B-4regA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4reg UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ILE A   5
SER A 247
ILE A 243
VAL A 325
VAL A 329
 None
 1.37A 3rf4B-4regA:
undetectable
3rf4C-4regA:
undetectable		 3rf4B-4regA:
14.93
3rf4C-4regA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4reg UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 PHE A  67
ILE A 243
LEU A 242
LYS A 240
 None
 1.37A 3sueC-4regA:
undetectable		 3sueC-4regA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4reg UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ALA A 116
ASN A  75
LEU A  76
VAL A  74
 None
 1.08A 4g24A-4regA:
undetectable		 4g24A-4regA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4reg UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 6 PRO A  48
ILE A 148
VAL A  44
PHE A 282
ARG A   8
 None
 1.49A 4xe5A-4regA:
undetectable		 4xe5A-4regA:
17.68