SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 GLU A  31
LEU A 230
LEU A  14
GLY A  10
PHE A 243
 FAD  A 501 (-2.7A)
None
None
FAD  A 501 (-3.4A)
None
 1.38A 1d4fA-4repA:
4.1		 1d4fA-4repA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 GLU A  31
LEU A 230
LEU A  14
GLY A  37
PHE A 243
 FAD  A 501 (-2.7A)
None
None
None
None
 1.42A 1d4fA-4repA:
4.1		 1d4fA-4repA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 GLY A 461
GLY A 467
GLY A 468
VAL A 463
GLY A  13
 FAD  A 501 (-3.8A)
FAD  A 501 ( 4.1A)
FAD  A 501 (-3.2A)
None
None
 0.88A 1n2xB-4repA:
3.9		 1n2xB-4repA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 ILE A  84
PHE A  86
ALA A  98
THR A  58
LEU A  56
 None
None
None
None
FAD  A 501 (-4.7A)
 1.21A 1og5B-4repA:
undetectable		 1og5B-4repA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 6 ASN A 167
ASN A 168
ILE A 203
GLY A 202
 None
 0.82A 1oniA-4repA:
undetectable
1oniB-4repA:
undetectable		 1oniA-4repA:
15.43
1oniB-4repA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 6 ASN A 167
ASN A 168
ILE A 203
GLY A 202
 None
 0.85A 1oniD-4repA:
undetectable
1oniF-4repA:
undetectable		 1oniD-4repA:
15.43
1oniF-4repA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 11 ILE A 278
VAL A 247
PRO A 292
ALA A 291
VAL A 289
 None
FAD  A 501 (-4.1A)
None
None
None
 1.10A 1rv7A-4repA:
undetectable
1rv7B-4repA:
undetectable		 1rv7A-4repA:
11.78
1rv7B-4repA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 11 THR A 258
VAL A 272
ASN A 455
GLU A 486
ILE A 453
 None
 1.49A 1t6zA-4repA:
2.5		 1t6zA-4repA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 8 TYR A  88
ARG A 188
THR A 216
ALA A  98
TYR A 192
 None
 1.26A 2a1hA-4repA:
undetectable
2a1hB-4repA:
undetectable		 2a1hA-4repA:
20.04
2a1hB-4repA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 10 TYR A  88
ARG A 188
THR A 216
ALA A  98
TYR A 192
 None
 1.26A 2coiA-4repA:
undetectable
2coiB-4repA:
undetectable		 2coiA-4repA:
23.48
2coiB-4repA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 10 TYR A 192
TYR A  88
ARG A 188
THR A 216
ALA A  98
 None
 1.22A 2coiA-4repA:
undetectable
2coiB-4repA:
undetectable		 2coiA-4repA:
23.48
2coiB-4repA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 11 TYR A  88
ARG A 188
THR A 216
ALA A  98
TYR A 192
 None
 1.25A 2cojA-4repA:
undetectable
2cojB-4repA:
undetectable		 2cojA-4repA:
23.48
2cojB-4repA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 9 TYR A 192
TYR A  88
ARG A 188
THR A 216
ALA A  98
 None
 1.20A 2cojA-4repA:
undetectable
2cojB-4repA:
undetectable		 2cojA-4repA:
23.48
2cojB-4repA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 7 ASN A 168
GLY A 202
THR A 205
SER A 175
 None
 1.23A 2o5yH-4repA:
undetectable
2o5yL-4repA:
undetectable		 2o5yH-4repA:
19.19
2o5yL-4repA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 LEU A 305
PHE A 307
PRO A 346
VAL A 348
ILE A 397
 None
 1.47A 2xpwA-4repA:
1.1		 2xpwA-4repA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 ILE A 250
THR A 262
THR A 251
VAL A 257
ILE A   5
 None
 1.27A 2yzqA-4repA:
undetectable		 2yzqA-4repA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		3 / 3 SER A 229
GLN A 228
PHE A 231
 None
 0.83A 3g4lC-4repA:
undetectable		 3g4lC-4repA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 6 TYR A  25
ASN A 455
LEU A 271
LYS A   1
 None
 1.46A 3lslG-4repA:
undetectable		 3lslG-4repA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 9 PHE A 105
LEU A 182
LEU A 124
THR A 119
ILE A 120
 None
 1.09A 3tbgD-4repA:
undetectable		 3tbgD-4repA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 PHE A 241
LEU A  18
GLY A  10
GLY A  13
VAL A   6
 None
None
FAD  A 501 (-3.4A)
None
None
 0.96A 4a6eA-4repA:
3.2		 4a6eA-4repA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 VAL A 257
MET A 286
ILE A 250
GLU A 486
 None
 0.95A 4a97D-4repA:
undetectable		 4a97D-4repA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 VAL A 257
MET A 286
ILE A 250
GLU A 486
 None
 1.07A 4a97G-4repA:
undetectable		 4a97G-4repA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 VAL A 257
MET A 286
ILE A 250
GLU A 486
 None
 1.05A 4a97I-4repA:
undetectable		 4a97I-4repA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 LEU A 305
PHE A 307
PRO A 346
VAL A 348
ILE A 397
 None
 1.44A 4b3aA-4repA:
1.2		 4b3aA-4repA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 9 ALA A  36
PHE A 243
VAL A  27
GLY A  13
VAL A 239
 None
 1.20A 4r20B-4repA:
undetectable		 4r20B-4repA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 GLY A  13
GLY A  12
PHE A 231
GLY A  37
ASN A  33
 None
FAD  A 501 (-3.4A)
None
None
FAD  A 501 (-3.7A)
 0.94A 4rtmA-4repA:
2.6		 4rtmA-4repA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 GLY A 460
GLY A 461
ALA A 434
GLN A 298
ASP A 277
 FAD  A 501 ( 3.7A)
FAD  A 501 (-3.8A)
None
None
None
 1.16A 4ubeA-4repA:
3.6		 4ubeA-4repA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 5 GLY A 376
ARG A 428
GLY A 429
GLU A 421
 None
 0.98A 4z2eB-4repA:
undetectable
4z2eC-4repA:
undetectable		 4z2eB-4repA:
22.28
4z2eC-4repA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 GLY A  10
GLY A  13
GLU A  31
ILE A  29
GLN A 228
 FAD  A 501 (-3.4A)
None
FAD  A 501 (-2.7A)
None
None
 1.25A 4zvmA-4repA:
3.6
4zvmB-4repA:
3.6		 4zvmA-4repA:
18.44
4zvmB-4repA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 11 GLN A 228
GLY A  10
GLY A  13
GLU A  31
ILE A  29
 None
FAD  A 501 (-3.4A)
None
FAD  A 501 (-2.7A)
None
 1.28A 4zvmA-4repA:
3.6
4zvmB-4repA:
3.6		 4zvmA-4repA:
18.44
4zvmB-4repA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 GLY A 460
ILE A 226
SER A 227
GLY A  10
 FAD  A 501 ( 3.7A)
None
None
FAD  A 501 (-3.4A)
 0.86A 5alcL-4repA:
undetectable		 5alcL-4repA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 5 SER A 195
ARG A 428
GLY A 429
GLU A 421
 None
 0.92A 5btiA-4repA:
1.0
5btiB-4repA:
undetectable		 5btiA-4repA:
19.29
5btiB-4repA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 5 SER A 436
ARG A 428
GLY A 429
GLU A 421
 None
 1.16A 5btiA-4repA:
1.0
5btiB-4repA:
undetectable		 5btiA-4repA:
19.29
5btiB-4repA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 5 SER A 195
ARG A 428
GLY A 429
GLU A 421
 None
 0.96A 5btiC-4repA:
undetectable
5btiD-4repA:
undetectable		 5btiC-4repA:
19.29
5btiD-4repA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 GLY A  37
GLU A  64
ALA A  17
ILE A 469
PHE A  57
 None
None
None
FAD  A 501 (-4.2A)
None
 1.25A 5ih0A-4repA:
undetectable		 5ih0A-4repA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 10 ILE A 311
ILE A 409
ILE A 394
ILE A 397
ILE A 393
 None
 0.95A 5murE-4repA:
undetectable		 5murE-4repA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 TRP A 309
THR A 410
ARG A 313
TRP A 368
 None
GOL  A 502 ( 4.1A)
None
None
 1.42A 5tzoA-4repA:
undetectable		 5tzoA-4repA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 TRP A 309
THR A 410
ARG A 313
TRP A 368
 None
GOL  A 502 ( 4.1A)
None
None
 1.42A 5tzoB-4repA:
undetectable		 5tzoB-4repA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 TRP A 309
THR A 410
ARG A 313
TRP A 368
 None
GOL  A 502 ( 4.1A)
None
None
 1.41A 5tzoC-4repA:
undetectable		 5tzoC-4repA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 HIS A 321
ASN A 351
TYR A 349
PHE A 369
 None
 1.26A 5v4vA-4repA:
undetectable		 5v4vA-4repA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 8 HIS A 321
ASN A 351
TYR A 349
PHE A 369
 None
 1.25A 5v4vB-4repA:
undetectable		 5v4vB-4repA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		4 / 5 HIS A 446
ASN A 275
VAL A 273
LEU A 456
 None
FAD  A 501 (-3.1A)
None
None
 1.42A 5xdhD-4repA:
undetectable		 5xdhD-4repA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 ALA A 190
THR A 205
GLY A 202
ASN A 171
PHE A 333
 None
 1.09A 5ybbA-4repA:
undetectable		 5ybbA-4repA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 ILE A  75
ALA A 234
LEU A  66
PHE A  67
ILE A 226
 None
 1.24A 5z6fA-4repA:
undetectable		 5z6fA-4repA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4rep GAMMA-CAROTENE
DESATURASE
(Nonlabens
dokdonensis) 		5 / 12 ILE A   7
GLY A   8
GLY A  10
ALA A  15
VAL A 247
 None
FAD  A 501 (-3.3A)
FAD  A 501 (-3.4A)
None
FAD  A 501 (-4.1A)
 0.93A 6iftA-4repA:
3.5		 6iftA-4repA:
23.44