SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-2
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 CYH B 225
PRO B 227
LEU B 229
ARG G 171
 None
 1.31A 1oafA-4rerB:
undetectable		 1oafA-4rerB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 7 ILE G 312
GLY G 311
PRO G 229
ASN G 203
 AMP  G 403 (-3.6A)
None
None
None
 0.88A 1oniG-4rerG:
undetectable
1oniI-4rerG:
undetectable		 1oniG-4rerG:
18.09
1oniI-4rerG:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-2
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 9 SER G 160
TYR B 259
VAL B 264
ASP G 157
ILE G 156
 None
 1.37A 1qftA-4rerG:
0.0		 1qftA-4rerG:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-2
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 9 SER G 160
TYR B 259
VAL B 264
ASP G 157
ILE G 156
 None
 1.38A 1qftB-4rerG:
0.0		 1qftB-4rerG:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 4 SER G  54
ILE G 114
VAL G  83
THR G 163
 None
 1.19A 1u70A-4rerG:
undetectable		 1u70A-4rerG:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 SER G 137
HIS G 169
ASP G 317
 None
None
AMP  G 403 (-2.9A)
 0.85A 2oxtA-4rerG:
undetectable		 2oxtA-4rerG:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 8 PHE G  61
PHE G  51
ARG G 152
ALA G  63
 None
None
AMP  G 401 (-3.7A)
None
 1.12A 2v7uA-4rerG:
undetectable		 2v7uA-4rerG:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 11 LEU G 249
ASN G 257
VAL G 260
TYR G 214
LEU G  95
 None
 1.21A 3bgrA-4rerG:
undetectable
3bgrB-4rerG:
undetectable		 3bgrA-4rerG:
19.26
3bgrB-4rerG:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ILE G 312
ASP G 317
THR G 200
SER G 226
PRO G 229
 AMP  G 403 (-3.6A)
AMP  G 403 (-2.9A)
AMP  G 403 (-3.5A)
AMP  G 403 (-2.3A)
None
 1.03A 3kpbC-4rerG:
10.5		 3kpbC-4rerG:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 11 ILE G 312
ASP G 317
THR G 200
SER G 226
PRO G 229
 AMP  G 403 (-3.6A)
AMP  G 403 (-2.9A)
AMP  G 403 (-3.5A)
AMP  G 403 (-2.3A)
None
 0.72A 3kpcA-4rerG:
11.2		 3kpcA-4rerG:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ILE G 312
ASP G 317
THR G 200
SER G 226
PRO G 229
 AMP  G 403 (-3.6A)
AMP  G 403 (-2.9A)
AMP  G 403 (-3.5A)
AMP  G 403 (-2.3A)
None
 0.69A 3kpdB-4rerG:
10.8		 3kpdB-4rerG:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 ILE G 312
ASP G 317
THR G 200
SER G 226
PRO G 229
 AMP  G 403 (-3.6A)
AMP  G 403 (-2.9A)
AMP  G 403 (-3.5A)
AMP  G 403 (-2.3A)
None
 0.96A 3kpdC-4rerG:
10.9		 3kpdC-4rerG:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 HIS G 151
HIS G 169
HIS G 298
ASP G 317
ILE G 146
 AMP  G 401 ( 3.4A)
None
AMP  G 403 ( 3.9A)
AMP  G 403 (-2.9A)
None
 1.31A 3njzA-4rerG:
undetectable		 3njzA-4rerG:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 6 HIS G 151
HIS G 169
ARG G 299
HIS G 298
 AMP  G 401 ( 3.4A)
None
AMP  G 402 (-3.9A)
AMP  G 403 ( 3.9A)
 1.24A 3nvcA-4rerG:
undetectable		 3nvcA-4rerG:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		4 / 5 LEU G 153
LEU G 167
LEU G 138
SER G 137
 None
 0.87A 3vhuA-4rerG:
undetectable		 3vhuA-4rerG:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 GLY G 218
VAL G 260
TYR G 241
ASN G 248
LEU G  95
 None
 1.49A 4a83A-4rerG:
undetectable		 4a83A-4rerG:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		5 / 12 TYR G 121
LEU G  86
ALA G  71
ARG G 224
ILE G  88
 AMP  G 401 (-4.5A)
None
None
None
None
 1.15A 4krhB-4rerG:
undetectable		 4krhB-4rerG:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens) 		3 / 3 HIS G 151
HIS G 298
ARG G 299
 AMP  G 401 ( 3.4A)
AMP  G 403 ( 3.9A)
AMP  G 402 (-3.9A)
 1.05A 6b58A-4rerG:
undetectable		 6b58A-4rerG:
18.32