SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		3 / 3 ARG A 141
ILE A 102
TRP A 112
 None
 1.13A 1m8eB-4revA:
undetectable		 1m8eB-4revA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		4 / 6 ASP A  40
TYR A  37
PHE A 166
TYR A 171
 None
 1.21A 2w98A-4revA:
undetectable
2w98B-4revA:
undetectable		 2w98A-4revA:
20.17
2w98B-4revA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		3 / 3 ARG A 141
ILE A 102
TRP A 112
 None
 1.12A 3e68A-4revA:
undetectable		 3e68A-4revA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		3 / 3 ARG A 141
ILE A 102
TRP A 112
 None
 1.13A 3e6tB-4revA:
undetectable		 3e6tB-4revA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		5 / 10 ILE A  83
PHE A  36
ILE A 128
LEU A  34
SER A 121
 None
 1.29A 3qgzA-4revA:
undetectable		 3qgzA-4revA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		5 / 12 ASP A 164
ARG A 141
PHE A  38
ALA A 131
ALA A 159
 None
 1.34A 3ua1A-4revA:
undetectable		 3ua1A-4revA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		5 / 10 ILE A 143
VAL A 145
PHE A 115
ILE A  83
THR A 146
 None
GOL  A 201 (-3.9A)
None
None
None
 1.36A 3um5A-4revA:
undetectable		 3um5A-4revA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		5 / 10 ILE A 143
VAL A 145
PHE A 115
ILE A  83
THR A 146
 None
GOL  A 201 (-3.9A)
None
None
None
 1.37A 3um5B-4revA:
undetectable		 3um5B-4revA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		4 / 5 PHE A  36
THR A 116
PHE A 130
ILE A  83
 None
 1.12A 4jx1E-4revA:
undetectable		 4jx1E-4revA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		4 / 8 PHE A 117
LEU A 119
ILE A 178
VAL A 176
 None
 0.81A 5nujA-4revA:
2.3		 5nujA-4revA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		5 / 12 VAL A 145
PHE A 115
PHE A  38
ILE A  83
PHE A 117
 GOL  A 201 (-3.9A)
None
None
None
None
 1.36A 6ap6A-4revA:
undetectable		 6ap6A-4revA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4rev DISEASE RESISTANCE
RESPONSE PROTEIN 206
(Pisum
sativum) 		5 / 12 VAL A 145
PHE A 115
PHE A  38
ILE A  83
PHE A 117
 GOL  A 201 (-3.9A)
None
None
None
None
 1.35A 6ap6B-4revA:
undetectable		 6ap6B-4revA:
19.57