SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
VAL A  98
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.61A 1fmoE-4rewA:
31.4		 1fmoE-4rewA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 THR A 174
GLY A 189
LEU A 191
TYR A 192
 None
 0.83A 1gtiA-4rewA:
undetectable		 1gtiA-4rewA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 THR A 174
GLY A 189
LEU A 191
TYR A 192
 None
 1.04A 1gtiD-4rewA:
undetectable		 1gtiD-4rewA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 ASN A 146
HIS A 139
PHE A 160
ILE A 125
 STU  A 601 (-4.2A)
None
None
None
 1.43A 1tdnA-4rewA:
undetectable		 1tdnA-4rewA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 LEU A  70
PHE A 160
ARG A 134
 None
 0.83A 1xdkF-4rewA:
undetectable		 1xdkF-4rewA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 ALA A  45
GLY A 101
ASP A 105
LEU A 148
ASP A 159
PHE A 160
 STU  A 601 (-3.2A)
STU  A 601 ( 3.8A)
None
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
None
 1.19A 1xkkA-4rewA:
23.1		 1xkkA-4rewA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 LYS A  47
ASP A 141
CYH A 176
 STU  A 601 ( 3.7A)
None
None
 1.27A 2br4F-4rewA:
undetectable		 2br4F-4rewA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 214
ILE A 205
SER A 201
ALA A 208
ASP A 217
 None
 1.15A 2ejtA-4rewA:
undetectable		 2ejtA-4rewA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 VAL A  32
LYS A  47
VAL A  98
ASN A 146
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.65A 2eufB-4rewA:
28.3		 2eufB-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 11 GLY A  25
GLY A  27
VAL A  32
ALA A  45
MET A  95
TYR A  97
LEU A 148
 STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.72A 2evaA-4rewA:
23.8		 2evaA-4rewA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
VAL A  98
ASP A 141
LYS A 143
ASN A 146
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.1A)
None
None
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.90A 2fumA-4rewA:
29.2		 2fumA-4rewA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		10 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
LYS A 143
ASN A 146
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
None
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.81A 2fumB-4rewA:
29.0		 2fumB-4rewA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
ASN A 146
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
 0.74A 2fumC-4rewA:
26.6		 2fumC-4rewA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
MET A  95
LYS A 143
ASN A 146
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.2A)
 0.61A 2fumD-4rewA:
26.8		 2fumD-4rewA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 LEU A 209
LEU A 206
ILE A 199
ARG A 258
 None
 1.11A 2hc4A-4rewA:
undetectable		 2hc4A-4rewA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 GLN A 124
LYS A 156
VAL A 147
 None
 0.81A 2jfaB-4rewA:
undetectable		 2jfaB-4rewA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 SER A 404
ARG A 403
GLN A 405
 None
 0.94A 2xnrA-4rewA:
undetectable		 2xnrA-4rewA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 10 VAL A  32
ALA A  45
ILE A  79
GLY A 101
ASP A 105
LEU A 148
 STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
STU  A 601 ( 3.8A)
None
STU  A 601 (-4.2A)
 0.90A 2y7jC-4rewA:
31.3		 2y7jC-4rewA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 6 LEU A  24
VAL A  32
LYS A  47
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.2A)
 0.60A 3cs9D-4rewA:
21.6		 3cs9D-4rewA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		9 / 12 GLY A  25
GLY A  27
GLY A  30
ALA A  45
LYS A  47
MET A  95
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
None
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.85A 3eygA-4rewA:
25.6		 3eygA-4rewA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		10 / 12 LEU A  24
GLY A  25
GLY A  30
VAL A  32
ALA A  45
LYS A  47
MET A  95
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
None
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.66A 3eygA-4rewA:
25.6		 3eygA-4rewA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		10 / 12 LEU A  24
GLY A  25
GLY A  30
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
None
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.70A 3fupA-4rewA:
26.0		 3fupA-4rewA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.59A 3fupB-4rewA:
25.9		 3fupB-4rewA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 11 LEU A  24
VAL A  32
ALA A  45
TYR A  97
GLY A 101
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
 0.54A 3g0eA-4rewA:
21.3		 3g0eA-4rewA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 11 LEU A  24
VAL A  32
ALA A  45
TYR A  97
GLY A 101
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
 0.53A 3g0fA-4rewA:
22.1		 3g0fA-4rewA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  24
VAL A  32
ALA A  45
TYR A  97
GLY A 101
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
 0.54A 3g0fB-4rewA:
22.4		 3g0fB-4rewA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		10 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.74A 3lxkA-4rewA:
26.3		 3lxkA-4rewA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  25
ALA A  45
LYS A  47
ILE A  79
TYR A  97
VAL A  98
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
 0.52A 3lxnA-4rewA:
26.3		 3lxnA-4rewA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
ILE A  79
TYR A  97
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.53A 3lxnA-4rewA:
26.3		 3lxnA-4rewA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
TYR A  97
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.56A 3lxnA-4rewA:
26.3		 3lxnA-4rewA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 GLY A  25
VAL A  32
ALA A  45
LYS A  47
LEU A  70
ILE A  79
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
None
STU  A 601 ( 4.6A)
 0.87A 3ohtA-4rewA:
18.9		 3ohtA-4rewA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 ILE A  78
ILE A  79
MET A  93
TYR A  97
ILE A 157
 None
STU  A 601 ( 4.6A)
None
STU  A 601 (-4.4A)
None
 0.69A 3zosA-4rewA:
22.1		 3zosA-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 LEU A  24
ILE A  78
MET A  93
TYR A  97
ILE A 157
 STU  A 601 (-3.7A)
None
None
STU  A 601 (-4.4A)
None
 0.63A 3zosB-4rewA:
22.2		 3zosB-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 ALA A  45
ILE A  79
MET A  93
TYR A  97
LEU A 148
ALA A 158
 STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
None
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 0.88A 4bkjA-4rewA:
22.2		 4bkjA-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
ILE A  79
MET A  93
LEU A 148
ALA A 158
 STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
None
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 1.00A 4bkjB-4rewA:
22.3		 4bkjB-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 5 VAL A  32
ILE A  78
TYR A  97
ILE A 157
 STU  A 601 ( 4.8A)
None
STU  A 601 (-4.4A)
None
 0.49A 4c8bA-4rewA:
22.9		 4c8bA-4rewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 ALA A  45
LYS A  47
LEU A  70
ILE A  78
HIS A 139
LEU A 148
ALA A 158
 STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
None
None
None
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 0.93A 4c8bB-4rewA:
23.0		 4c8bB-4rewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  24
GLY A  25
VAL A  32
ALA A  45
TYR A  97
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.58A 4ckjA-4rewA:
26.0		 4ckjA-4rewA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 TYR A 446
ARG A 529
HIS A 533
 None
 1.19A 4fubA-4rewA:
undetectable		 4fubA-4rewA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
MET A  95
GLY A 101
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.99A 4i22A-4rewA:
22.6		 4i22A-4rewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 ALA A  45
ILE A  79
ASP A 105
ASP A 141
LYS A 143
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
None
None
None
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.69A 4i41A-4rewA:
29.5		 4i41A-4rewA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 VAL A  32
ALA A  45
ILE A  79
ASP A 105
ASP A 141
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
None
None
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.53A 4i41A-4rewA:
29.5		 4i41A-4rewA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 GLY A  25
VAL A  32
ALA A  45
LEU A  81
GLY A 101
GLU A 102
LEU A 148
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
None
STU  A 601 ( 3.8A)
STU  A 601 (-4.0A)
STU  A 601 (-4.2A)
 0.65A 4ifgA-4rewA:
25.8		 4ifgA-4rewA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 VAL A 147
ILE A 107
SER A 118
LEU A 121
LEU A 113
 None
 1.40A 4m11C-4rewA:
undetectable		 4m11C-4rewA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 6 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
 0.43A 4o0wA-4rewA:
30.8		 4o0wA-4rewA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 8 GLY A  27
VAL A  32
ALA A  45
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.71A 4ogrA-4rewA:
27.8		 4ogrA-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 7 GLY A  25
ALA A  45
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.73A 4ogrE-4rewA:
26.8		 4ogrE-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 9 GLY A  27
VAL A  32
ALA A  45
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.70A 4ogrI-4rewA:
27.5		 4ogrI-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  24
GLY A  25
GLY A  30
VAL A  32
ALA A  45
LEU A 148
ALA A 158
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
None
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 0.54A 4otiA-4rewA:
25.0		 4otiA-4rewA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 GLY A  25
VAL A  32
ALA A  45
MET A  95
TYR A  97
LEU A 148
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.62A 4qmzA-4rewA:
29.3		 4qmzA-4rewA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 10 ALA A  45
LYS A  47
ILE A  79
VAL A  98
LEU A 148
 STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
 0.86A 4rz7A-4rewA:
26.9		 4rz7A-4rewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  24
VAL A  32
ALA A  45
LYS A  47
GLY A 101
ASN A 146
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.76A 4twpA-4rewA:
25.2		 4twpA-4rewA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
GLY A 101
ASN A 146
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.81A 4twpB-4rewA:
25.5		 4twpB-4rewA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 6 LEU A  24
VAL A  32
LYS A  47
ILE A  78
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
None
 0.50A 4tyjA-4rewA:
23.2		 4tyjA-4rewA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  24
VAL A  32
ILE A  78
TYR A  97
ARG A 140
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
None
STU  A 601 (-4.4A)
None
None
 0.87A 4u0iA-4rewA:
22.1		 4u0iA-4rewA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 9 LEU A  24
VAL A  32
ALA A  45
TYR A  97
GLY A 101
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
 0.77A 4u5jB-4rewA:
24.7		 4u5jB-4rewA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 ARG A 265
ILE A 264
ALA A 259
ILE A 199
SER A 202
 None
 1.19A 4uroC-4rewA:
undetectable		 4uroC-4rewA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 9 LEU A  24
VAL A  32
ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 0.93A 4v01A-4rewA:
22.4		 4v01A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 9 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
ARG A 140
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
 0.95A 4v01A-4rewA:
22.4		 4v01A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 9 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
LEU A 148
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
None
 0.74A 4v01B-4rewA:
22.7		 4v01B-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 8 ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 1.13A 4v04A-4rewA:
22.2		 4v04A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 8 LYS A  47
ILE A  79
TYR A  97
LEU A 148
 STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.48A 4v04A-4rewA:
22.2		 4v04A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 10 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 1.00A 4v04B-4rewA:
22.5		 4v04B-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
ILE A  78
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
 1.08A 4v04B-4rewA:
22.5		 4v04B-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  24
VAL A  32
ALA A  45
LYS A  47
ILE A  79
TYR A  97
GLY A 101
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
 0.83A 5bvwA-4rewA:
22.3		 5bvwA-4rewA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		8 / 12 VAL A  32
ALA A  45
LYS A  47
ILE A  79
TYR A  97
GLY A 101
LEU A 148
ALA A 158
 STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 0.93A 5bvwA-4rewA:
22.3		 5bvwA-4rewA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 11 LEU A 214
PRO A 184
ALA A 182
ILE A 187
GLU A 145
 None
 1.31A 5ewjA-4rewA:
undetectable
5ewjB-4rewA:
undetectable		 5ewjA-4rewA:
21.94
5ewjB-4rewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 214
PRO A 184
ALA A 182
ILE A 187
GLU A 145
 None
 1.32A 5ewjC-4rewA:
undetectable
5ewjD-4rewA:
undetectable		 5ewjC-4rewA:
21.94
5ewjD-4rewA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 VAL A  32
ALA A  45
ILE A  79
TYR A  97
ASP A 105
GLY A 161
 STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
None
 1.20A 5hesA-4rewA:
7.4		 5hesA-4rewA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 GLY A  25
GLY A  27
VAL A  32
ALA A  45
LYS A  47
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.7A)
 0.94A 5hieC-4rewA:
23.8		 5hieC-4rewA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 7 GLY A  25
GLY A  27
PHE A  29
GLY A  30
LEU A  49
 STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
None
None
None
 1.06A 5izjB-4rewA:
30.8		 5izjB-4rewA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 7 GLY A  25
PHE A  29
VAL A  32
LYS A  47
LEU A  49
 STU  A 601 (-3.5A)
None
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
None
 1.13A 5izjA-4rewA:
30.9		 5izjA-4rewA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 7 GLY A  25
VAL A  32
LYS A  47
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.7A)
 0.46A 5j5xA-4rewA:
31.0		 5j5xA-4rewA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		6 / 12 GLY A  25
VAL A  32
ALA A  45
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.72A 5l2iA-4rewA:
8.0		 5l2iA-4rewA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.3A)
 0.62A 5lw1B-4rewA:
24.7		 5lw1B-4rewA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 10 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.3A)
 0.74A 5lw1E-4rewA:
24.6		 5lw1E-4rewA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		7 / 10 LEU A  24
VAL A  32
ALA A  45
MET A  95
TYR A  97
VAL A  98
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
 0.61A 5n3hA-4rewA:
31.2		 5n3hA-4rewA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 5 TYR A 192
VAL A 197
PRO A 255
ALA A 183
 None
 0.89A 5otrA-4rewA:
24.2		 5otrA-4rewA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 8 LEU A  24
VAL A  32
LYS A  47
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.7A)
 0.66A 5y9mX-4rewA:
24.4		 5y9mX-4rewA:
8.33