SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rf3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		3 / 3 THR A 210
PRO A 213
THR A 212
 None
 0.94A 1dscC-4rf3A:
undetectable		 1dscC-4rf3A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
 None
 1.29A 1kiaD-4rf3A:
6.7		 1kiaD-4rf3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
 None
 1.32A 1nbhA-4rf3A:
7.2		 1nbhA-4rf3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
 None
 1.33A 1nbhC-4rf3A:
6.4		 1nbhC-4rf3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
 None
 1.32A 1nbhD-4rf3A:
6.9		 1nbhD-4rf3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
 None
 1.23A 1nbiC-4rf3A:
6.6		 1nbiC-4rf3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
 None
 1.22A 1nbiD-4rf3A:
5.5		 1nbiD-4rf3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 GLY A  14
ARG A  39
ASP A  63
SER A  65
ALA A  91
 None
 0.98A 2br4C-4rf3A:
5.8		 2br4C-4rf3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 ILE A  23
ALA A  22
GLY A  18
ILE A 223
GLY A  14
 None
 0.82A 2qe6A-4rf3A:
6.7		 2qe6A-4rf3A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 ILE A  23
ALA A  22
GLY A  18
ILE A 223
GLY A  14
 None
 0.84A 2qe6B-4rf3A:
6.3		 2qe6B-4rf3A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		3 / 3 MET A 206
GLU A 145
ASN A 114
 None
 0.89A 3a27A-4rf3A:
6.4		 3a27A-4rf3A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 8 ALA A 171
CYH A 174
THR A 122
ILE A 126
 None
 0.94A 3bpxA-4rf3A:
undetectable
3bpxB-4rf3A:
undetectable		 3bpxA-4rf3A:
22.27
3bpxB-4rf3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 ILE A  23
GLY A  20
ALA A  47
PHE A  27
ALA A  91
 None
 0.98A 3jb1A-4rf3A:
3.7		 3jb1A-4rf3A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		3 / 3 ASN A 184
ALA A 238
ARG A 182
 None
 0.76A 3tj7C-4rf3A:
undetectable
3tj7D-4rf3A:
undetectable		 3tj7C-4rf3A:
18.08
3tj7D-4rf3A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 11 ALA A  47
GLY A  14
GLY A  38
ILE A  36
ASN A 114
 None
 0.99A 4dcmA-4rf3A:
5.3		 4dcmA-4rf3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 7 ARG A 123
GLY A 125
ILE A 138
ASN A 140
 None
 0.96A 4g0vA-4rf3A:
2.1		 4g0vA-4rf3A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 7 ILE A 226
LEU A 230
HIS A 187
VAL A 244
 None
 0.70A 4g77A-4rf3A:
undetectable		 4g77A-4rf3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 11 THR A 102
THR A 103
THR A 104
SER A  96
ALA A 155
 None
 1.49A 4qvyV-4rf3A:
undetectable
4qvyb-4rf3A:
undetectable		 4qvyV-4rf3A:
22.26
4qvyb-4rf3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 11 THR A 102
THR A 103
THR A 104
SER A  96
ALA A 155
 None
 1.49A 4qvyH-4rf3A:
0.0
4qvyN-4rf3A:
0.0		 4qvyH-4rf3A:
22.26
4qvyN-4rf3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 ASP A  63
LEU A 110
ILE A  93
GLY A  92
VAL A 163
 None
 1.08A 4y8wA-4rf3A:
undetectable		 4y8wA-4rf3A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 ASP A  63
LEU A 110
ILE A  93
GLY A  92
VAL A 163
 None
 1.07A 4y8wB-4rf3A:
undetectable		 4y8wB-4rf3A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 8 PHE A  81
GLY A  82
THR A  54
PHE A  27
 None
 0.99A 5flcB-4rf3A:
1.8		 5flcB-4rf3A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 8 PHE A  81
GLY A  82
THR A  54
PHE A  27
 None
 0.99A 5flcF-4rf3A:
1.9		 5flcF-4rf3A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 4 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.27A 5n0rA-4rf3A:
undetectable		 5n0rA-4rf3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 4 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.26A 5n0sA-4rf3A:
1.9		 5n0sA-4rf3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 5 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.23A 5n0tA-4rf3A:
2.1		 5n0tA-4rf3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 4 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.28A 5n0wA-4rf3A:
undetectable		 5n0wA-4rf3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 5 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.31A 5n0wB-4rf3A:
2.1		 5n0wB-4rf3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 4 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.29A 5n0xA-4rf3A:
1.7		 5n0xA-4rf3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		4 / 5 SER A 169
ALA A 170
GLN A 127
THR A 122
 None
 1.33A 5n4iA-4rf3A:
undetectable		 5n4iA-4rf3A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 ASN A 221
VAL A  34
VAL A  12
GLY A  20
ILE A  23
 None
 1.01A 5vopA-4rf3A:
undetectable		 5vopA-4rf3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		5 / 12 GLY A 117
ALA A  64
ASN A 140
SER A 167
GLU A 242
 None
 1.20A 6bqgA-4rf3A:
undetectable		 6bqgA-4rf3A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE
(Lactobacillus
kefiri) 		3 / 3 ARG A 128
LEU A 124
PHE A 120
 None
 0.76A 6nknP-4rf3A:
undetectable		 6nknP-4rf3A:
21.13