SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 11 LEU A  35
VAL A  71
GLY A  70
TRP A  55
LEU A  54
 None
None
ARG  A 805 (-3.8A)
None
None
 1.45A 1jkhA-4rf7A:
undetectable
1jkhB-4rf7A:
3.3		 1jkhA-4rf7A:
22.85
1jkhB-4rf7A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 128
VAL A 224
TRP A 225
 ARG  A 806 (-4.3A)
None
None
 0.95A 1qw6A-4rf7A:
undetectable		 1qw6A-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 480
VAL A 576
TRP A 577
 None
 0.90A 1qw6A-4rf7A:
undetectable		 1qw6A-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 128
VAL A 224
TRP A 225
 ARG  A 806 (-4.3A)
None
None
 0.93A 1qwcA-4rf7A:
undetectable		 1qwcA-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 480
VAL A 576
TRP A 577
 None
 0.88A 1qwcA-4rf7A:
undetectable		 1qwcA-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 8 TRP A 225
ASP A 196
LEU A 199
GLY A 195
 None
 0.81A 1rtsA-4rf7A:
undetectable		 1rtsA-4rf7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 11 VAL A 144
TYR A 138
GLU A 228
LEU A 226
ILE A 152
 None
 1.41A 1t6zB-4rf7A:
undetectable		 1t6zB-4rf7A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 128
VAL A 224
TRP A 225
 ARG  A 806 (-4.3A)
None
None
 0.91A 1vagA-4rf7A:
undetectable		 1vagA-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 480
VAL A 576
TRP A 577
 None
 0.88A 1vagA-4rf7A:
undetectable		 1vagA-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 12 ALA A 201
ASP A 196
SER A  60
ILE A  90
TYR A  79
 None
None
ARG  A 805 ( 4.8A)
None
None
 1.31A 1xvaB-4rf7A:
undetectable		 1xvaB-4rf7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 TRP A 560
LEU A 559
LYS A 239
 None
 1.31A 1yajK-4rf7A:
undetectable		 1yajK-4rf7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 128
VAL A 224
TRP A 225
 ARG  A 806 (-4.3A)
None
None
 0.89A 1zviA-4rf7A:
2.2		 1zviA-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 480
VAL A 576
TRP A 577
 None
 0.84A 1zviA-4rf7A:
2.2		 1zviA-4rf7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 12 TYR A 475
ILE A 661
ALA A 646
GLY A 703
PRO A 644
 None
 1.16A 2okcB-4rf7A:
undetectable		 2okcB-4rf7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 6 VAL A  69
GLU A 229
CYH A 275
SER A 277
 ARG  A 805 (-3.6A)
ARG  A 805 (-2.9A)
ARG  A 805 (-3.4A)
ARG  A 805 ( 3.7A)
 0.46A 3b6rB-4rf7A:
29.7		 3b6rB-4rf7A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 5 ILE A  90
HIS A  94
TYR A  79
GLY A 280
 None
 1.21A 3b9mA-4rf7A:
1.2		 3b9mA-4rf7A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 10 ASP A 548
GLY A 413
GLY A 422
PRO A 494
VAL A 556
 None
None
ACT  A 802 (-4.0A)
None
None
 0.95A 3em4V-4rf7A:
undetectable		 3em4V-4rf7A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 12 LEU A 261
GLY A 262
GLN A 264
PHE A 263
LEU A 226
 None
 1.04A 3gwvA-4rf7A:
undetectable		 3gwvA-4rf7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 12 HIS A 216
LEU A 160
ILE A 235
ILE A 234
LEU A 185
 None
 1.26A 3gwxA-4rf7A:
undetectable		 3gwxA-4rf7A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 7 VAL A 112
MET A 283
ILE A 129
ILE A 243
 None
 0.92A 3hgxA-4rf7A:
undetectable		 3hgxA-4rf7A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 7 VAL A 464
MET A 635
ILE A 481
ILE A 595
 None
 0.92A 3hgxA-4rf7A:
undetectable		 3hgxA-4rf7A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 THR A 497
ASP A 116
GLU A 238
 None
 0.84A 3qowA-4rf7A:
undetectable		 3qowA-4rf7A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 12 SER A 274
GLY A 143
GLY A 203
ALA A 202
GLY A  74
 None
 1.13A 3tegA-4rf7A:
2.1		 3tegA-4rf7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 6 ARG A 501
ASP A 408
GLU A 429
LEU A 496
 None
 1.26A 4ax8A-4rf7A:
undetectable		 4ax8A-4rf7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 GLU A 341
ASP A 106
ASP A 258
 None
 0.79A 4gc9A-4rf7A:
undetectable		 4gc9A-4rf7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 8 LEU A 613
VAL A 487
VAL A 576
ILE A 578
 None
 0.91A 4l4cB-4rf7A:
undetectable		 4l4cB-4rf7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 5 PRO A 525
GLY A 528
ASP A 540
ASP A 530
 None
 1.07A 4n48B-4rf7A:
undetectable		 4n48B-4rf7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 6 ASN A 685
LEU A 602
MET A 700
VAL A 464
 None
 1.11A 4okbA-4rf7A:
undetectable		 4okbA-4rf7A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 4 ASN A 278
SER A 134
ALA A 132
VAL A 131
 ARG  A 805 ( 4.6A)
None
None
None
 1.29A 4x1kC-4rf7A:
undetectable		 4x1kC-4rf7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 11 ASP A 230
ALA A 132
ASP A  75
TYR A  79
GLY A 143
 None
 1.22A 4xp4A-4rf7A:
undetectable		 4xp4A-4rf7A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 VAL A 556
PHE A 544
ARG A 585
 None
 0.92A 4xr4B-4rf7A:
undetectable		 4xr4B-4rf7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 6 TYR A  93
TYR A  79
GLY A  70
ASP A  66
 None
None
ARG  A 805 (-3.8A)
None
 1.13A 5emlA-4rf7A:
undetectable		 5emlA-4rf7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 128
VAL A 224
TRP A 225
 ARG  A 806 (-4.3A)
None
None
 0.91A 5fvoA-4rf7A:
undetectable		 5fvoA-4rf7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		3 / 3 ARG A 480
VAL A 576
TRP A 577
 None
 0.86A 5fvoA-4rf7A:
undetectable		 5fvoA-4rf7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 6 VAL A 112
LYS A 113
ALA A 114
VAL A 345
 None
 1.02A 5i8fA-4rf7A:
undetectable		 5i8fA-4rf7A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		4 / 4 ASN A 278
SER A 134
ALA A 132
VAL A 131
 ARG  A 805 ( 4.6A)
None
None
None
 1.24A 5nm5A-4rf7A:
undetectable		 5nm5A-4rf7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 9 VAL A 641
LEU A 707
ALA A 646
PHE A 652
ILE A 683
 None
 1.21A 5om2A-4rf7A:
undetectable
5om2B-4rf7A:
undetectable		 5om2A-4rf7A:
7.67
5om2B-4rf7A:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4rf7 ARGININE KINASE
(Anthopleura
japonica) 		5 / 12 GLY A 555
GLY A 426
GLY A 495
ALA A 425
TYR A 431
 None
 1.20A 5x7fA-4rf7A:
undetectable		 5x7fA-4rf7A:
16.43