SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_A_5FWA601_1 (BETA-1 ADRENERGIC RECEPTOR)	4rfe	FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4 (Macaca mulatta)	5 / 12	VAL H 163 VAL H 182 SER H 180 ASN H 197 ASN H 155	None	1.45A	2y03A-4rfeH: undetectable	2y03A-4rfeH: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LDO_A_ALEA1402_1 (LYSOZYME, BETA-2 ADRENERGIC RECEPTOR)	4rfe	FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4 (Macaca mulatta)	5 / 10	VAL H 163 VAL H 182 SER H 180 ASN H 197 ASN H 155	None	1.49A	4ldoA-4rfeH: undetectable	4ldoA-4rfeH: 18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AOX_C_ACTC1001_0 (ALU JO CONSENSUS RNA SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN)	4rfe	FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4 (Macaca mulatta)	3 / 3	TYR H 98 THR H 100 THR H 100	None	0.61A	5aoxB-4rfeH: undetectable	5aoxB-4rfeH: 15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AOX_F_ACTF1001_0 (ALU JO CONSENSUS RNA SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN)	4rfe	FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4 (Macaca mulatta)	3 / 3	TYR H 98 THR H 100 THR H 100	None	0.57A	5aoxE-4rfeH: undetectable	5aoxE-4rfeH: 15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7M_B_68HB405_0 (BETA-1 ADRENERGIC RECEPTOR)	4rfe	FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4 (Macaca mulatta)	5 / 12	VAL H 163 VAL H 182 SER H 180 ASN H 197 ASN H 155	None	1.44A	6h7mB-4rfeH: undetectable	6h7mB-4rfeH: 18.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Y03_A_5FWA601_1","BETA-1 ADRENERGIC RECEPTOR","4rfe","FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4","Macaca mulatta",5,"VAL H 163;VAL H 182;SER H 180;ASN H 197;ASN H 155","None","1.45A","2y03A-4rfeH:undetectable","2y03A-4rfeH:22.09"],["4LDO_A_ALEA1402_1","LYSOZYME, BETA-2 ADRENERGIC RECEPTOR","4rfe","FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4","Macaca mulatta",5,"VAL H 163;VAL H 182;SER H 180;ASN H 197;ASN H 155","None","1.49A","4ldoA-4rfeH:undetectable","4ldoA-4rfeH:18.78"],["5AOX_C_ACTC1001_0","ALU JO CONSENSUS RNA;SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN","4rfe","FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4","Macaca mulatta",3,"TYR H  98;THR H 100;THR H 100","None","0.61A","5aoxB-4rfeH:undetectable","5aoxB-4rfeH:15.25"],["5AOX_F_ACTF1001_0","ALU JO CONSENSUS RNA;SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN","4rfe","FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4","Macaca mulatta",3,"TYR H  98;THR H 100;THR H 100","None","0.57A","5aoxE-4rfeH:undetectable","5aoxE-4rfeH:15.25"],["6H7M_B_68HB405_0","BETA-1 ADRENERGIC RECEPTOR","4rfe","FAB HEAVY CHAIN OF ADCC-POTENT ANTI-HIV-1 ANTIBODY JR4","Macaca mulatta",5,"VAL H 163;VAL H 182;SER H 180;ASN H 197;ASN H 155","None","1.44A","6h7mB-4rfeH:undetectable","6h7mB-4rfeH:18.50"]]