SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 ASP A 193
LEU A 194
GLY A 195
GLY A 197
LEU A 201
None
None
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
None
0.33A 2nxeB-4rfqA:
15.2
2nxeB-4rfqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 ASP A 193
LEU A 194
GLY A 195
LEU A 201
ASP A 217
None
None
SAM  A 401 (-3.0A)
None
SAM  A 401 (-3.0A)
0.50A 3cjtC-4rfqA:
15.1
3cjtC-4rfqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 ASP A 193
LEU A 194
GLY A 195
LEU A 201
LEU A 305
None
None
SAM  A 401 (-3.0A)
None
None
1.03A 3cjtC-4rfqA:
15.1
3cjtC-4rfqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
3 / 3 PHE A 206
CYH A 263
PHE A 215
None
1.15A 3cr5X-4rfqA:
undetectable
3cr5X-4rfqA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
3 / 3 PHE A 206
CYH A 263
PHE A 265
None
1.06A 3cr5X-4rfqA:
undetectable
3cr5X-4rfqA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 LEU A 321
THR A 295
LEU A 201
GLY A 195
PHE A 309
None
SAM  A 401 (-4.6A)
None
SAM  A 401 (-3.0A)
None
1.37A 3g1uC-4rfqA:
5.8
3g1uC-4rfqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 LEU A 321
THR A 295
LEU A 201
GLY A 195
PHE A 309
None
SAM  A 401 (-4.6A)
None
SAM  A 401 (-3.0A)
None
1.30A 3glqA-4rfqA:
2.9
3glqA-4rfqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 LEU A 321
THR A 295
LEU A 201
GLY A 195
PHE A 309
None
SAM  A 401 (-4.6A)
None
SAM  A 401 (-3.0A)
None
1.31A 3glqB-4rfqA:
5.9
3glqB-4rfqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 LEU A 321
THR A 295
LEU A 201
GLY A 195
PHE A 309
None
SAM  A 401 (-4.6A)
None
SAM  A 401 (-3.0A)
None
1.25A 3n58A-4rfqA:
5.8
3n58A-4rfqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 9 HIS A 126
LEU A 121
THR A 172
LEU A 201
SER A 198
None
None
SAM  A 401 (-3.7A)
None
None
1.35A 3q1eB-4rfqA:
undetectable
3q1eD-4rfqA:
undetectable
3q1eB-4rfqA:
19.23
3q1eD-4rfqA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 4 GLY A 199
GLY A 202
THR A 204
LEU A 176
None
0.89A 3si7C-4rfqA:
1.8
3si7D-4rfqA:
undetectable
3si7C-4rfqA:
26.36
3si7D-4rfqA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 6 THR A 204
GLY A 202
ARG A 318
LEU A 200
None
1.09A 4ac9C-4rfqA:
undetectable
4ac9C-4rfqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 6 THR A 204
GLY A 202
ARG A 318
LEU A 200
None
1.11A 4acaC-4rfqA:
2.6
4acaC-4rfqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 TRP A 169
GLY A 195
GLY A 197
ASP A 217
GLU A 269
SAM  A 401 (-3.5A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.0A)
1.09A 4lg1A-4rfqA:
17.8
4lg1A-4rfqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 TRP A 169
GLY A 195
GLY A 197
ASP A 217
TYR A 297
SAM  A 401 (-3.5A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
SAM  A 401 (-3.0A)
None
0.73A 4lg1A-4rfqA:
17.8
4lg1A-4rfqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 TRP A 169
GLY A 195
GLY A 197
TRP A 270
TYR A 297
SAM  A 401 (-3.5A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
SAM  A 401 (-3.2A)
None
0.68A 4lg1A-4rfqA:
17.8
4lg1A-4rfqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 TRP A 169
GLY A 195
GLY A 197
TRP A 270
GLU A 269
SAM  A 401 (-3.5A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
SAM  A 401 (-3.2A)
SAM  A 401 (-4.0A)
1.12A 4lg1B-4rfqA:
17.8
4lg1B-4rfqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 TRP A 169
GLY A 195
GLY A 197
TRP A 270
TYR A 297
SAM  A 401 (-3.5A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
SAM  A 401 (-3.2A)
None
0.71A 4lg1B-4rfqA:
17.8
4lg1B-4rfqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 TRP A 169
GLY A 195
GLY A 197
ASP A 217
TYR A 297
SAM  A 401 (-3.5A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
SAM  A 401 (-3.0A)
None
0.82A 4lg1C-4rfqA:
17.3
4lg1C-4rfqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 TRP A 169
GLY A 195
GLY A 197
TRP A 270
TYR A 297
SAM  A 401 (-3.5A)
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
SAM  A 401 (-3.2A)
None
0.76A 4lg1C-4rfqA:
17.3
4lg1C-4rfqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 7 TYR A 297
ASN A  87
GLU A  89
TYR A 218
None
None
SAM  A 401 (-3.3A)
None
1.28A 4mi4A-4rfqA:
3.1
4mi4C-4rfqA:
3.2
4mi4A-4rfqA:
20.00
4mi4C-4rfqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 THR A 172
THR A 295
LEU A 175
ASP A 193
LEU A 201
SAM  A 401 (-3.7A)
SAM  A 401 (-4.6A)
None
None
None
1.45A 4pbhA-4rfqA:
undetectable
4pbhA-4rfqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 8 PHE A 309
TYR A 287
PHE A 273
GLY A 195
None
None
None
SAM  A 401 (-3.0A)
0.93A 4qoiA-4rfqA:
undetectable
4qoiB-4rfqA:
undetectable
4qoiA-4rfqA:
20.57
4qoiB-4rfqA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
12 / 12 PRO A  78
GLU A  89
PRO A  90
ILE A 168
TRP A 169
GLN A 216
TYR A 218
GLU A 269
TRP A 270
THR A 295
TYR A 297
TYR A 301
SAM  A 401 (-4.4A)
SAM  A 401 (-3.3A)
SAM  A 401 (-4.4A)
SAM  A 401 (-4.6A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.5A)
None
SAM  A 401 (-4.0A)
SAM  A 401 (-3.2A)
SAM  A 401 (-4.6A)
None
SAM  A 401 (-3.5A)
0.00A 4rfqA-4rfqA:
49.6
4rfqA-4rfqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 4 THR A 172
GLY A 195
ASP A 217
SER A 293
SAM  A 401 (-3.7A)
SAM  A 401 (-3.0A)
SAM  A 401 (-3.0A)
SAM  A 401 (-2.8A)
0.00A 4rfqA-4rfqA:
49.6
4rfqA-4rfqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 GLY A 195
GLY A 197
SER A 198
GLY A 199
GLU A 269
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
None
None
SAM  A 401 (-4.0A)
0.97A 5c0oH-4rfqA:
13.7
5c0oH-4rfqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 GLY A 195
GLY A 197
SER A 198
GLY A 199
LEU A 201
SAM  A 401 (-3.0A)
SAM  A 401 (-4.2A)
None
None
None
0.73A 5c0oH-4rfqA:
13.7
5c0oH-4rfqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 5 PHE A 215
GLY A 199
ILE A 213
LEU A 201
None
0.82A 5dzkB-4rfqA:
undetectable
5dzkI-4rfqA:
undetectable
5dzkW-4rfqA:
undetectable
5dzkB-4rfqA:
21.36
5dzkI-4rfqA:
21.11
5dzkW-4rfqA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 5 PHE A 215
GLY A 199
ILE A 213
LEU A 201
None
0.88A 5dzkd-4rfqA:
undetectable
5dzkk-4rfqA:
undetectable
5dzky-4rfqA:
undetectable
5dzkd-4rfqA:
21.36
5dzkk-4rfqA:
21.11
5dzky-4rfqA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 LEU A 321
THR A 295
LEU A 201
GLY A 195
PHE A 309
None
SAM  A 401 (-4.6A)
None
SAM  A 401 (-3.0A)
None
1.38A 6aphA-4rfqA:
4.7
6aphA-4rfqA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 5 GLU A 212
HIS A 214
LEU A 278
VAL A 277
None
0.90A 6bc9A-4rfqA:
undetectable
6bc9A-4rfqA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
4 / 7 ILE A 290
VAL A 191
ALA A 205
THR A 204
None
0.90A 6cduC-4rfqA:
undetectable
6cduD-4rfqA:
undetectable
6cduC-4rfqA:
20.24
6cduD-4rfqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
3 / 3 LYS A 167
SER A  85
SER A  83
UNX  A 405 ( 3.6A)
None
None
1.04A 6gbfA-4rfqA:
2.0
6gbfA-4rfqA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo
sapiens)
5 / 12 LEU A 321
THR A 295
LEU A 201
GLY A 195
PHE A 309
None
SAM  A 401 (-4.6A)
None
SAM  A 401 (-3.0A)
None
1.44A 6gbnB-4rfqA:
2.0
6gbnB-4rfqA:
21.33