SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		4 / 4 THR S 130
LEU S 134
LEU S 141
GLN S 144
 None
 1.05A 1fbmA-4rfsS:
undetectable		 1fbmA-4rfsS:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		4 / 4 THR S 132
LEU S 136
VAL S 139
LEU S 164
 None
 0.87A 1fbmD-4rfsS:
undetectable		 1fbmD-4rfsS:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 12 VAL S  45
GLY S  42
GLY S  61
SER S  91
VAL S 135
 None
 1.09A 1fduA-4rfsS:
undetectable		 1fduA-4rfsS:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 9 GLY S  65
PHE S  69
LEU S  66
SER S  91
GLY S  62
 None
 1.28A 1jhoA-4rfsS:
undetectable		 1jhoA-4rfsS:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 9 GLY S  65
PHE S  69
LEU S  66
SER S  91
GLY S  62
 None
 1.31A 1jhrA-4rfsS:
undetectable		 1jhrA-4rfsS:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 9 GLY S  65
PHE S  69
LEU S  66
SER S  91
GLY S  62
 None
 1.29A 1l4nA-4rfsS:
undetectable		 1l4nA-4rfsS:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 9 GLY S  65
PHE S  69
LEU S  66
SER S  91
GLY S  62
 None
 1.25A 1l5kA-4rfsS:
undetectable		 1l5kA-4rfsS:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 9 GLY S  65
PHE S  69
LEU S  66
SER S  91
GLY S  62
 None
 1.30A 1l5lA-4rfsS:
undetectable		 1l5lA-4rfsS:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 9 GLY S  65
PHE S  69
LEU S  66
SER S  91
GLY S  62
 None
 1.29A 1l5mA-4rfsS:
undetectable		 1l5mA-4rfsS:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 6 GLY S  53
GLY S  49
GLY S  57
GLY S 103
GLY S  99
 None
 0.86A 3bogB-4rfsS:
undetectable
3bogD-4rfsS:
undetectable		 3bogB-4rfsS:
undetectable
3bogD-4rfsS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 12 LEU S 190
GLY S 103
ALA S 102
GLY S  61
ILE S  60
 None
 1.19A 3gguA-4rfsS:
undetectable		 3gguA-4rfsS:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		4 / 7 TYR S 106
GLU S 195
TRP S 194
LEU S 107
 None
 1.41A 3k8mA-4rfsS:
undetectable		 3k8mA-4rfsS:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		4 / 5 GLY S  49
ALA S  48
GLY S  53
PRO S  54
 None
 0.95A 4u9uA-4rfsS:
undetectable		 4u9uA-4rfsS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		4 / 5 GLY S 103
ALA S 102
GLY S  53
PRO S  54
 None
 0.96A 4u9uA-4rfsS:
undetectable		 4u9uA-4rfsS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		4 / 5 GLY S 103
ALA S 102
GLY S  53
PRO S  54
 None
 0.98A 4u9uB-4rfsS:
undetectable		 4u9uB-4rfsS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 12 LEU S 129
ALA S 128
LEU S 178
LEU S 134
GLY S  61
 None
 1.09A 4xi3C-4rfsS:
undetectable		 4xi3C-4rfsS:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4rfs SUBSTRATE BINDING
PRITEIN S
(Lactobacillus
brevis) 		5 / 12 GLY S  99
GLY S 103
ALA S 123
ALA S 128
LEU S  58
 None
 0.99A 5bw4B-4rfsS:
undetectable		 5bw4B-4rfsS:
23.88