SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4rfv BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 499
ARG A 502
ARG A 503
LEU A 490
 None
 0.78A 1cmaA-4rfvA:
undetectable
1cmaB-4rfvA:
undetectable		 1cmaA-4rfvA:
21.43
1cmaB-4rfvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 4rfv BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		5 / 12 THR A 509
LEU A 511
ALA A 508
TRP A 447
LEU A 482
 None
 1.09A 4xi3C-4rfvA:
undetectable		 4xi3C-4rfvA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4rfv BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 504
ILE A 523
SER A 524
ASP A 480
ASP A 478
 None
 1.28A 6n91A-4rfvA:
2.4		 6n91A-4rfvA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4rfv BIFUNCTIONAL ENZYME
CYSN/CYSC
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 504
ILE A 523
SER A 524
ASP A 480
ASP A 478
 None
 1.26A 6n91B-4rfvA:
2.3		 6n91B-4rfvA:
17.30