SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rg1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 11 LEU A 142
VAL A 114
ILE A 112
LEU A 172
LEU A 149
 None
 1.14A 1mrqA-4rg1A:
undetectable		 1mrqA-4rg1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 11 THR A 289
GLU A 291
GLY A 312
GLY A 316
ALA A 356
 SAH  A 401 (-3.8A)
UNX  A 405 (-4.1A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
 0.34A 1x7pA-4rg1A:
11.1
1x7pB-4rg1A:
11.3		 1x7pA-4rg1A:
24.70
1x7pB-4rg1A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 10 THR A 289
GLU A 291
GLY A 312
GLY A 316
ALA A 356
 SAH  A 401 (-3.8A)
UNX  A 405 (-4.1A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
 0.96A 1x7pA-4rg1A:
11.3
1x7pB-4rg1A:
11.1		 1x7pA-4rg1A:
24.70
1x7pB-4rg1A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4rg1 C9ORF114
(Homo
sapiens) 		4 / 5 PRO A 152
GLY A 192
ASN A 208
GLY A 210
 None
 1.18A 1zlqA-4rg1A:
undetectable		 1zlqA-4rg1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4rg1 C9ORF114
(Homo
sapiens) 		4 / 8 ARG A 265
PHE A 115
LEU A 317
LEU A 308
 None
 1.02A 2bfpA-4rg1A:
undetectable		 2bfpA-4rg1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 GLY A 312
GLY A 316
THR A 350
THR A 353
ALA A 356
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.4A)
 0.79A 2egvA-4rg1A:
13.2		 2egvA-4rg1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 GLY A 312
GLY A 316
THR A 350
THR A 353
ALA A 356
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.4A)
 0.83A 2egvB-4rg1A:
13.0		 2egvB-4rg1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 GLY A 320
GLY A 313
GLY A 316
THR A 353
ILE A 357
 None
SAH  A 401 (-4.5A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.3A)
None
 0.80A 2oxtB-4rg1A:
undetectable		 2oxtB-4rg1A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 10 VAL A  77
ILE A 112
LEU A  96
LEU A 146
GLY A  98
 None
 1.28A 2xf3A-4rg1A:
undetectable		 2xf3A-4rg1A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 LEU A 327
TYR A 339
GLY A 288
THR A 289
SER A 290
 None
None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.6A)
 0.96A 3okxA-4rg1A:
undetectable		 3okxA-4rg1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 LEU A 327
TYR A 339
GLY A 288
THR A 289
SER A 290
 None
None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.6A)
 0.95A 3okxB-4rg1A:
undetectable		 3okxB-4rg1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 ILE A 100
PHE A 311
ALA A 356
THR A 342
ALA A 362
 None
SAH  A 401 (-4.9A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
None
 1.06A 3ua1A-4rg1A:
undetectable		 3ua1A-4rg1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 LEU A 361
ILE A 112
VAL A  77
ILE A  83
LEU A  84
 None
 1.17A 3w67D-4rg1A:
undetectable		 3w67D-4rg1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4rg1 C9ORF114
(Homo
sapiens) 		4 / 7 GLY A 202
ASP A 218
GLY A 204
HIS A 243
 None
 0.91A 4c5nA-4rg1A:
2.0		 4c5nA-4rg1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 10 ALA A 321
LEU A 270
PHE A 115
VAL A 273
THR A 289
 UNX  A 404 ( 3.9A)
None
None
None
SAH  A 401 (-3.8A)
 0.96A 4j14A-4rg1A:
undetectable		 4j14A-4rg1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4rg1 C9ORF114
(Homo
sapiens) 		3 / 3 SER A 177
TYR A 259
PRO A 152
 None
 0.98A 4k8cA-4rg1A:
3.0		 4k8cA-4rg1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4rg1 C9ORF114
(Homo
sapiens) 		3 / 3 SER A 177
TYR A 259
PRO A 152
 None
 0.94A 4kahA-4rg1A:
3.0		 4kahA-4rg1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4rg1 C9ORF114
(Homo
sapiens) 		3 / 3 SER A 177
TYR A 259
PRO A 152
 None
 0.94A 4kahB-4rg1A:
3.0		 4kahB-4rg1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4rg1 C9ORF114
(Homo
sapiens) 		3 / 3 SER A 177
TYR A 259
PRO A 152
 None
 0.98A 4kanB-4rg1A:
3.0		 4kanB-4rg1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4rg1 C9ORF114
(Homo
sapiens) 		3 / 3 SER A 177
TYR A 259
PRO A 152
 None
 0.93A 4kbeA-4rg1A:
2.8		 4kbeA-4rg1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4rg1 C9ORF114
(Homo
sapiens) 		3 / 3 SER A 177
TYR A 259
PRO A 152
 None
 0.91A 4kbeB-4rg1A:
3.1		 4kbeB-4rg1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 LEU A 142
VAL A 114
ILE A 112
LEU A 172
LEU A 149
 None
 1.19A 4yvpB-4rg1A:
undetectable		 4yvpB-4rg1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 12 THR A 289
GLY A 312
GLY A 316
GLN A 346
ALA A 356
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.4A)
 0.63A 5l0zA-4rg1A:
11.7		 5l0zA-4rg1A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 10 THR A 289
GLY A 312
GLY A 316
GLN A 346
ALA A 356
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.8A)
SAH  A 401 (-3.4A)
 0.80A 5l0zB-4rg1A:
4.5		 5l0zB-4rg1A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4rg1 C9ORF114
(Homo
sapiens) 		6 / 11 GLY A 312
GLY A 316
ARG A 352
THR A 353
GLU A 354
ALA A 356
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
None
SAH  A 401 (-4.3A)
None
SAH  A 401 (-3.4A)
 0.82A 5o96G-4rg1A:
11.8		 5o96G-4rg1A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4rg1 C9ORF114
(Homo
sapiens) 		5 / 9 ALA A 323
GLY A 320
ALA A 272
SER A 271
SER A 268
 None
 1.04A 6bklE-4rg1A:
undetectable
6bklF-4rg1A:
undetectable
6bklG-4rg1A:
undetectable
6bklH-4rg1A:
undetectable		 6bklE-4rg1A:
5.63
6bklF-4rg1A:
5.63
6bklG-4rg1A:
5.63
6bklH-4rg1A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4rg1 C9ORF114
(Homo
sapiens) 		4 / 7 ARG A 265
TYR A 283
LEU A  75
VAL A 109
 None
 1.19A 6g2pA-4rg1A:
2.0		 6g2pA-4rg1A:
21.33