SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 8 PHE A 516
LEU A 612
THR A 611
HIS A 615
 None
 0.96A 1azmA-4rg6A:
undetectable		 1azmA-4rg6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 8 PHE A 516
LEU A 612
THR A 611
HIS A 615
 None
 0.93A 1bzmA-4rg6A:
undetectable		 1bzmA-4rg6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 7 PHE A 720
SER A 675
ALA A 716
PHE A 713
 None
 1.09A 1fxvA-4rg6A:
undetectable
1fxvB-4rg6A:
undetectable		 1fxvA-4rg6A:
16.42
1fxvB-4rg6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 4 TYR A  32
LEU A  43
LEU A  44
HIS A  64
 None
 1.23A 2x7hB-4rg6A:
undetectable		 2x7hB-4rg6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 4 TYR A 645
LEU A 677
LEU A 678
HIS A 714
 None
 1.44A 2x7hB-4rg6A:
undetectable		 2x7hB-4rg6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		5 / 12 TRP A 149
ARG A 473
THR A 167
SER A 150
ILE A 158
 None
 1.33A 3iv6C-4rg6A:
undetectable		 3iv6C-4rg6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 5 ILE A 544
THR A 547
HIS A 640
TYR A 485
 None
 1.09A 4oltB-4rg6A:
undetectable		 4oltB-4rg6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 6 ILE A 544
THR A 547
HIS A 640
TYR A 485
 None
 1.06A 4qwpA-4rg6A:
undetectable		 4qwpA-4rg6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_ACTA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		4 / 4 ALA A 557
LYS A 554
TYR A 545
GLU A 525
 None
 1.41A 4rvdA-4rg6A:
0.0		 4rvdA-4rg6A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A  41
ILE A  12
ASP A  23
LEU A  60
ALA A  45
 None
 1.17A 5h5fA-4rg6A:
undetectable		 5h5fA-4rg6A:
19.15