SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		5 / 9 LEU A 267
LEU A 270
LEU A 279
ARG A 278
ILE A 293
 None
 1.16A 2f7aA-4rg8A:
undetectable		 2f7aA-4rg8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		5 / 12 ARG A 114
ARG A 109
GLU A 123
ARG A 122
TYR A  10
 None
 1.38A 2htuA-4rg8A:
undetectable		 2htuA-4rg8A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		3 / 3 ASN A 253
ASN A 301
ARG A 109
 None
 0.76A 2rlcA-4rg8A:
undetectable		 2rlcA-4rg8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		5 / 9 GLY A  97
ASP A 104
GLY A  29
ILE A  30
THR A  93
 None
MG  A 501 ( 4.1A)
None
None
None
 1.05A 3gguB-4rg8A:
undetectable		 3gguB-4rg8A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		5 / 10 GLY A  97
ASP A 104
ILE A  84
GLY A  29
ILE A  30
 None
MG  A 501 ( 4.1A)
None
None
None
 0.93A 3lzvA-4rg8A:
undetectable		 3lzvA-4rg8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 5 LEU A 226
LEU A 309
LEU A 260
SER A 261
 None
 0.91A 3vhuA-4rg8A:
undetectable		 3vhuA-4rg8A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 5 THR A  82
PHE A 412
ASN A 115
TYR A 407
 None
 1.19A 4mf6A-4rg8A:
undetectable		 4mf6A-4rg8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		6 / 11 GLY A  97
ASP A 104
ILE A  84
GLY A  29
ILE A  30
THR A  93
 None
MG  A 501 ( 4.1A)
None
None
None
None
 1.14A 4njvC-4rg8A:
undetectable		 4njvC-4rg8A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		3 / 3 LEU A 137
ARG A 138
ARG A 141
 None
 0.86A 4yiaB-4rg8A:
undetectable		 4yiaB-4rg8A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 5 LEU A 312
ALA A 307
LEU A 309
VAL A 305
 None
 1.09A 5cr1A-4rg8A:
undetectable		 5cr1A-4rg8A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 4 ASP A 397
GLY A 367
ASP A 366
ASP A 358
 None
 1.18A 5e72A-4rg8A:
undetectable		 5e72A-4rg8A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 7 GLY A  97
ASP A 104
GLY A  29
ILE A  30
 None
MG  A 501 ( 4.1A)
None
None
 0.62A 5kqyB-4rg8A:
undetectable		 5kqyB-4rg8A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 7 ASP A 104
GLY A  97
ASP A  11
ASN A  99
 MG  A 501 ( 4.1A)
None
MG  A 501 (-2.4A)
None
 1.07A 5nnwD-4rg8A:
undetectable		 5nnwD-4rg8A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 7 ASP A 104
GLY A  97
ASP A  11
ASN A  99
 MG  A 501 ( 4.1A)
None
MG  A 501 (-2.4A)
None
 1.08A 5no9D-4rg8A:
undetectable		 5no9D-4rg8A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 6 ALA A 164
LEU A 162
TYR A  98
SER A 159
 None
 1.01A 5phhA-4rg8A:
undetectable		 5phhA-4rg8A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 7 LEU A 334
PRO A 264
LEU A 245
TYR A 258
 None
 1.07A 5t7bA-4rg8A:
undetectable		 5t7bA-4rg8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 8 THR A  82
ASN A 411
TYR A 407
PHE A 412
 None
 1.04A 5v4vA-4rg8A:
undetectable		 5v4vA-4rg8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 8 THR A  82
ASN A 411
TYR A 407
PHE A 412
 None
 1.03A 5v4vB-4rg8A:
undetectable		 5v4vB-4rg8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		5 / 9 VAL A 290
GLY A 289
ILE A 268
LEU A 267
ASP A 274
 None
 1.40A 6c2mC-4rg8A:
undetectable		 6c2mC-4rg8A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4rg8 EXONUCLEASE I
(Methylocaldum
szegediense) 		4 / 7 HIS A  85
ARG A 374
GLU A 121
ASP A 118
 None
 1.31A 6mn4E-4rg8A:
undetectable		 6mn4E-4rg8A:
20.78