SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ILE A 334
LEU A 245
PHE A 342
LEU A 344
ILE A 255
 None
 0.96A 1drbB-4rggA:
undetectable		 1drbB-4rggA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 GLY A  53
MET A 148
LEU A 150
ILE A  64
LEU A 118
 None
 1.03A 1lhuA-4rggA:
undetectable		 1lhuA-4rggA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ILE A 334
LEU A 245
PHE A 342
LEU A 344
ILE A 255
 None
 1.03A 1rb2B-4rggA:
undetectable		 1rb2B-4rggA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		3 / 3 GLN A 166
ILE A 167
TYR A 151
 None
 0.71A 1vifA-4rggA:
undetectable		 1vifA-4rggA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 9 LEU A 376
ILE A 255
PHE A 342
LEU A 344
ILE A 205
 None
 1.13A 2f7aA-4rggA:
undetectable		 2f7aA-4rggA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		3 / 3 TYR A 281
GLY A 349
PHE A 282
 None
 0.67A 2m2pB-4rggA:
undetectable		 2m2pB-4rggA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ALA A 321
THR A 348
PHE A 346
ILE A 261
PHE A 282
 None
 1.28A 2v95A-4rggA:
undetectable		 2v95A-4rggA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 10 ALA A 300
LEU A 126
VAL A 123
SER A 169
ILE A 167
 None
 1.05A 2w9hA-4rggA:
undetectable		 2w9hA-4rggA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 7 ILE A 167
LEU A 150
VAL A  32
GLY A  31
ARG A 132
 None
 0.98A 2wd9A-4rggA:
undetectable		 2wd9A-4rggA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 8 ILE A 167
LEU A 150
VAL A  32
GLY A  31
ARG A 132
 None
 0.97A 2wd9B-4rggA:
undetectable		 2wd9B-4rggA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 10 ILE A 167
LEU A 150
VAL A  32
GLY A  31
ARG A 132
 None
 1.00A 2wd9C-4rggA:
undetectable		 2wd9C-4rggA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ILE A 146
GLY A  59
LEU A 136
ALA A  25
VAL A  56
 None
 1.10A 2yvlA-4rggA:
undetectable		 2yvlA-4rggA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ILE A 146
GLY A  59
LEU A 136
ALA A  25
VAL A  56
 None
 1.09A 2yvlB-4rggA:
undetectable		 2yvlB-4rggA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ILE A 146
GLY A  59
LEU A 136
ALA A  25
VAL A  56
 None
 1.03A 2yvlD-4rggA:
undetectable		 2yvlD-4rggA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ILE A 252
ARG A 378
ASP A 340
SER A 290
ALA A 296
 None
 1.19A 3axtA-4rggA:
undetectable		 3axtA-4rggA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 4 SER A  30
GLY A  31
GLY A  59
GLY A  61
 None
 0.93A 3bogB-4rggA:
undetectable
3bogD-4rggA:
undetectable		 3bogB-4rggA:
undetectable
3bogD-4rggA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		3 / 3 ASN A 206
ASP A 235
ARG A 132
 None
 0.93A 3k13A-4rggA:
undetectable		 3k13A-4rggA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ARG A  29
ILE A  92
GLY A  31
GLY A  59
LEU A  22
 None
 1.10A 4e1gB-4rggA:
undetectable		 4e1gB-4rggA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 CYH A 188
TYR A 223
ASN A 371
LEU A 369
ILE A 203
 None
 1.48A 4k36B-4rggA:
undetectable		 4k36B-4rggA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 8 PHE A 240
ASP A 235
ALA A 292
SER A 291
 GN1  A 401 ( 4.3A)
None
GN1  A 401 (-3.6A)
GN1  A 401 (-3.0A)
 1.15A 4lv9A-4rggA:
undetectable
4lv9B-4rggA:
undetectable		 4lv9A-4rggA:
23.09
4lv9B-4rggA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 7 PHE A 240
ASP A 235
ALA A 292
SER A 291
 GN1  A 401 ( 4.3A)
None
GN1  A 401 (-3.6A)
GN1  A 401 (-3.0A)
 1.16A 4lv9A-4rggA:
undetectable
4lv9B-4rggA:
undetectable		 4lv9A-4rggA:
23.09
4lv9B-4rggA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		3 / 3 ARG A 370
HIS A 368
SER A 260
 None
 0.94A 4mjwA-4rggA:
undetectable
4mjwB-4rggA:
undetectable		 4mjwA-4rggA:
22.16
4mjwB-4rggA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		3 / 3 SER A 260
ARG A 370
HIS A 368
 None
 0.93A 4mjwA-4rggA:
undetectable
4mjwB-4rggA:
undetectable		 4mjwA-4rggA:
22.16
4mjwB-4rggA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 6 ILE A  62
THR A  54
VAL A  32
HIS A  52
 None
 0.85A 5eclD-4rggA:
undetectable		 5eclD-4rggA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		5 / 12 ILE A 247
GLU A 249
GLY A 251
ARG A 378
CYH A 286
 None
 1.45A 5fhzD-4rggA:
undetectable		 5fhzD-4rggA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 4 VAL A 246
GLU A 248
GLY A 339
LEU A 295
 None
 1.08A 5g5gC-4rggA:
undetectable		 5g5gC-4rggA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 7 SER A 202
ASP A 243
PRO A 242
PHE A 240
 None
None
None
GN1  A 401 ( 4.3A)
 1.26A 5l1fC-4rggA:
undetectable		 5l1fC-4rggA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		3 / 3 GLN A  27
TYR A 182
ASN A 179
 None
 0.91A 6dwdC-4rggA:
undetectable		 6dwdC-4rggA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4rgg PUTATIVE PHAGE
STRUCTURAL PROTEIN
(Lactococcus
phage
1358) 		4 / 6 ASP A 133
ASN A 170
LEU A  57
SER A  30
 None
 1.27A 6ekuA-4rggA:
undetectable		 6ekuA-4rggA:
20.93