SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4rgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
GLY A 252
PRO A 285
 None
 0.82A 1c6yB-4rghA:
11.1		 1c6yB-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
VAL A 253
PRO A 285
 None
 0.52A 1fb7A-4rghA:
10.6		 1fb7A-4rghA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.55A 1hshC-4rghA:
11.0		 1hshC-4rghA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.77A 1sguB-4rghA:
10.2		 1sguB-4rghA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.61A 1sguB-4rghA:
10.2		 1sguB-4rghA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.55A 2b60A-4rghA:
10.5		 2b60A-4rghA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 11 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.63A 2b60B-4rghA:
10.5		 2b60B-4rghA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.84A 2hs1A-4rghA:
10.1		 2hs1A-4rghA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.52A 2hs1B-4rghA:
10.4		 2hs1B-4rghA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.85A 2rkfA-4rghA:
10.6		 2rkfA-4rghA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.61A 2rkfA-4rghA:
10.6		 2rkfA-4rghA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.83A 2rkgB-4rghA:
11.2		 2rkgB-4rghA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.57A 2rkgB-4rghA:
11.2		 2rkgB-4rghA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 11 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.90A 3ebzB-4rghA:
10.9		 3ebzB-4rghA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
VAL A 253
PRO A 285
 None
 0.85A 3ekqA-4rghA:
10.5		 3ekqA-4rghA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		4 / 8 ASP A 220
GLY A 222
ALA A 223
PRO A 285
 None
 0.58A 3el0A-4rghA:
10.4		 3el0A-4rghA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 9 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.84A 3nu4B-4rghA:
10.5		 3nu4B-4rghA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 9 ASP A 220
GLY A 222
ALA A 223
GLY A 252
LEU A 289
 None
 0.94A 3ogpA-4rghA:
11.0		 3ogpA-4rghA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 9 ASP A 220
GLY A 222
ALA A 223
GLY A 252
LEU A 289
 None
 1.04A 3ogpB-4rghA:
11.0		 3ogpB-4rghA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 10 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.86A 3s43B-4rghA:
10.5		 3s43B-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 11 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.87A 3s45B-4rghA:
10.9		 3s45B-4rghA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 9 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.82A 3s53A-4rghA:
10.4		 3s53A-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.79A 3s56A-4rghA:
10.2		 3s56A-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.52A 3s56A-4rghA:
10.2		 3s56A-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.90A 3ucbA-4rghA:
10.3		 3ucbA-4rghA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 11 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.78A 4q1xA-4rghA:
10.8		 4q1xA-4rghA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 10 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.77A 4q1yA-4rghA:
10.8		 4q1yA-4rghA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.84A 5e5jA-4rghA:
10.6		 5e5jA-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.88A 5e5kB-4rghA:
10.5		 5e5kB-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
PRO A 285
 None
 0.55A 5e5kB-4rghA:
10.5		 5e5kB-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		5 / 12 ASP A 220
GLY A 222
ALA A 223
ILE A 227
GLY A 252
 None
 0.82A 5t8hA-4rghA:
10.6		 5t8hA-4rghA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		4 / 5 ILE A 206
GLN A 317
THR A 318
LEU A 304
 None
 1.03A 6f3mD-4rghA:
undetectable		 6f3mD-4rghA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4rgh PROTEIN DDI1 HOMOLOG
2
(Homo
sapiens) 		3 / 3 ARG A 297
PHE A 273
PHE A 278
 None
 1.03A 6nknC-4rghA:
undetectable
6nknJ-4rghA:
undetectable		 6nknC-4rghA:
19.01
6nknJ-4rghA:
14.79